DOSAGE study: protocol for a phase III non-inferiority randomised trial investigating dose-reduced chemotherapy for advanced colorectal cancer in older patients.

Autor: Baltussen JC; Department of Medical Oncology, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands., van den Bos F; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; LUMC Center for Medicine for Older People, Leiden University Medical Centre, Leiden, The Netherlands., Slingerland M; Department of Medical Oncology, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands., Binda TRR; Department of Medical Oncology, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands., Liefers GJ; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., van den Hout WB; Department of Biomedical Data Sciences, Section of Medical Decision Making, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands., Fiocco M; Department of Biomedical Data Sciences, Section of Medical Statistics and Bioinformatics, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands.; Mathematical Institute, Leiden University, Leiden, The Netherlands., Verschoor AJ; Department of Medical Oncology, Reinier de Graaf Hospital, Delft, The Netherlands., Cloos-van Balen M; Department of Internal Medicine, Groene Hart Ziekenhuis, Gouda, Zuid-Holland, The Netherlands., Holterhues C; Department of Medical Oncology, Haga Hospital, Den Haag, The Netherlands., Houtsma D; Department of Medical Oncology, Haga Hospital, Den Haag, The Netherlands., Jochems A; Department of Medical Oncology, Medisch Centrum Haaglanden Westeinde, Den Haag, Zuid-Holland, The Netherlands., Spierings LEAMM; Department of Internal Medicine, Alrijne Hospital Leiden, Leiden, Zuid-Holland, The Netherlands., van Bodegom-Vos L; Department of Biomedical Data Sciences, Section of Medical Decision Making, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands., Mooijaart SP; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; LUMC Center for Medicine for Older People, Leiden University Medical Centre, Leiden, The Netherlands., Gelderblom H; Department of Medical Oncology, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands., Speetjens FM; Department of Medical Oncology, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands., de Glas NA; Department of Medical Oncology, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands., Portielje JEA; Department of Medical Oncology, Leiden Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands j.e.a.portielje@lumc.nl.

Publikováno v: BMJ open [BMJ Open] 2024 Aug 13; Vol. 14 (8), pp. e089882. Date of Electronic Publication: 2024 Aug 13.

Visiedocument gebruik van biobeschikbaarheid in bodembeoordeling : Mogelijkheden voor metalen in bodem en waterbodem

Autor: Lijzen JPA, Verschoor AJ, Mesman M, de Boer PT, Osté L, Römkens P, DDB, M&V

Om te bepalen of de kwaliteit van een bodem geschikt is voor (her)gebruik, wordt een risicobeoordeling uitgevoerd. Daarmee wordt onder meer beoordeeld of de aanwezige metalen een risico vormen voor mens, plant en dier. Momenteel wordt hiervoor de tot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::b48a2fe420d5d37f510718ebe566e4fe
http://hdl.handle.net/10029/620840

Risk of venous thromboembolism and major bleeding in the clinical course of osteosarcoma and Ewing sarcoma.

Autor: Kaptein FHJ; Department of Medicine - Thrombosis & Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., Stals MAM; Department of Medicine - Thrombosis & Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., Evenhuis RE; Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, the Netherlands., Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Huisman MV; Department of Medicine - Thrombosis & Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., Karis DSA; Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, the Netherlands., Noten RWD; Department of Medicine - Thrombosis & Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., Cannegieter SC; Department of Medicine - Thrombosis & Hemostasis, Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Speetjens FM; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Verschoor AJ; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Versteeg HH; Department of Medicine - Thrombosis & Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., van de Sande MAJ; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands., Klok FA; Department of Medicine - Thrombosis & Hemostasis, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: f.a.klok@LUMC.nl.

Publikováno v: Thrombosis research [Thromb Res] 2023 Jan; Vol. 221, pp. 19-25. Date of Electronic Publication: 2022 Nov 18.

Systematic selection of a dose metric for metal-based nanoparticles

Autor: Verschoor, AJ, Harper, S, Delmaar, CJE, Park, MVDZ, Sips, AJAM, Vijver, MG, Peijnenburg, WJGM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cc36f6df10937f08950d452ebee7d34a
http://hdl.handle.net/10029/622963

Are We Speaking the Same Language? Recommendations for a Definition and Categorization Framework for Plastic Debris

Autor: Natalia P. Ivleva, Therese Karlsson, Martin Wagner, Maria Pia Herrling, Nanna B. Hartmann, Thorsten Hüffer, Maren C. Hess, Sinja Rist, Verschoor Aj, Richard C. Thompson, Amy Lusher, Martin Hassellöv, Anders Egede Daugaard, Nicole Brennholt, Matthew Cole

Publikováno v: Environmental Science and Technology
Hartmann, N B, Hüffer, T, Thompson, R C, Hassellöv, M, Verschoor, A, Daugaard, A E, Rist, S, Karlsson, T, Brennholt, N, Cole, M, Herrling, M P, Hess, M C, Ivleva, N P, Lusher, A L & Wagner, M 2019, ' Are We Speaking the Same Language? Recommendations for a Definition and Categorization Framework for Plastic Debris ', Environmental Science & Technology, vol. 53, no. 3, pp. 1039-1047 . https://doi.org/10.1021/acs.est.8b05297

The accumulation of plastic litter in natural environments is a global issue. Concerns over potential negative impacts on the economy, wildlife, and human health provide strong incentives for improving the sustainable use of plastics. Despite the man

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37486f6bd3f7eeea16566f9bb8c7a6c8
https://pubmed.ncbi.nlm.nih.gov/30608663