Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Vi T, Tang"'
Autor:
Vi T. Tang, David Ginsburg
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Most proteins destined for the extracellular space or various intracellular compartments must traverse the intracellular secretory pathway. The first step is the recruitment and transport of cargoes from the endoplasmic reticulum (ER) lumen to the Go
Externí odkaz:
https://doaj.org/article/ee1bd5cbd9e740bca717094050de240e
Autor:
Elizabeth J. Adams, Rami Khoriaty, Anna Kiseleva, Audrey C. A. Cleuren, Kärt Tomberg, Martijn A. van der Ent, Peter Gergics, Vi T. Tang, Guojing Zhu, Mark J. Hoenerhoff, K. Sue O’Shea, Thomas L. Saunders, David Ginsburg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The COPII component SEC24 mediates the recruitment of transmembrane cargos or cargo adaptors into newly forming COPII vesicles on the ER membrane. Mammalian genomes encode four Sec24 paralogs (Sec24a-d), with two subfamilies based on sequenc
Externí odkaz:
https://doaj.org/article/4bcbdf66d6ff48cf95ab2150fccf4a2b
Autor:
Vi T Tang, Joseph McCormick, Bolin Xu, Yawei Wang, Huan Fang, Xiao Wang, David Siemieniak, Rami Khoriaty, Brian T Emmer, Xiao-Wei Chen, David Ginsburg
Publikováno v:
eLife, Vol 11 (2022)
PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor t
Externí odkaz:
https://doaj.org/article/a6d70a225b594945be13e85a8f5d5bed
Autor:
Emily J Sherman, Carmen Mirabelli, Vi T Tang, Taslima G Khan, Kyle Leix, Andrew A Kennedy, Sarah E Graham, Cristen J Willer, Andrew W Tai, Jonathan Z Sexton, Christiane E Wobus, Brian T Emmer
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010377 (2022)
SARS-CoV-2 infection is initiated by binding of the viral spike protein to its receptor, ACE2, on the surface of host cells. ACE2 expression is heterogeneous both in vivo and in immortalized cell lines, but the molecular pathways that govern ACE2 exp
Externí odkaz:
https://doaj.org/article/acccdef33b934d528edc14fc2c53eec4
Autor:
Vi T. Tang, Jie Xiang, Zhimin Chen, McCormick, Joseph, Abbineni, Prabhodh S., Xiao-Wei Chen, Hoenerhoff, Mark, Emmer, Brian T., Khoriaty, Rami, Jiandie D. Lin, Ginsburg, David
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 5/7/2024, Vol. 121 Issue 19, p1-9, 15p
Autor:
Brian T Emmer, Paul J Lascuna, Vi T Tang, Emilee N Kotnik, Thomas L Saunders, Rami Khoriaty, David Ginsburg
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227450 (2020)
Newly synthesized proteins co-translationally inserted into the endoplasmic reticulum (ER) lumen may be recruited into anterograde transport vesicles by their association with specific cargo receptors. We recently identified a role for the cargo rece
Externí odkaz:
https://doaj.org/article/727d58a836d841bb96970c37a76b1129
Autor:
Brian T Emmer, Geoffrey G Hesketh, Emilee Kotnik, Vi T Tang, Paul J Lascuna, Jie Xiang, Anne-Claude Gingras, Xiao-Wei Chen, David Ginsburg
Publikováno v:
eLife, Vol 7 (2018)
PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory pathway, but its identity has remained elusive.
Externí odkaz:
https://doaj.org/article/4d0ae922f1f64db9a2cd6c2f5d6ed374
Autor:
Vi T Tang, Joseph McCormick, Bolin Xu, Yawei Wang, Huan Fang, Xiao Wang, David Siemieniak, Rami Khoriaty, Brian T Emmer, Xiao-Wei Chen, David Ginsburg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3503f89a118f5c2b1197f9a8510dc8c3
https://doi.org/10.7554/elife.82269.sa2
https://doi.org/10.7554/elife.82269.sa2
Autor:
Vi T. Tang, Joseph McCormick, Bolin Xu, Yawei Wang, Huan Fang, Xiao Wang, David Siemieniak, Rami Khoriaty, Brian T. Emmer, Xiao-Wei Chen, David Ginsburg
PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282aa8f739013dddc032c896762afd16
https://doi.org/10.1101/2022.08.01.502222
https://doi.org/10.1101/2022.08.01.502222
Autor:
Vi T. Tang, Kathryn Ufford, Zhaowen Tong, Allen P. Liu, Sabrina Friedline, Stephanie L. Bielas, Adam S. Helms, Amani S. Dobbs, Yao-Chang Tsan
Publikováno v:
Stem Cell Reports
Summary Disease modeling and pharmaceutical testing using cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) requires accurate assessment of contractile function. Micropatterning iPSC-CMs on elastic substrates controls cell shape a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154c591212a944f7d88f4f00063d3fdc
https://doi.org/10.1016/j.stemcr.2021.01.007
https://doi.org/10.1016/j.stemcr.2021.01.007