Disentangling the genetics of lean mass

Autor: Tuomas O. Kilpeläinen, Jacqueline S. L. Kloth, Nam H. Cho, Peter Vollenweider, Georg Homuth, Unnur Thorsteinsdottir, Nicole C. Wright, Wen-Chi Chou, Yongmei Liu, Kari Stefansson, Kim M. Huffman, Ida Malkin, Andrew P. Morris, Robert Luben, Shad B. Smith, Lei Yu, Joel Eriksson, Aarno Palotie, Veikko Salomaa, Michael J. Econs, Liesbeth Vandenput, Elizabeth A. Streeten, Albert Hofman, Elisabeth Widen, Emmi Tikkanen, Braxton D. Mitchell, Natasja M. van Schoor, Caroline Hayward, Liisa Byberg, Joanne M. Jordan, Bruce M. Psaty, Elisabeth Steinhagen-Thiessen, Magnus Karlsson, Harry Campbell, John C. Chambers, Fernando Rivadeneira, Johan G. Eriksson, Jari Lahti, Reiner Biffar, James F. Wilson, Luda Diatchenko, Jerome I. Rotter, Eric S. Orwoll, Launer J. Lenore, Cornelia M. van Duijn, Frances M K Williams, Munro Peacock, David A. Bennett, Annette Peters, Ali A. Aghdassi, Gudny Eiriksdottir, Weihua Zhang, Östen Ljunggren, Daniel L. Koller, Nicole Soranzo, Patricia A. Thompson, Jane A. Cauley, John A Robbins, Mattias Lorentzon, Igor Rudan, Thomas Illig, Claes Ohlsson, Ilja Demuth, Zoltán Kutalik, Aron S. Buchman, Jian'an Luan, Erik Ingelsson, Natalia Campos-Obando, Karol Estrada, Chan Soo Shin, Lisette Stolk, Gudmar Thorleifsson, Douglas P. Kiel, Michael N. Weedon, Lars Bertram, Fiona E. McGuigan, Ben A. Oostra, Thomas Meitinger, Mary F. Feitosa, Christian Gieger, Jean Wactawski-Wende, Yanhua Zhou, Serkalem Demissie, Najaf Amin, Anke W. Enneman, Håkan Melhus, Stuart H. Ralston, Johanna Kuusisto, Markku Laakso, Mark Walker, Tim D. Spector, Karl Michaëlsson, John-Olov Jansson, Richard L. Prince, Leif Mosekilde, Sabine Schipf, Carolina Medina-Gomez, Antti Jula, Carrie M. Nielson, Bente L. Langdahl, André G. Uitterlinden, Kay-Tee Khaw, Ruth J. F. Loos, Kristina Åkesson, Albert V. Smith, Tamara B. Harris, Cynthia A. Thomson, Karin M. A. Swart, Unnur Styrkarsdottir, Yi-Hsiang Hsu, Anne B. Newman, Murielle Bochud, M. Carola Zillikens, Alena Stančáková, Markus M. Lerch, Maria Nethander, Gregory Livshits, Dawn Waterworth, Christina M. Lill, Henry Völzke, Steven R. Cummings, Lise B. Husted, Cecilia M. Lindgren, Jaspal S. Kooner, Joshua R. Lewis, Katri Räikkönen, Linda Broer, Inês Barroso, Teemu Kuulasmaa, Jeffery R. O'Connell, Harald Grallert, William E. Kraus, Nicholas J. Wareham, Lars Lind, David Karasik, H-Erich Wichmann, Gregory J. Tranah, Mao Fu, Toby Johnson, Samuli Ripatti, Dan Mellström, Suzanne Satterfield, Jing Hua Zhao, Hyung Jin Choi, Vilmundur Gudnason, Lisette C. P. G. M. de Groot, Stephen B. Kritchevsky, Zhao Chen, Norman Klopp, Till Ittermann, Daniel S. Evans, Phillip L. De Jager, Ingrid B. Borecki, Laura M. Yerges-Armstrong, Peggy M. Cawthon, Thomas Lang, Markus Perola

Publikováno v: The American Journal of Clinical Nutrition
American Journal of Clinical Nutrition 109 (2019) 2
American Journal of Clinical Nutrition, 109(2), 276-287. American Society for Nutrition
American Journal of Clinical Nutrition, 276-287. American Society for Nutrition
