Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Vesa P. HYTÖNEN"'
Autor:
Paula Turkki, Iftekhar Chowdhury, Tiina Öhman, Latifeh Azizi, Markku Varjosalo, Vesa P. Hytönen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Integrin adaptor proteins, like tensin-2, are crucial for cell adhesion and signaling. However, the function of tensin-2 beyond localizing to focal adhesions remain poorly understood. We utilized proximity-dependent biotinylation and Strep-t
Externí odkaz:
https://doaj.org/article/2a382a2d36db49af9d439a20dfaefb33
Autor:
Xiaochuan Wang, Zbigniew Baster, Latifeh Azizi, Liqing Li, Zenon Rajfur, Vesa P. Hytönen, Cai Huang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Talin2 is localized to large focal adhesions and is indispensable for traction force generation, invadopodium formation, cell invasion as well as metastasis. Talin2 has a higher affinity toward β-integrin tails than talin1. Moreover, disrup
Externí odkaz:
https://doaj.org/article/8c042807ea3146289db5210edeaf6fa7
Autor:
Argyro Bizaki-Vallaskangas, Joel Rämö, Eeva Sliz, Ilkka Kivekäs, Tytti Willberg, Elmo Saarentaus, Sanna Toppila-Salmi, Aarno Dietz, Teppo Haapaniemi, Vesa P. Hytönen, Sari Toivola, Aarno Palotie, Antti Mäkitie, Johannes Kettunen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract To evaluate the genetics of chronic nonsuppurative otitis media (OM). We performed a genome-wide association study of 429,599 individuals included in the FinnGen study using three different case definitions: combined chronic nonsuppurative O
Externí odkaz:
https://doaj.org/article/c900bb12cbae45809bc6e06bc2152968
Publikováno v:
Biosensors and Bioelectronics: X, Vol 21, Iss , Pp 100556- (2024)
Biosensors are used in various applications in the field of medicine, environmental monitoring, and chemical processing to study the concentration and quality of target molecules. Biosensors convert the interaction between a specific target molecule
Externí odkaz:
https://doaj.org/article/af98bd2f0bd74a36912db7339cd7340a
Autor:
Vili Lampinen, Stina Gröhn, Nina Lehmler, Minne Jartti, Vesa P. Hytönen, Maren Schubert, Minna M. Hankaniemi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Insect cells have long been the main expression host of many virus-like particles (VLP). VLPs resemble the respective viruses but are non-infectious. They are important in vaccine development and serve as safe model systems in virus research
Externí odkaz:
https://doaj.org/article/210d55cee6034350b5095386ed69dad3
Autor:
Virginia Alessandra Gobbo, Amel Houaoui, Kimiya Tajik, Vesa P. Hytönen, Susanna Miettinen, Jonathan Massera
Publikováno v:
Applied Surface Science Advances, Vol 23, Iss , Pp 100635- (2024)
Orthopedic disorders are increasing in our society due to population aging. Numerous biomaterials have been developed to support bone regeneration, however showing a strong discrepancy between in vitro and in vivo results. This has been attributed to
Externí odkaz:
https://doaj.org/article/103fbf0234174163b60c480cedb378f5
Autor:
Adama Sidibé, Vasyl V. Mykuliak, Pingfeng Zhang, Vesa P. Hytönen, Jinhua Wu, Bernhard Wehrle-Haller
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110129- (2024)
Summary: Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical for controlling endothelial permeability and proliferation in cancer and inflammatory diseases but remains poorly understood. Here, we investigate
Externí odkaz:
https://doaj.org/article/475720b9bb7b45a99cb9f6554b8b4c45
Thrombus Aspirates From Patients With Acute Ischemic Stroke Are Infiltrated by Viridans Streptococci
Autor:
Olli Patrakka, Sari Tuomisto, Juha‐Pekka Pienimäki, Jyrki Ollikainen, Niku Oksala, Vili Lampinen, Markus J. T. Ojanen, Heini Huhtala, Vesa P. Hytönen, Terho Lehtimäki, Mika Martiskainen, Pekka J. Karhunen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 22 (2023)
Background Acute ischemic stroke may be due to embolism from ruptured atherosclerotic carotid arteries. DNA of oral bacteria, mainly the viridans streptococci group, has been detected in thrombus aspirates of patients with ischemic stroke as well as
Externí odkaz:
https://doaj.org/article/ad89ce4cadac4bd990d21bfc98acce40
Autor:
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Tumour suppressors are inhibited in cancers and their reactivation could provide novel therapy opportunities. Here, the authors study the structural mechanism by which human tumour suppressor Protein Phosphatase 2A is inhibited in breast cancer cells
Externí odkaz:
https://doaj.org/article/a40d0289287e4365ac202e20daf82ec2
Autor:
Vili Lampinen, Stina Gröhn, Saana Soppela, Vesna Blazevic, Vesa P. Hytönen, Minna M. Hankaniemi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionVirus-like particles (VLPs) are similar in size and shape to their respective viruses, but free of viral genetic material. This makes VLP-based vaccines incapable of causing infection, but still effective in mounting immune responses. Nor
Externí odkaz:
https://doaj.org/article/94f5124595364cfe978e6e8947428194