Výsledky vyhledávání - "Veruska Lia Fook Alves"

Transcriptome Analysis of Mesenchymal Stem Cells from Multiple Myeloma Patients Reveals Downregulation of Genes Involved in Cell Cycle Progression, Immune Response, and Bone Metabolism

Autor: Rodrigo Carlini Fernando, Veruska Lia Fook Alves, Edgar Gil Rizzatti, Hatylas Azevedo, Alex Freire Sandes, David Martins, Gisele W. B. Colleoni, Maria Aparecida Dalboni, Diego R. Mazzotti, Mariana Bleker de Oliveira, Fabricio de Carvalho, Angela Isabel Pereira Eugênio

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)

A growing body of evidence suggests a key role of tumor microenvironment, especially for bone marrow mesenchymal stem cells (MSC), in the maintenance and progression of multiple myeloma (MM), through direct and indirect interactions with tumor plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be725b542496b99e6c1656c34439937c
http://europepmc.org/articles/PMC6355867

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Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?

Autor: Veruska Lia Fook Alves, Djordje Atanackovic, Bruna Raphaeli Silva, Gisele W. B. Colleoni, Walter Moises Tobias Braga, Adriana Bruscato Bortoluzo

Publikováno v: Immunotherapy. 6:569-575

Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor‐infiltrating T cells. Materials & methods: MAGE‐C1/CT‐7, MAGEA3/6, NY‐ESO‐1, LAGE‐1 and GAGE express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f95a839bf8d04cb5771257a1b19d11
https://doi.org/10.2217/imt.14.24

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Heat Shock Protein 70 Inhibitor, Alone or in Combination with Bortezomib, Prevented Plasmacytoma Development in Immunodeficient Mice Transplanted with Myeloma Cell Lines

Autor: Mariana Bleker de Oliveira, Daniela B Zanatta, Gisele W. B. Colleoni, Bryan E. Strauss, Veruska Lia Fook Alves, Angela Isabel Pereira Eugênio, Mihoko Yamamoto

Publikováno v: Blood. 128:5658-5658

Introduction: HSP70 has an integrative role in protein degradation due to the interaction with many pathways, such as ubiquitin proteasome (UPS), unfolded protein response (UPR) and autophagy. In multiple myeloma (MM) HSP70 is overexpressed and helps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70e141ec604a507fb943bea87f767c3b
https://doi.org/10.1182/blood.v128.22.5658.5658

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Multiple Myeloma Cancer Stem Cells: Immunophenotypic and Functional Characterization, Gene Expression Profiling and Therapeutic Targets

Autor: Daniela Teixeira, Rodrigo Carlini Fernando, Mihoko Yamamoto, Veruska Lia Fook Alves, Paola Marino Dantonio, Gisele W. B. Colleoni, Alexandre S. Basso, Mariana Bleker de Oliveira

Publikováno v: Blood. 128:4434-4434

Background: Despite the increase in patients' survival over the last years, multiple myeloma (MM) remains incurable, being persistence of cancer stem cells (CSCs) a probable cause of drug resistance and disease relapse. It is possible to isolate thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74e336ea2c1fa4b3b936e65f6aee3b46
https://doi.org/10.1182/blood.v128.22.4434.4434

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In Vitro JAK1/2 Inhibition, in Association with Bortezomib and Lenalidomide, Is Comparable with Bortezomib, Lenalidomide and Dexametasone: An Alternative for Multiple Myeloma Patients with JAK2 overexpression?