STARTPAGE=276;ENDPAGE=287;ISSN=0002-9165;TITLE=American Journal of Clinical Nutrition
The American journal of clinical nutrition
Karasik, D, Zillikens, M C, Hsu, Y-H, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, D A, Bertram, L, Bochud, M, Borecki, I B, Broer, L, Buchman, A S, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, J A, Cawthon, P M, Chambers, J C, Chen, Z, Cho, N H, Choi, H J, Chou, W-C, Cummings, S R, de Groot, L C P G M, De Jager, P L, Demuth, I, Diatchenko, L, Econs, M J, Eiriksdottir, G, Enneman, A W, Eriksson, J, Eriksson, J G, Estrada, K, Evans, D S, Feitosa, M F, Fu, M, Gieger, C, Grallert, H, Gudnason, V, Lenore, L J, Hayward, C, Hofman, A, Homuth, G, Huffman, K M, Husted, L B, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J-O, Johnson, T, Biffar, R, Jordan, J M, Jula, A, Karlsson, M, Khaw, K-T, Kilpeläinen, T O, Klopp, N, Kloth, J S L, Koller, D L, Kooner, J S, Kraus, W E, Kritchevsky, S, Kutalik, Z, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, B L, Lerch, M M, Lewis, J R, Lill, C, Lind, L, Lindgren, C, Liu, Y, Livshits, G, Ljunggren, Ö, Loos, R J F, Lorentzon, M, Luan, J, Luben, R N, Malkin, I, McGuigan, F E, Medina-Gomez, C, Meitinger, T, Melhus, H, Mellström, D, Michaëlsson, K, Mitchell, B D, Morris, A P, Mosekilde, L, Nethander, M, Newman, A B, O'Connell, J R, Oostra, B A, Orwoll, E S, Palotie, A, Peacock, M, Perola, M, Peters, A, Prince, R L, Psaty, B M, Räikkönen, K, Ralston, S H, Ripatti, S, Rivadeneira, F, Robbins, J A, Rotter, J I, Rudan, I, Salomaa, V, Satterfield, S, Schipf, S, Shin, C S, Smith, A V, Smith, S B, Soranzo, N, Spector, T D, Stancáková, A, Stefansson, K, Steinhagen-Thiessen, E, Stolk, L, Streeten, E A, Styrkarsdottir, U, Swart, K M A, Thompson, P, Thomson, C A, Thorleifsson, G, Thorsteinsdottir, U, Tikkanen, E, Tranah, G J, Uitterlinden, A G, van Duijn, C M, van Schoor, N M, Vandenput, L, Vollenweider, P, Völzke, H, Wactawski-Wende, J, Walker, M, J Wareham, N, Waterworth, D, Weedon, M N, Wichmann, H-E, Widen, E, Williams, F M K, Wilson, J F, Wright, N C, Yerges-Armstrong, L M, Yu, L, Zhang, W, Zhao, J H, Zhou, Y, Nielson, C M, Harris, T B, Demissie, S, Kiel, D P & Ohlsson, C 2019, ' Disentangling the genetics of lean mass ', The American Journal of Clinical Nutrition, vol. 109, no. 2, pp. 276-287 . https://doi.org/10.1093/ajcn/nqy272
Karasik, D, Zillikens, M C, Hsu, Y H, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, D A, Swart, KMA, Bertram, L, Bochud, M, Borecki, I B, Broer, L, Buchman, A S, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, J A, Cawthon, P M, Chambers, J C, Chou, W C, Demuth, I, DIatchenko, L, Econs, M J, Eiriksdottir, G, Enneman, A W, Eriksson, J, Eriksson, J G, Chen, Z, Cho, N H, Choi, H J, Cummings, S R, de Groot, L C P G M, de Jager, P L, Estrada, K, Evans, D S, Feitosa, M F, Fu, M, Gieger, C, Grallert, H, Gudnason, V, Lenore, L J, Hayward, C, Hofman, A, Homuth, G, Huffman, K M, Husted, L B, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J O, Johnson, T, Biffar, R, Jordan, J