Výsledky vyhledávání - "Verschure, P.J."

Cell-to-Cell Transcription Variability as Measured by Single-Molecule RNA FISH to Detect Epigenetic State Switching

Autor: Beckman, W., Vuist, I.M., Kempe, H., Verschure, P.J., Jeltsch, A., Rots, M.G.

Publikováno v: Epigenome Editing
Methods in Molecular Biology
Methods in Molecular Biology-Epigenome Editing
Epigenome Editing: Methods and Protocols, 385-393
STARTPAGE=385;ENDPAGE=393;TITLE=Epigenome Editing
Methods in Molecular Biology ISBN: 9781493977734

Single-molecule RNA fluorescent in situ hybridization (smRNA FISH) allows for the visualization, localization, and quantification of RNA transcripts within individual cells and tissues using custom-designed fluorescently labeled oligonucleotide probe

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Epigenetic imprinting during assisted reproductive technologies: The effect of temporal and cumulative fluctuations in methionine cycling on the DNA methylation state

Autor: Hoeijmakers, L., Kempe, H., Verschure, P.J.

Publikováno v: Molecular Reproduction and Development, 83(2), 94-107. Wiley-Liss Inc.

Assisted reproductive technology (ART) exposes gametes and embryos to an artificial environment that does not resemble the conditions of natural conception, and therefore might change epigenetic regulation of genes that are imprinted during developme

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https://dare.uva.nl/personal/pure/en/publications/epigenetic-imprinting-during-assisted-reproductive-technologies-the-effect-of-temporal-and-cumulative-fluctuations-in-methionine-cycling-on-the-dna-methylation-state(06cbd10d-749e-4632-9cba-2657b692a6b8).html

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Mechanistic stochastic model of histone modification pattern formation

Autor: Anink-Groenen, L.C., Maarleveld, Timo, Verschure, P.J., Bruggeman, Frank

Publikováno v: Epigenetics & Chromatin, 7(30)

\noindent \textbf{Background} \\ The activity of a single gene is influenced by the composition of the chromatin in which it is embedded. Nucleosome turnover, conformational dynamics, and covalent histone modifications each induce changes in the stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::18a853524c016fd7ebac9edeb79c85bd
https://ir.cwi.nl/pub/22650

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Origins of stochastic intracellular processes and consequences for cell-to-cell variability and cellular survival strategies

Autor: Schwabe, Anne, Dobrzynski, Maciej, Rybakova, K.N., Verschure, P.J., Bruggeman, Frank, Jameson, D, Westerhoff, Hans

Quantitative analyses of the dynamics of single cells have become a powerful approach in current cell biology. They give us an unprecedented opportunity to study dynamics of molecular networks at a high level of accuracy in living single cells. Genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::69829431ed7f7fbf13cf1a43bde08d9a
https://ir.cwi.nl/pub/19080

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Origins of stochastic intracellular processes and consequences for cell-to-cell variability and cellular survival strategies

Autor: Schwabe, A., Dobrzynski, M., Rybakova, E., Verschure, P.J., Bruggeman, F.J.

Publikováno v: Methods in Enzymology, 500, 597-625. Academic Press Inc.

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https://dare.uva.nl/personal/pure/en/publications/origins-of-stochastic-intracellular-processes-and-consequences-for-celltocell-variability-and-cellular-survival-strategies(a007c076-e04d-48e4-af8a-4b6225bf48db).html

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Chromosome organization and gene control: It is difficult to see the picture when you are inside the frame

Autor: Verschure, P.J.

Publikováno v: Journal of Cellular Biochemistry, 99(1), 23-34. Wiley-Liss Inc.

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https://dare.uva.nl/personal/pure/en/publications/chromosome-organization-and-gene-control-it-is-difficult-to-see-the-picture-when-you-are-inside-the-frame(ec3a530b-1784-4e3f-978f-4412bf8ecd0b).html

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Step out of the groove: epigenetic gene control systems and engineered transcription factors

Autor: Verschure, P.J., Visser, A.E., Rots, M.G.

Publikováno v: Advances in Genetics Incorporating Molecular Genetic Medicine, 56, 163-204. Academic Press Inc.

At the linear DNA level, gene activity is believed to be driven by binding of transcription factors, which subsequently recruit the RNA polymerase to the gene promoter region. However, it has become clear that transcriptional activation involves larg

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Step into the groove: engineered transcription factors as modulators of gene expression

Autor: Visser, A.E., Verschure, P.J., Gommans, W.M., Haisma, H.J., Rots, M.G.

Publikováno v: Advances in Genetics Incorporating Molecular Genetic Medicine, 56, 131-161. Academic Press Inc.

Increasing knowledge about the influence of dysregulated gene expression in causing numerous diseases opens up new possibilities for the development of innovative therapeutics. In this chapter, we first describe different mechanisms of misregulated g

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