Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Vesa Turkki"'
Autor:
Anniina J. Valkama, Igor Oruetxebarria, Eevi M. Lipponen, Hanna M. Leinonen, Piia Käyhty, Heidi Hynynen, Vesa Turkki, Joonas Malinen, Tuukka Miinalainen, Tommi Heikura, Nigel R. Parker, Seppo Ylä-Herttuala, Hanna P. Lesch
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 717-730 (2020)
The interest in lentiviral vectors (LVs) has increased prominently for gene therapy applications, but few have reached the later stages of clinical trials. The main challenge has remained in scaling up the manufacturing process for the fragile vector
Externí odkaz:
https://doaj.org/article/7677766b879b48a5baadae07e874d057
Autor:
Hanna M. Leinonen, Eevi M. Lipponen, Anniina J. Valkama, Heidi Hynynen, Igor Oruetxebarria, Vesa Turkki, Venla Olsson, Jere Kurkipuro, Haritha Samaranayake, Ann-Marie Määttä, Nigel R. Parker, Seppo Ylä-Herttuala, Hanna P. Lesch
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 63-71 (2019)
The therapeutic efficacy of a lentiviral vector (LV) expressing the herpes simplex virus thymidine kinase (HSV-TK) was studied in an immunocompetent rat glioblastoma model. Intraperitoneal ganciclovir injections (50 mg/kg/day) were administered for 1
Externí odkaz:
https://doaj.org/article/58e30f80fca14c09842389d436188547
Publikováno v:
Viruses, Vol 13, Iss 5, p 939 (2021)
Virus particle concentration is a critical piece of information for virology, viral vaccines and gene therapy research. We tested a novel nanoparticle counting device, “Videodrop”, for its efficacy in titering and characterization of virus partic
Externí odkaz:
https://doaj.org/article/7c4a4fd489b848d5a4e735c648cfcc78
Autor:
Kushol Gupta, Vesa Turkki, Scott Sherrill-Mix, Young Hwang, Grant Eilers, Louis Taylor, Charlene McDanal, Ping Wang, David Temelkoff, Robert T Nolte, Emile Velthuisen, Jerry Jeffrey, Gregory D Van Duyne, Frederic D Bushman
Publikováno v:
PLoS Biology, Vol 14, Iss 12, p e1002584 (2016)
The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV r
Externí odkaz:
https://doaj.org/article/2cbb091ccf0f4d93acbf92ec4b7cdc75
Autor:
Eevi M. Lipponen, Tommi Heikura, Igor Oruetxebarria, Vesa Turkki, Piia Käyhty, Heidi Hynynen, Joonas Malinen, Anniina J. Valkama, Tuukka Miinalainen, Hanna Leinonen, Hanna P. Lesch, Seppo Ylä-Herttuala, Nigel Parker
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 717-730 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 717-730 (2020)
The interest in lentiviral vectors (LVs) has increased prominently for gene therapy applications, but few have reached the later stages of clinical trials. The main challenge has remained in scaling up the manufacturing process for the fragile vector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55eadba3b60807f502fea59170137e10
https://doi.org/10.1016/j.omtm.2020.03.025
https://doi.org/10.1016/j.omtm.2020.03.025
Autor:
Heidi Hynynen, Haritha Samaranayake, Ann-Marie Määttä, Jere Kurkipuro, Hanna Leinonen, Anniina J. Valkama, Nigel Parker, Venla Olsson, Seppo Ylä-Herttuala, Hanna P. Lesch, Vesa Turkki, Eevi M. Lipponen, Igor Oruetxebarria
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss, Pp 63-71 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The therapeutic efficacy of a lentiviral vector (LV) expressing the herpes simplex virus thymidine kinase (HSV-TK) was studied in an immunocompetent rat glioblastoma model. Intraperitoneal ganciclovir injections (50 mg/kg/day) were administered for 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1273e3effced8f696cd6693e45905116
http://www.sciencedirect.com/science/article/pii/S2329050119300865
http://www.sciencedirect.com/science/article/pii/S2329050119300865
Publikováno v:
Viruses
Volume 13
Issue 5
Viruses, Vol 13, Iss 939, p 939 (2021)
Volume 13
Issue 5
Viruses, Vol 13, Iss 939, p 939 (2021)
Virus particle concentration is a critical piece of information for virology, viral vaccines and gene therapy research. We tested a novel nanoparticle counting device, “Videodrop”, for its efficacy in titering and characterization of virus partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91ad78a47a951a178745968a5b761a1
https://doi.org/10.3390/v13050939
https://doi.org/10.3390/v13050939
Autor:
Kushol Gupta, Frederic D. Bushman, Gregory D. Van Duyne, Grant Eilers, Young Hwang, Vesa Turkki
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:a410-a410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb13ea5fabc1f8ae97d396f77e070ae9
https://doi.org/10.1107/s0108767317096003
https://doi.org/10.1107/s0108767317096003
Autor:
Vesa Turkki, Kari J. Airenne, Seppo Ylä-Herttuala, Diana Schenkwein, Mervi K. Ahlroth, Oskari Timonen
Publikováno v:
Nucleic Acids Research
Integrating viral vectors are efficient gene transfer tools, but their integration patterns have been associated with genotoxicity and oncogenicity. The recent development of highly specific designer nucleases has enabled target DNA modification and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda9a0f245bc2bafdb7b869ab39b129b
https://doi.org/10.1093/nar/gks1438
https://doi.org/10.1093/nar/gks1438
Publikováno v:
Human Gene Therapy; May2010, Vol. 21 Issue 5, p589-602, 14p