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Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders

Autor: Federica Moraca, Simona Marzano, Francesco D'Amico, Antonio Lupia, Silvia Di Fonzo, Eleonora Vertecchi, Erica Salvati, Anna Di Porzio, Bruno Catalanotti, Antonio Randazzo, Bruno Pagano, Jussara Amato

Publikováno v: Chemical Communications. 58:11913-11916

The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fe5d1eb600bdc863084b49eb9789e3
https://doi.org/10.1039/d2cc03135c

Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound

Autor: Bruno Pagano, Erica Salvati, Simona Marzano, Stefano De Tito, Eleonora Vertecchi, Jussara Amato, Anna Di Porzio, Nunzia Iaccarino, Antonio Randazzo

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10315, p 10315 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

DNA G-quadruplex (G4) structures, either within gene promoter sequences or at telomeres, have been extensively investigated as potential small-molecule therapeutic targets. However, although G4s forming at the telomeric DNA have been extensively inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f20cfa33c2d6415fc14d7a244f853ab
https://www.mdpi.com/1422-0067/22/19/10315