Autor: Mihoko Yamamoto, Angela Isabel Pereira Eugênio, Rodrigo Carlini Fernando, Veruska Lia Fook Alves, Mariana Bleker de Oliveira, Gisele W. B. Colleoni

Publikováno v: Blood. 128:5663-5663

Background: Despite the absence of JAK1 and JAK2 mutations in multiple myeloma (MM), high levels of IL-6 constitutively activate the JAK/STAT pathway promoting survival and proliferation of tumor cells. Therefore, pharmacological inhibition of JAK pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::878dff585607ec4253ab3f1feee7262a
https://doi.org/10.1182/blood.v128.22.5663.5663

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MAGE-C1/CT7 and MAGE-C2/CT10 are frequently expressed in multiple myeloma and can be explored in combined immunotherapy for this malignancy

Autor: Gisele W. B. Colleoni, Walter Moises Tobias Braga, Celso Vieira Xavier, Veruska Lia Fook Alves, Fabricio de Carvalho

Publikováno v: Cancer immunology, immunotherapy : CII. 62(1)

The exact function of MAGE-C1/CT7 and MAGE-C2/CT10 is not yet understood in multiple myeloma (MM). However, the homologs MAGE-C1/CT7 and MAGE-C2/CT10 genes encode highly immunogeneic cancer/testis antigens (CTAs) and can be potential targets for T ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d84069d6f6c1d2a0770698853601f2
https://pubmed.ncbi.nlm.nih.gov/23180015

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TRIAP1 (TP53 regulated inhibitor of apoptosis 1)

Autor: Veruska Lia Fook Alves, André Luiz Vettore, Roberta S. Felix, Gisele W. B. Colleoni

Publikováno v: Atlas of Genetics and Cytogenetics in Oncology and Haematology.

Review on TRIAP1 (TP53 regulated inhibitor of apoptosis 1), with data on DNA, on the protein encoded, and where the gene is implicated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9269c4d055c47b2996516ded5bbdb89
https://doi.org/10.4267/2042/46029

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Abstract 1017: Silencing of apoptosome regulating genes, HSP70 and TRIAP1, induces apoptosis in MM cell lines

Autor: Veruska Lia Fook Alves, Daniela B Zanatta, Bryan E. Strauss, Gisele W. B. Colleoni, Rodrigo Carlini Fernando, Angela Isabel Pereira Eugênio, Mariana Bleker de Oliveira

Publikováno v: Cancer Research. 75:1017-1017

Introduction: Some evidences suggest that heat shock protein 70 (HSP70) is overexpressed in many types of cancer, providing a selective advantage for tumor cell survival, due in part, to its ability to inhibit cell death via APAF1 (apoptosis protease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7860a0ad7c3db4b40b10664dba3f97d9
https://doi.org/10.1158/1538-7445.am2015-1017

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Silencing of HSP70 and TRIAP1 Genes in Multiple Myeloma Cell Lines Induces Apoptosis through Apaf-1/Caspase 9 Pathway: New Potential Targets on the Way?

Autor: Gisele W. B. Colleoni, Bryan E. Strauss, Veruska Lia Fook Alves, Daniela Bertolli Zanatta

Publikováno v: Blood. 124:5175-5175

Introduction: Some evidences suggest that heat shock protein 70 (HSP70) is overexpressed in many types of cancer, and that high expression of this chaperone is linked with increasing tumor grade and/or poor prognosis. The overexpression of HSP70 may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03066dd87d0ae4680c0c4d1d086feb4c
https://doi.org/10.1182/blood.v124.21.5175.5175

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Functional Studies Of Hsp70 Gene Expression In Multiple Myeloma Cell Lines Suggest That This Gene Inhibition Can Be a Potential Therapeutic Target, Independent Of 17p/p53 Status

Autor: Veruska Lia Fook Alves, Gisele W. B. Colleoni, Walter Moises Tobias Braga, Fabricio de Carvalho, Bryan E. Strauss, Maria de Lourdes Lopes Ferrari Chauffaille, Daniela Bertolli Zanatta

Publikováno v: Blood. 122:3771-3771

Introduction Some evidences show that HSP70 is overexpressed in many cancers, and that high expression of this chaperone correlates with increased tumor grade and/or poor prognosis. Overexpression of HSP70 can provide a selective survival advantage t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4656c4c55fd272ea327cfe45fca910d4
https://doi.org/10.1182/blood.v122.21.3771.3771

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