Plasmodium knowlesi as a model system for characterising Plasmodium vivax drug resistance candidate genes.

Autor: Verzier, Lisa H.¹, Coyle, Rachael¹, Singh, Shivani¹, Sanderson, Theo¹ theo@theo.io, Rayner, Julian C.¹ julian.rayner@sanger.ac.uk

Publikováno v: PLoS Neglected Tropical Diseases. 6/3/2019, Vol. 13 Issue 6, p1-23. 23p.

The Malaria Cell Atlas: single parasite transcriptomes across the complete Plasmodium life cycle

Autor: Howick, Virginia M., Russell, Andrew J.C., Andrews, Tallulah, Heaton, Haynes, Reid, Adam J., Natarajan, Kedar, Butungi, Hellen, Metcalf, Tom, Verzier, Lisa H., Rayner, Julian C., Berriman, Matthew, Herren, Jeremy K., Billker, Oliver, Hemberg, Martin, Talman, Arthur M., Lawniczak, Mara K.N.

Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::08f61df7828c91d28341eefdaa6a0c2b
https://eprints.gla.ac.uk/195058/1/195058.pdf

Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates

Autor: Ndegwa, Duncan N., Kundu, Prasun, Hostetler, Jessica B., Marin-Menendez, Alejandro, Sanderson, Theo, Mwikali, Kioko, Verzier, Lisa H., Coyle, Rachael, Adjalley, Sophie, Rayner, Julian C.

Plasmodium vivax is responsible for the majority of malaria cases outside Africa. Unlike P. falciparum, the P. vivax life-cycle includes a dormant liver stage, the hypnozoite, which can cause infection in the absence of mosquito transmission. An effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12ecacf5cceeb61cc1c7e73582472a42

Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates

Autor: Rachael Coyle, Duncan N. Ndegwa, Julian C. Rayner, Alejandro Marin-Menendez, Jessica B. Hostetler, Lisa H. Verzier, Theo Sanderson, Sophie H. Adjalley, Kioko Mwikali, Prasun Kundu

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1008864 (2021)

Plasmodium vivax is responsible for the majority of malaria cases outside Africa. Unlike P. falciparum, the P. vivax life-cycle includes a dormant liver stage, the hypnozoite, which can cause infection in the absence of mosquito transmission. An effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604bc7ed85297790fce1a1799d943ec3
https://www.repository.cam.ac.uk/handle/1810/325617

The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle.

Autor: Howick VM; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Russell AJC; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Andrews T; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Heaton H; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Reid AJ; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Natarajan K; Danish Institute of Advanced Study (D-IAS), Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Butungi H; International Centre of Insect Physiology and Ecology (icipe), Nairobi, Kenya.; Wits Research Institute for Malaria, MRC Collaborating Centre for Multi-disciplinary Research on Malaria, School of Pathology, Faculty of Health Sciences, University of the Witswatersrand, Johannesburg, South Africa., Metcalf T; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Verzier LH; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Rayner JC; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Berriman M; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Herren JK; International Centre of Insect Physiology and Ecology (icipe), Nairobi, Kenya.; Wits Research Institute for Malaria, MRC Collaborating Centre for Multi-disciplinary Research on Malaria, School of Pathology, Faculty of Health Sciences, University of the Witswatersrand, Johannesburg, South Africa.; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Billker O; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.; Laboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå University, Umeå, Sweden., Hemberg M; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Talman AM; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.; MIVEGEC, IRD, CNRS, University of Montpellier, Montpellier, France., Lawniczak MKN; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK. mara@sanger.ac.uk.

Publikováno v: Science (New York, N.Y.) [Science] 2019 Aug 23; Vol. 365 (6455).