¹³ C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells.

Autor: Ma EH; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Dahabieh MS; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., DeCamp LM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Kaymak I; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Kitchen-Goosen SM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Oswald BM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Longo J; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Roy DG; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada., Verway MJ; Goodman Cancer Institute, Faculty of Medicine, McGill University, Montréal, QC, Canada., Johnson RM; Gilead Sciences Inc., Foster City, CA, USA., Samborska B; Goodman Cancer Institute, Faculty of Medicine, McGill University, Montréal, QC, Canada., Duimstra LR; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Scullion CA; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA., Steadman M; Agios Pharmaceuticals, Cambridge, MA, USA., Vos M; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Roddy TP; Agios Pharmaceuticals, Cambridge, MA, USA., Krawczyk CM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Williams KS; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA., Sheldon RD; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA.; Mass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA., Jones RG; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.; Metabolism and Nutrition (MeNu) Program, Van Andel Institute, Grand Rapids, MI, USA.

Publikováno v: Science advances [Sci Adv] 2024 May 31; Vol. 10 (22), pp. eadj1431. Date of Electronic Publication: 2024 May 29.

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8 ⁺ T Cells.

Autor: Ma EH; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Verway MJ; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Johnson RM; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada., Roy DG; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Steadman M; Agios Pharmaceuticals, Cambridge, MA 02139, USA., Hayes S; Agios Pharmaceuticals, Cambridge, MA 02139, USA., Williams KS; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Sheldon RD; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA., Samborska B; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Kosinski PA; Agios Pharmaceuticals, Cambridge, MA 02139, USA., Kim H; Agios Pharmaceuticals, Cambridge, MA 02139, USA., Griss T; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Faubert B; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Condotta SA; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3G 1Y6, Canada; Microbiome and Disease Tolerance Centre, McGill University, Montreal, QC H3G 1Y6, Canada., Krawczyk CM; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3G 1Y6, Canada., DeBerardinis RJ; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Stewart KM; Agios Pharmaceuticals, Cambridge, MA 02139, USA., Richer MJ; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3G 1Y6, Canada; Microbiome and Disease Tolerance Centre, McGill University, Montreal, QC H3G 1Y6, Canada., Chubukov V; Agios Pharmaceuticals, Cambridge, MA 02139, USA., Roddy TP; Agios Pharmaceuticals, Cambridge, MA 02139, USA., Jones RG; Metabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI 49503, USA; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address: russell.jones@vai.org.

Publikováno v: Immunity [Immunity] 2019 Nov 19; Vol. 51 (5), pp. 856-870.e5. Date of Electronic Publication: 2019 Oct 10.

Serine Is an Essential Metabolite for Effector T Cell Expansion.

Autor: Ma EH; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Bantug G; Department of Biomedicine, Immunobiology, University of Basel, 4031 Basel, Switzerland., Griss T; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Condotta S; Department of Microbiology and Immunology, McGill University, Montreal, QC H3G 1Y6, Canada; Microbiome and Disease Tolerance Centre, McGill University, Montreal, QC H3G 1Y6, Canada., Johnson RM; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada., Samborska B; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Mainolfi N; Raze Therapeutics, 400 Technology Square, 10th Floor, Cambridge, MA 02139, USA., Suri V; Raze Therapeutics, 400 Technology Square, 10th Floor, Cambridge, MA 02139, USA., Guak H; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Balmer ML; Department of Biomedicine, Immunobiology, University of Basel, 4031 Basel, Switzerland., Verway MJ; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Raissi TC; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Tsui H; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Boukhaled G; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada., Henriques da Costa S; MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Frezza C; MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK., Krawczyk CM; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3G 1Y6, Canada., Friedman A; Raze Therapeutics, 400 Technology Square, 10th Floor, Cambridge, MA 02139, USA., Manfredi M; Raze Therapeutics, 400 Technology Square, 10th Floor, Cambridge, MA 02139, USA., Richer MJ; Department of Microbiology and Immunology, McGill University, Montreal, QC H3G 1Y6, Canada; Microbiome and Disease Tolerance Centre, McGill University, Montreal, QC H3G 1Y6, Canada., Hess C; Department of Biomedicine, Immunobiology, University of Basel, 4031 Basel, Switzerland., Jones RG; Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address: russell.jones@mcgill.ca.

Publikováno v: Cell metabolism [Cell Metab] 2017 Feb 07; Vol. 25 (2), pp. 345-357. Date of Electronic Publication: 2017 Jan 19.