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Sequencing of VDJ genes in Lepus americanus confirms a correlation between VHn expression and the leporid species continent of origin

Autor: Jacob L. Seguin, Dennis K. Lanning, Tereza Almeida, Melanie R. Boudreau, Ana Acacia S. Pinheiro, Patrícia de Sousa-Pereira, Josée-Anne Otis, Catarina Ferreira, Pedro J. Esteves

Publikováno v: Molecular immunology. 112

Leporid VH genes used in the generation of their primary antibody repertoire exhibit highly divergent lineages. For the European rabbit (Oryctolagus cuniculus) four VHa lineages have been described, the a1, a2, a3 and a4. Hares (Lepus spp.) and cotto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d0703a850847c070821bffaeca0b69
https://pubmed.ncbi.nlm.nih.gov/31174011

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VH gene usage and CDR3 analysis of B cell receptor in the peripheral blood of patients with PBC

Autor: Angela L. Foreman, Brigitte Lemercier, Annick Lim, Phillipe Kourlisky, Thomas Kenny, M. Eric Gershwin, Marie-Lise Gougeon

Publikováno v: Autoimmunity. 41:80-86

We have analyzed the IgM, IgG and IgA BCR repertoire in PBC patients by means of quantitative RT-PCR and CDR3-spectratyping with immunoscope technology. PBMC from 35 PBC patients and 18 normal controls were analyzed. Quantitative B cell repertoire an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fec2d050c01c588f0aafb53ce935c4
https://doi.org/10.1080/08916930701619656

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Chronic lymphocytic leukemia patients with a V1-69 gene rearrangement do not have inferior survival with respect to patients that express other unmutated VH genes

Autor: Lidija Cevreska, Irina Panovska-Stavridis, Nikola Siljanovski, Martin Ivanovski, Dimitar G. Efremov

Publikováno v: Leukemia Research. 31:245-248

Recent studies indicate that V(H) gene usage in B-CLL may have prognostic impact independently of V(H) gene mutation status. The V1-69 gene is the most frequently rearranged V(H) gene in B-CLL and is almost always unmutated. We therefore investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5888d10155bb392aa39ca662481f404d
https://doi.org/10.1016/j.leukres.2006.05.008

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Sterile DJH rearrangements reveal that distance between gene segments on the human Ig H chain locus influences their ability to rearrange

Autor: Tina Østergaard Hansen, Torben Barington, Anders Blaabjerg Lange

Publikováno v: Hansen, T Ø, Lange, A B & Barington, T 2015, ' Sterile DJH rearrangements reveal that distance between gene segments on the human Ig H chain locus influences their ability to rearrange ', Journal of Immunology, vol. 194, no. 3, pp. 973-982 . https://doi.org/10.4049/jimmunol.1401443

Rearrangement of the Ig locus occurs in two steps. First, a JH gene is rearranged to a D gene followed by a VH gene rearranging to the DJH rearrangement. By next generation sequencing, we analyzed 9969 unique DJH rearrangements and 5919 unique VHDJH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1c8049892574e93e3e05a994f429e2
https://pubmed.ncbi.nlm.nih.gov/25556246

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Pattern and Distribution of Immunoglobulin VH Gene Usage in a Cohort of B-CLL Patients From a Northeastern Region of Italy

Autor: Nadia Di Lorenzo, Claudia Sarpellon, Giovanni Bertoldero, Vincenzo Stracca-Pansa, Simona Zupo, Alessandro Paparella, Pietro Maria Donisi, Claudia Minotto, Manuela Riccardi

Publikováno v: Diagnostic Molecular Pathology. 15:206-215

We analyzed individual VH gene rearrangements in 55 consecutive B-chronic lymphocytic leukemia (B-CLL) patients collected from a northeastern region of Italy, stressing the possible differences related to geographic characteristics of the cohorts stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba38d907785cb30f6f896689558aeac
https://doi.org/10.1097/01.pdm.0000213469.85301.d6

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VH3-21 Gene Usage in Chronic Lymphocytic Leukemia – Characterization of a New Subgroup with Distinct Molecular Features and Poor Survival

Autor: Gerard Tobin, Ola Söderberg, Richard Rosenquist, Ulf Thunberg

Publikováno v: Leukemia & Lymphoma. 45:221-228

During recent years it has become evident that lymphoproliferative diseases of B-cell origin display preferential immunoglobulin (Ig) variable heavy chain (V(H)) gene usage. For instance, the V(H)1-69 and V(H)4-34 genes were early found to be overexp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64d11aca39ec42c231e4ee119287a16
https://doi.org/10.1080/1042819031000147018

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By-products of immunoglobulin somatic hypermutation

Autor: Michael S. Neuberger, Mats Bemark

Publikováno v: Genes, Chromosomes and Cancer. 38:32-39

The antigen receptor loci are the only loci in humans to undergo programmed somatic gene modification. Although aberrant V(D)J integration and class switch recombination can both give rise to chromosomal translocations, a role for somatic hypermutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6c9387a50de42ac5ddb3a147e14059
https://doi.org/10.1002/gcc.10241

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