Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Vf, Vellucci"'
Autor:
HA Yegen, VF Vellucci, Howard D. Strickler, de Elisabeth G. E. Vries, Michael Reiss, A Hildesheim, Taiping Chen, Harmen Hollema
Publikováno v:
International Journal of Cancer. 82:43-51
The development and progression of invasive uterine cervical carcinomas appear to be associated with the progressive loss of sensitivity to transforming growth factor-beta (TGFbeta)-mediated cell cycle arrest. In order to identify possible molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f468ac0823ee6aaa11290f0ab5a24790
https://doi.org/10.1002/(sici)1097-0215(19990702)82:1<43::aid-ijc9>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19990702)82:1<43::aid-ijc9>3.0.co
Publikováno v:
Europe PubMed Central
In this study, we report the occurrence of missense mutations of the transforming growth factor beta (TGF beta) type II receptor gene in two human squamous head and neck carcinoma cell lines. Both mutations are G:C--C:G transversions, which result in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8ecc8a4f5cf41f761af59e9028dc02d4
https://pubmed.ncbi.nlm.nih.gov/7664267
https://pubmed.ncbi.nlm.nih.gov/7664267
Publikováno v:
Europe PubMed Central
In order to clarify the role of the p53 tumor suppressor gene in controlling growth and differentiation of human epithelial cells, we transfected a wild-type p53 complementary DNA, driven by a dexamethasone-inducible mouse mammary tumor virus promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8dd49a42a50389de46107fb7b3be4f97
https://pubmed.ncbi.nlm.nih.gov/8117626
https://pubmed.ncbi.nlm.nih.gov/8117626
Publikováno v:
Europe PubMed Central
Human carcinoma cell lines are frequently refractory to the antiproliferative effect of the autocrine growth inhibitor transforming growth factor beta 1 (TGF-beta 1) and often express mutant forms of the tumor suppressor gene p53. Therefore, we wishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::150d9bb470f9e2cda7f135cbbde9127f
https://pubmed.ncbi.nlm.nih.gov/8094035
https://pubmed.ncbi.nlm.nih.gov/8094035
Publikováno v:
Europe PubMed Central
Transforming growth factor alpha is an autocrine mitogen for nonneoplastic keratinocytes, which exerts its function by binding to the receptor for epidermal growth factor. In order to determine whether this autocrine pathway is activated in squamous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a633fd4d442811b28760b97dfb00de4a
https://pubmed.ncbi.nlm.nih.gov/1933886
https://pubmed.ncbi.nlm.nih.gov/1933886
Publikováno v:
Europe PubMed Central
Small-cell lung cancer (SCLC) has a significantly worse prognosis than other forms of bronchogenic carcinoma. Because transforming growth factor beta (TGF-beta) appears to play an important role in the pathogenesis of SCLC, we examined the status of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::85de61d7a9e9bf4f4491ba16085d0385
http://europepmc.org/abstract/med/9167190
http://europepmc.org/abstract/med/9167190
Autor:
Rf, Souza, Laure Garrigue-Antar, Lei J, Yin J, Appel R, Vf, Vellucci, Tt, Zou, Zhou X, Wang S, Mg, Rhyu, Cymes K, Chan O, Ws, Park, Mj, Krasna, Bd, Greenwald, Cottrell J, Jm, Abraham, Simms L, Leggett B, Sj, Meltzer
Publikováno v:
Europe PubMed Central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c578bd69d9a8553bec98c5542b21ce5d
http://europepmc.org/abstract/med/9183654
http://europepmc.org/abstract/med/9183654
Publikováno v:
Europe PubMed Central
Cell lines derived from carcinomas of the upper aero-digestive tract are typically refractory to transforming growth factor beta-mediated cell cycle arrest. Recently, we reported that the type II transforming growth factor beta receptor (T beta R-II)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0d2a5c4c65753cabd98469fcf8e5a63e
http://europepmc.org/abstract/med/8765326
http://europepmc.org/abstract/med/8765326
Publikováno v:
Europe PubMed Central
Cytogenetic, allelotype, and somatic cell hybrid studies of human head and neck cancers had suggested that the long arm of chromosome 18 might carry a tumor suppressor gene locus. To directly test this hypothesis, we introduced a wild-type copy of ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::593c8abb1f1926979ac19bc087b29f8f
http://europepmc.org/abstract/med/9101086
http://europepmc.org/abstract/med/9101086
Publikováno v:
Europe PubMed Central
Dominant-negative and/or loss-of-function mutations of the p53 tumor suppressor gene are frequently found in squamous cell carcinomas of the skin and of the head-and-neck region. In order to identify the precise mechanisms of inactivation of p53 in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f588776f3221fbee41342efa470e5e48
http://europepmc.org/abstract/med/1486218
http://europepmc.org/abstract/med/1486218