Metagenomic analysis during capecitabine therapy reveals microbial chemoprotective mechanisms and predicts drug toxicity in colorectal cancer patients.

Autor: Hillege LE; GROW - Research Institute for Oncology and Reproduction, Maastricht University; Maastricht, Netherlands.; Department of Surgery, Maastricht University Medical Center+; Maastricht, Netherlands., Trepka KR; Department of Microbiology and Immunology, University of California San Francisco; San Francisco, USA., Ziemons J; GROW - Research Institute for Oncology and Reproduction, Maastricht University; Maastricht, Netherlands.; Department of Surgery, Maastricht University Medical Center+; Maastricht, Netherlands., Aarnoutse R; GROW - Research Institute for Oncology and Reproduction, Maastricht University; Maastricht, Netherlands.; Department of Surgery, Maastricht University Medical Center+; Maastricht, Netherlands., Guthrie BGH; Department of Microbiology and Immunology, University of California San Francisco; San Francisco, USA., de Vos-Geelen J; GROW - Research Institute for Oncology and Reproduction, Maastricht University; Maastricht, Netherlands.; Department of Internal Medicine, Division of Medical Oncology, Maastricht University Medical Center+; Maastricht, The Netherlands., Valkenburg-van Iersel L; GROW - Research Institute for Oncology and Reproduction, Maastricht University; Maastricht, Netherlands.; Department of Internal Medicine, Division of Medical Oncology, Maastricht University Medical Center+; Maastricht, The Netherlands., van Hellemond IEG; Department of Medical Oncology, Catharina Hospital; Eindhoven, The Netherlands., Baars A; Department of Medical Oncology, Hospital Gelderse Vallei; Ede, The Netherlands., Vestjens JHMJ; Department of Internal Medicine, VieCuri Medical Center; Venlo, The Netherlands., Penders J; NUTRIM - Institute of Nutrition and Translational Research in Metabolism, Maastricht University; Maastricht, The Netherlands.; Department of Medical Microbiology, Infectious Diseases, and Infection Prevention, Maastricht University Medical Center+; Maastricht, The Netherlands., Deutschbauer A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory; Berkeley, USA., Atreya CE; Department of Medicine, Division of Hematology and Oncology, University of California San Francisco; San Francisco, USA.; UCSF Helen Diller Family Comprehensive Cancer Center; San Francisco, USA., Kidder WA; Department of Medicine, Division of Hematology and Oncology, University of California San Francisco; San Francisco, USA.; UCSF Helen Diller Family Comprehensive Cancer Center; San Francisco, USA., Turnbaugh PJ; Department of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.; Chan Zuckerberg Biohub-San Francisco; San Francisco, USA., Smidt ML; GROW - Research Institute for Oncology and Reproduction, Maastricht University; Maastricht, Netherlands.; Department of Surgery, Maastricht University Medical Center+; Maastricht, Netherlands.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.

Relevant impact of central pathology review on nodal classification in individual breast cancer patients.

Autor: Vestjens JHMJ; Department of Internal Medicine, Division of Medical Oncology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht., Pepels MJ; Department of Internal Medicine, Division of Medical Oncology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht., de Boer M; Department of Internal Medicine, Division of Medical Oncology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht., Borm GF; Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre Nijmegen, Nijmegen., van Deurzen CHM; Department of Pathology, University Medical Centre Utrecht, Utrecht., van Diest PJ; Department of Pathology, University Medical Centre Utrecht, Utrecht., van Dijck JAAM; Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre Nijmegen, Nijmegen., Adang EMM; Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre Nijmegen, Nijmegen., Nortier JWR; Department of Internal Medicine, Division of Medical Oncology, Leiden University Medical Centre, Leiden., Rutgers EJT; Department of Surgery, The Netherlands Cancer Institute, Amsterdam., Seynaeve C; Department of Internal Medicine, Division of Medical Oncology., Menke-Pluymers MBE; Department of Surgery, Erasmus Medical Centre-Daniel den Hoed Cancer Centre, Rotterdam., Bult P; Department of Pathology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands., Tjan-Heijnen VCG; Department of Internal Medicine, Division of Medical Oncology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht. Electronic address: vcg.tjan.heijnen@mumc.nl.

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2012 Oct; Vol. 23 (10), pp. 2561-2566. Date of Electronic Publication: 2012 Apr 11.