M, Jula, A, Karlsson, M, Khaw, K T, Kilpeläinen, T O, Klopp, N, Kloth, J S L, Koller, D L, Kooner, J S, Kraus, W E, Kritchevsky, S, Kutalik, Z, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, B L, Lerch, M M, Lewis, J R, Lill, C M, Lind, L, Lindgren, C M, Liu, Y, Livshits, G, Ljunggren, O, Loos, R J F, Lorentzon, M, Luan, J, Luben, R N, Malkin, I, McGuigan, F E, Medina-Gómez, C, Meitinger, T, Melhus, H, Mellstrom, D, Michaelsson, K, Mitchell, B D, Morris, A P, Mosekilde, L, Nethander, M, Newman, A B, O'Connell, J R, Oostra, B A, Orwoll, E S, Palotie, A, Peacock, M, Perola, M, Peters, A, Prince, R L, Psaty, B M, Raikkonen, K, Ralston, S H, Ripatti, S, Rivadeneira, F, Robbins, J A, Rotter, J I, Rudan, I, Salomaa, V, Satterfield, S, Schipf, S, Shin, C S, Smith, A V, Smith, S, Soranzo, N, Spector, T D, Stancakova, A, Stefansson, K, Steinhagen-Thiessen, E, Stolk, L, Streeten, E A, Styrkarsdottir, U, Thompson, P, Thomson, C A, Thorleifsson, G, Thorsteinsdottir, U, Tikkanen, E, Tranah, G J, Uitterlinden, A G, van Duijn, C M, van Schoor, NM, Vandenput, L, Vollenweider, P, Volzke, H, Wactawski-Wende, J, Walker, M, J Wareham, N, Waterworth, D, Weedon, M N, Wichmann, H E, Widen, E, Williams, F M K, Wilson, J F, Wright, N C, Yerges-Armstrong, L M, Yu, L, Zhang, W, Zhao, J H, Zhou, Y, Nielson, C M, Harris, T B, Demissie, S, Kiel, D P & Ohlsson, C 2019, ' Disentangling the genetics of lean mass ', American Journal of Clinical Nutrition, pp. 276-287 .
Karasik, D, Zillikens, M C, Hsu, Y-H, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, D A, Bertram, L, Bochud, M, Borecki, I B, Broer, L, Buchman, A S, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, J A, Cawthon, P M, Chambers, J C, Chen, Z, Cho, N H, Choi, H J, Chou, W-C, Cummings, S R, de Groot, L C P G M, De Jager, P L, Demuth, I, Diatchenko, L, Econs, M J, Eiriksdottir, G, Enneman, A W, Eriksson, J, Eriksson, J G, Estrada, K, Evans, D S, Feitosa, M F, Fu, M, Gieger, C, Grallert, H, Gudnason, V, Lenore, L J, Hayward, C, Hofman, A, Homuth, G, Huffman, K M, Husted, L B, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J-O, Johnson, T, Biffar, R, Jordan, J M, Jula, A, Karlsson, M, Khaw, K-T, Kilpeläinen, T O, Klopp, N, Kloth, J S L, Koller, D L, Kooner, J S, Kraus, W E, Kritchevsky, S, Kutalik, Z, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, B L, Lerch, M M, Lewis, J R, Lill, C, Lind, L, Lindgren, C, Liu, Y, Livshits, G, Ljunggren, Ö, Loos, R J F, Lorentzon, M, Luan, J, Luben, R N, Malkin, I, McGuigan, F E, Medina-Gomez, C, Meitinger, T, Melhus, H, Mellström, D, Michaëlsson, K, Mitchell, B D, Morris, A P, Mosekilde, L, Nethander, M, Newman, A B, O'Connell, J R, Oostra, B A, Orwoll, E S, Palotie, A, Peacock, M, Perola, M, Peters, A, Prince, R L, Psaty, B M, Räikkönen, K, Ralston, S H, Ripatti, S, Rivadeneira, F, Robbins, J A, Rotter, J I, Rudan, I, Salomaa, V, Satterfield, S, Schipf, S, Shin, C S, Smith, A V, Smith, S B, Soranzo, N, Spector, T D, Stancáková, A, Stefansson, K, Steinhagen-Thiessen, E, Stolk, L, Streeten, E