Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Versfelt, Joost W"'
Autor:
Witte, Wilhelmus E A1, Versfelt, Joost W1, Kuzikov, Maria2, Rolland, Solene3, Georgi, Victoria3, Gribbon, Philip2, Gul, Sheraz2, Huntjens, Dymphy4, Graaf, Piet Hein1,5, Danhof, Meindert1, Fernández‐Montalván, Amaury3,6, Witt, Gesa2, Lange, Elizabeth C M1 ecmdelange@lacdr.leidenuniv.nl, de Witte, Wilhelmus E A7 (AUTHOR), van der Graaf, Piet Hein7,8 (AUTHOR), Fernández-Montalván, Amaury9,10 (AUTHOR), de Lange, Elizabeth C M7 (AUTHOR)
Publikováno v:
British Journal of Pharmacology. Nov2018, Vol. 175 Issue 21, p4121-4136. 16p. 7 Diagrams, 3 Charts.
Autor:
de Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, van der Graaf, Piet Hein, Danhof, Meindert, Fernández‐Montalván, Amaury, Witt, Gesa, de Lange, Elizabeth C M
Publikováno v:
British Journal of Pharmacology
Background and Purpose Target binding kinetics influence the time course of the drug effect (pharmacodynamics) both (i) directly, by affecting the time course of target occupancy, driven by the pharmacokinetics of the drug, competition with endogenou