Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Vesna Jevtovic-Todorovic"'
Autor:
Thy B Nguyen, Nathaen Weitzel, Craig Hogan, Rachel M Kacmar, Kayla M Williamson, Jack Pattee, Vesna Jevtovic-Todorovic, Colby G Simmons, Adeel Ahmad Faruki
Publikováno v:
JMIR Perioperative Medicine, Vol 7, p e45126 (2024)
BackgroundOsteoarthritis is a significant cause of disability, resulting in increased joint replacement surgeries and health care costs. Establishing benchmarks that more accurately predict surgical duration could help to decrease costs, maximize eff
Externí odkaz:
https://doaj.org/article/9754566c2b264d4097f2258021d5701e
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1654 (2023)
Published evidence over the past few decades suggests that general anesthetics could be neurotoxins especially when administered at the extremes of age. The reported pathology is not only at the morphological level when examined in very young and age
Externí odkaz:
https://doaj.org/article/70f434b9e298463997b05aa5b8430e44
Autor:
Omar Hoseá Cabrera, Nemanja Useinovic, Stefan Maksimovic, Michelle Near, Nidia Quillinan, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic
Publikováno v:
Neurobiology of Disease, Vol 175, Iss , Pp 105923- (2022)
Preclinical models demonstrate that nearly all anesthetics cause widespread neuroapoptosis in the developing brains of infant rodents and non-human primates. Anesthesia-induced developmental apoptosis is succeeded by prolonged neuropathology in the s
Externí odkaz:
https://doaj.org/article/69fe6a65dbdd4959a6b3aa0287f446f5
Autor:
Tamara Timic Stamenic, Francesca M. Manzella, Stefan Maksimovic, Kathiresan Krishnan, Douglas F. Covey, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
We recently reported that a neurosteroid analogue with T-channel-blocking properties (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis in rat pups without triggering neuronal apoptosis. Furthermore, we found that the inhib
Externí odkaz:
https://doaj.org/article/81ceb9b8553949458fa215c3060c28cb
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Treating pain in patients suffering from small fiber neuropathies still represents a therapeutic challenge for health care providers and drug developers worldwide. Unfortunately, none of the currently available treatments can completely reverse sympt
Externí odkaz:
https://doaj.org/article/45116cfad83948b78fe8091c2f438936
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Cancer remains the leading cause of death worldwide with close to 10 million deaths reported annually. Due to growth of the advanced age cohort in our population, it is predicted that the number of new cancer cases diagnosed between now until 2035 is
Externí odkaz:
https://doaj.org/article/c2354e9acbef4fc1be8ece2bf968e618
Autor:
Francesca M. Manzella, Bethany F. Gulvezan, Stefan Maksimovic, Nemanja Useinovic, Yogendra H. Raol, Srdjan M. Joksimovic, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
General anesthetics are neurotoxic to the developing rodent and primate brains leading to neurocognitive and socio-affective impairment later in life. In addition, sleep patterns are important predictors of cognitive outcomes. Yet, little is known ab
Externí odkaz:
https://doaj.org/article/7257d81640974cecabbfea2144a4d7a5
Autor:
Donald H. Penning, Simona Cazacu, Aharon Brodie, Vesna Jevtovic-Todorovic, Steve N. Kalkanis, Michael Lewis, Chaya Brodie
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Background: There is a compelling evidence from animal models that early exposure to clinically relevant general anesthetics (GAs) interferes with brain development, resulting in long-lasting cognitive impairments. Human studies have been inconclusiv
Externí odkaz:
https://doaj.org/article/4860c488a6ca4275b35319a114cee037
Autor:
Sonja Lj. Joksimovic, J. Grayson Evans, William E. McIntire, Peihan Orestes, Paula Q. Barrett, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Our previous studies implicated glycosylation of the CaV3.2 isoform of T-type Ca2+ channels (T-channels) in the development of Type 2 painful peripheral diabetic neuropathy (PDN). Here we investigated biophysical mechanisms underlying the modulation
Externí odkaz:
https://doaj.org/article/9ccc9c7e8875442c83d807ce0d40535f
Autor:
Stefan Maksimovic, Nemanja Useinovic, Nidia Quillinan, Douglas F. Covey, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1889 (2022)
Over the past three decades, we have been grappling with rapidly accumulating evidence that general anesthetics (GAs) may not be as innocuous for the young brain as we previously believed. The growing realization comes from hundreds of animal studies
Externí odkaz:
https://doaj.org/article/aeb6834b851a41a1aa09151fa548dd71