A, Styrkarsdottir, U, Swart, K M A, Thompson, P, Thomson, C A, Thorleifsson, G, Thorsteinsdottir, U, Tikkanen, E, Tranah, G J, Uitterlinden, A G, van Duijn, C M, van Schoor, N M, Vandenput, L, Vollenweider, P, Völzke, H, Wactawski-Wende, J, Walker, M, J Wareham, N, Waterworth, D, Weedon, M N, Wichmann, H-E, Widen, E, Williams, F M K, Wilson, J F, Wright, N C, Yerges-Armstrong, L M, Yu, L, Zhang, W, Zhao, J H, Zhou, Y, Nielson, C M, Harris, T B, Demissie, S, Kiel, D P & Ohlsson, C 2019, ' Disentangling the genetics of lean mass ', The American Journal of Clinical Nutrition (AJCN) . https://doi.org/10.1093/ajcn/nqy272
Karasik, D, Zillikens, M C, Hsu, Y-H, Aghdassi, A, Akesson, K, Amin, N, Barroso, I, Bennett, D A, Bertram, L, Bochud, M, Borecki, I B, Broer, L, Buchman, A S, Byberg, L, Campbell, H, Campos-Obando, N, Cauley, J A, Cawthon, P M, Chambers, J C, Chen, Z, Cho, N H, Choi, H J, Chou, W-C, Cummings, S R, de Groot, L C P G M, De Jager, P L, Demuth, I, Diatchenko, L, Econs, M J, Eiriksdottir, G, Enneman, A W, Eriksson, J, Eriksson, J G, Estrada, K, Evans, D S, Feitosa, M F, Fu, M, Gieger, C, Grallert, H, Gudnason, V, Lenore, L J, Hayward, C, Hofman, A, Homuth, G, Huffman, K M, Husted, L B, Illig, T, Ingelsson, E, Ittermann, T, Jansson, J-O, Johnson, T, Biffar, R, Jordan, J M, Jula, A, Karlsson, M, Khaw, K-T, Kilpeläinen, T O, Klopp, N, Kloth, J S L, Koller, D L, Kooner, J S, Kraus, W E, Kritchevsky, S, Kutalik, Z, Kuulasmaa, T, Kuusisto, J, Laakso, M, Lahti, J, Lang, T, Langdahl, B L, Lerch, M M, Lewis, J R, Lill, C, Lind, L, Lindgren, C, Liu, Y, Livshits, G, Ljunggren, Ö, Loos, R J F, Lorentzon, M, Luan, J, Luben, R N, Malkin, I, McGuigan, F E, Medina-Gomez, C, Meitinger, T, Melhus, H, Mellström, D, Michaëlsson, K, Mitchell, B D, Morris, A P, Mosekilde, L, Nethander, M, Newman, A B, O'Connell, J R, Oostra, B A, Orwoll, E S, Palotie, A, Peacock, M, Perola, M, Peters, A, Prince, R L, Psaty, B M, Räikkönen, K, Ralston, S H, Ripatti, S, Rivadeneira, F, Robbins, J A, Rotter, J I, Rudan, I, Salomaa, V, Satterfield, S, Schipf, S, Shin, C S, Smith, A V, Smith, S B, Soranzo, N, Spector, T D, Stancáková, A, Stefansson, K, Steinhagen-Thiessen, E, Stolk, L, Streeten, E A, Styrkarsdottir, U, Swart, K M A, Thompson, P, Thomson, C A, Thorleifsson, G, Thorsteinsdottir, U, Tikkanen, E, Tranah, G J, Uitterlinden, A G, van Duijn, C M, van Schoor, N M, Vandenput, L, Vollenweider, P, Völzke, H, Wactawski-Wende, J, Walker, M, J Wareham, N, Waterworth, D, Weedon, M N, Wichmann, H-E, Widen, E, Williams, F M K, Wilson, J F, Wright, N C, Yerges-Armstrong, L M, Yu, L, Zhang, W, Zhao, J H, Zhou, Y, Nielson, C M, Harris, T B, Demissie, S, Kiel, D P & Ohlsson, C 2019, ' Disentangling the genetics of lean mass ', The American journal of clinical nutrition, vol. 109, no. 2, pp. 276-287 . https://doi.org/10.1093/ajcn/nqy272
American Journal of Clinical Nutrition, 109(2), 276-278

Background: Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b768501bad6cfbb2327b96cc06a631
https://doi.org/10.1093/ajcn/nqy272