Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Vesna Blazevic"'
Autor:
Vili Lampinen, Stina Gröhn, Saana Soppela, Vesna Blazevic, Vesa P. Hytönen, Minna M. Hankaniemi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionVirus-like particles (VLPs) are similar in size and shape to their respective viruses, but free of viral genetic material. This makes VLP-based vaccines incapable of causing infection, but still effective in mounting immune responses. Nor
Externí odkaz:
https://doaj.org/article/94f5124595364cfe978e6e8947428194
Autor:
Isabel Leroux-Roels, Cathy Maes, Jasper Joye, Bart Jacobs, Franziska Jarczowski, André Diessner, Yorick Janssens, Gwenn Waerlop, Kirsi Tamminen, Suvi Heinimäki, Vesna Blazevic, Geert Leroux-Roels, Victor Klimyuk, Hiroshi Adachi, Kazuyuki Hiruta, Frank Thieme
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Noroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans worldwide and a safe and effective vaccine is needed. Here, a phase I, double-blind, placebo-controlled clinical trial was performed in 60 healthy adults, 18 to 40 ye
Externí odkaz:
https://doaj.org/article/bb6df2d5e1e744729c3ccc75dafbda24
Autor:
Vili Lampinen, Suvi Heinimäki, Olli H. Laitinen, Marko Pesu, Minna M. Hankaniemi, Vesna Blazevic, Vesa P. Hytönen
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Virus-like particle (VLP) vaccines have recently emerged as a safe and effective alternative to conventional vaccine technologies. The strong immunogenic effects of VLPs can be harnessed for making vaccines against any pathogen by
Externí odkaz:
https://doaj.org/article/ffa2db15f11a40eca0c3dce791cdb813
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
We have previously shown that rotavirus (RV) inner capsid protein VP6 has an adjuvant effect on norovirus (NoV) virus-like particle- (VLP-) induced immune responses and studied the adjuvant mechanism in immortalized cell lines used as antigen-present
Externí odkaz:
https://doaj.org/article/56de68a6fab74eb6b38589c3a759f586
Publikováno v:
Vaccines, Vol 9, Iss 7, p 733 (2021)
Vaccines based on mRNA and viral vectors are currently used in the frontline to combat the ongoing pandemic caused by the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). However, there is still an urgent need for alternative vacci
Externí odkaz:
https://doaj.org/article/e3b59fa5129f4ca69725b475c5ac25dd
Publikováno v:
Vaccines, Vol 8, Iss 3, p 365 (2020)
Novel adjuvants present a concern for adverse effects, generating a need for alternatives. Rotavirus inner capsid VP6 protein could be considered a potential candidate, due to its ability to self-assemble into highly immunogenic nanospheres and nanot
Externí odkaz:
https://doaj.org/article/c80a5462ef0e4bab93b087dc49dbcc9e
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Norovirus (NoV) causes a substantial global burden of acute gastroenteritis in all age groups and the development of NoV vaccine is a high priority. There are still gaps in understanding of protective NoV-specific immunity. Antibody mediated immune r
Externí odkaz:
https://doaj.org/article/036499a36aee4349a0bc5f71800ba837
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
Norovirus (NoV) is a main cause of acute gastroenteritis across all ages worldwide. NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). Since No
Externí odkaz:
https://doaj.org/article/817f2c612ed1437bac71020de68f08d0
Publikováno v:
Viruses, Vol 11, Iss 11, p 1018 (2019)
Human noroviruses (NoVs) are a genetically diverse, constantly evolving group of viruses. Here, we studied the effect of NoV pre-existing immunity on the success of NoV vaccinations with genetically close and distant genotypes. A sequential immunizat
Externí odkaz:
https://doaj.org/article/982f8d41c5cd4729892504aed32b294a
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 229 (2019)
Rotaviruses (RVs) and noroviruses (NoVs) are major causes of childhood acute gastroenteritis. During development of a combination vaccine based on NoV virus-like particles (VLP) and RV VP6 produced in baculovirus expression system in insect cells, a
Externí odkaz:
https://doaj.org/article/a940c55b204d4dbbaafb26de87bef34d