Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Vesa Aho"'
Autor:
Simon Leclerc, Alka Gupta, Visa Ruokolainen, Jian-Hua Chen, Kari Kunnas, Axel A Ekman, Henri Niskanen, Ilya Belevich, Helena Vihinen, Paula Turkki, Ana J Perez-Berna, Sergey Kapishnikov, Elina Mäntylä, Maria Harkiolaki, Eric Dufour, Vesa Hytönen, Eva Pereiro, Tony McEnroe, Kenneth Fahy, Minna U Kaikkonen, Eija Jokitalo, Carolyn A Larabell, Venera Weinhardt, Salla Mattola, Vesa Aho, Maija Vihinen-Ranta
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1011829 (2024)
Viruses target mitochondria to promote their replication, and infection-induced stress during the progression of infection leads to the regulation of antiviral defenses and mitochondrial metabolism which are opposed by counteracting viral factors. Th
Externí odkaz:
https://doaj.org/article/487e2f24f96c4045ac1e8396fe49fa50
Autor:
Lionel Galibert, Amira Hyvönen, Reetta A. E. Eriksson, Salla Mattola, Vesa Aho, Sami Salminen, Justin D. Albers, Sanna K. Peltola, Saija Weman, Tiina Nieminen, Seppo Ylä-Herttuala, Hanna P. Lesch, Maija Vihinen-Ranta, Kari J. Airenne
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract With a limited coding capacity of 4.7 kb, adeno-associated virus (AAV) genome has evolved over-lapping genes to maximise the usage of its genome. An example is the recently found ORF in the cap gene, encoding membrane-associated accessory pr
Externí odkaz:
https://doaj.org/article/cfb778447b9c4cc69e2061b9fd481166
Autor:
Salla Mattola, Elina Mäntylä, Vesa Aho, Sami Salminen, Simon Leclerc, Mikko Oittinen, Kari Salokas, Jani Järvensivu, Satu Hakanen, Teemu O Ihalainen, Keijo Viiri, Maija Vihinen-Ranta
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The nuclear export factor CRM1-mediated pathway is known to be important for the nuclear egress of progeny parvovirus capsids in the host cells with virus-mediated cell cycle arrest at G2/M. However, it is still unclear whether this is the only pathw
Externí odkaz:
https://doaj.org/article/11ba14f8b1f84f0fad394eeb8e023c94
Autor:
Salla Mattola, Kari Salokas, Vesa Aho, Elina Mäntylä, Sami Salminen, Satu Hakanen, Einari A Niskanen, Julija Svirskaite, Teemu O Ihalainen, Kari J Airenne, Minna Kaikkonen-Määttä, Colin R Parrish, Markku Varjosalo, Maija Vihinen-Ranta
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010353 (2022)
Autonomous parvoviruses encode at least two nonstructural proteins, NS1 and NS2. While NS1 is linked to important nuclear processes required for viral replication, much less is known about the role of NS2. Specifically, the function of canine parvovi
Externí odkaz:
https://doaj.org/article/7ff487106da443a699fc2c1d82e0fe85
Autor:
Vesa Aho, Sami Salminen, Salla Mattola, Alka Gupta, Felix Flomm, Beate Sodeik, Jens B Bosse, Maija Vihinen-Ranta
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010132 (2021)
Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properti
Externí odkaz:
https://doaj.org/article/c690cb1cb8fd4051bd72d5ee40577eb2
Autor:
Jian-Hua Chen, Bieke Vanslembrouck, Axel Ekman, Vesa Aho, Carolyn A. Larabell, Mark A. Le Gros, Maija Vihinen-Ranta, Venera Weinhardt
Publikováno v:
Viruses, Vol 14, Iss 12, p 2651 (2022)
Upon infection, viruses hijack the cell machinery and remodel host cell structures to utilize them for viral proliferation. Since viruses are about a thousand times smaller than their host cells, imaging virus-host interactions at high spatial resolu
Externí odkaz:
https://doaj.org/article/7d1f06bf5cef4e51a946d69fcc3a9b36
Autor:
Salla Mattola, Satu Hakanen, Sami Salminen, Vesa Aho, Elina Mäntylä, Teemu O. Ihalainen, Michael Kann, Maija Vihinen-Ranta
Publikováno v:
Viruses, Vol 13, Iss 7, p 1306 (2021)
Parvoviruses are small single-stranded (ss) DNA viruses, which replicate in the nucleoplasm and affect both the structure and function of the nucleus. The nuclear stage of the parvovirus life cycle starts at the nuclear entry of incoming capsids and
Externí odkaz:
https://doaj.org/article/51253804ef3a49828d1c0a7c5c7a93c8
Autor:
Vesa Aho, Markko Myllys, Visa Ruokolainen, Satu Hakanen, Elina Mäntylä, Jori Virtanen, Veijo Hukkanen, Thomas Kühn, Jussi Timonen, Keijo Mattila, Carolyn A. Larabell, Maija Vihinen-Ranta
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Various types of DNA viruses are known to elicit the formation of a large nuclear viral replication compartment and marginalization of the cell chromatin. We used three-dimensional soft x-ray tomography, confocal and electron microscopy, com
Externí odkaz:
https://doaj.org/article/6fc9b143eefe40759c570e5b44160ee8
Autor:
Vesa Aho, Elina Mäntylä, Axel Ekman, Satu Hakanen, Salla Mattola, Jian-Hua Chen, Venera Weinhardt, Visa Ruokolainen, Beate Sodeik, Carolyn Larabell, Maija Vihinen-Ranta
Publikováno v:
Viruses, Vol 11, Iss 10, p 935 (2019)
During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm. We have shown previously that HSV-1 infection induces the formation
Externí odkaz:
https://doaj.org/article/520d04d11c93468c8523680608e82d5d
Autor:
Salla Mattola, Vesa Aho, Luisa F. Bustamante‐Jaramillo, Edoardo Pizzioli, Michael Kann, Maija Vihinen‐Ranta
Publikováno v:
Molecular microbiologyREFERENCES. 118(4)
Parvoviruses are small non-enveloped single-stranded DNA viruses, which depend on host cell nuclear transcriptional and replication machinery. After endosomal exposure of nuclear localization sequence and a phospholipase A2 domain on the capsid surfa