Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Veronique Vreys"'
Autor:
Patrick Angibaud, Kristof van Emelen, Martin Page, Michel Janicot, Marc Du Jardin, Luc Andries, Ilse Goris, Willem Talloen, Kees Bol, Eugene Cox, Veronique Vreys, Ian Hickson, Ron Gilissen, Laurence Decrane, Bruno Roux, Isabelle Pilatte, Lut Janssen, Ann Belin, Wim Floren, Ann Marin, Peter King, Janine Arts
Purpose: Histone deacetylase (HDAC) inhibitors have shown promising clinical activity in the treatment of hematologic malignancies, but their activity in solid tumor indications has been limited. Most HDAC inhibitors in clinical development only tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2434ea75f5b9b9c5f4fbdf2a8833ab91
https://doi.org/10.1158/1078-0432.c.6517927
https://doi.org/10.1158/1078-0432.c.6517927
Autor:
Patrick Angibaud, Kristof van Emelen, Martin Page, Michel Janicot, Marc Du Jardin, Luc Andries, Ilse Goris, Willem Talloen, Kees Bol, Eugene Cox, Veronique Vreys, Ian Hickson, Ron Gilissen, Laurence Decrane, Bruno Roux, Isabelle Pilatte, Lut Janssen, Ann Belin, Wim Floren, Ann Marin, Peter King, Janine Arts
Supplementary Data from JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a60eef472554e462da36d628bd346f
https://doi.org/10.1158/1078-0432.22440625.v1
https://doi.org/10.1158/1078-0432.22440625.v1
Autor:
Janine Arts, Ann Marien, Willem Talloen, Peter King, Ian Hickson, Ron Gilissen, Kristof Van Emelen, Bruno Roux, Ilse Goris, Laurence Decrane, Wim Floren, Michel Janicot, Luc Andries, Lut Janssen, Martin John Page, Ann Beliën, Eugene Cox, Veronique Vreys, Kees Bol, Patrick Angibaud, Isabelle Noëlle Constance Pilatte, Marc Du Jardin
Publikováno v:
Clinical Cancer Research. 15:6841-6851
Purpose: Histone deacetylase (HDAC) inhibitors have shown promising clinical activity in the treatment of hematologic malignancies, but their activity in solid tumor indications has been limited. Most HDAC inhibitors in clinical development only tran
Autor:
Isere Kuiatse, Richard J. Jones, Veronique Vreys, Tarig Bashir, Alan T. Remaley, Dongmin Gu, Chad C. Bjorklund, Robert Z. Orlowski
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 346(3)
JNJ-26854165 (serdemetan) has previously been reported to inhibit the function of the E3 ligase human double minute 2, and we initially sought to characterize its activity in models of mantle cell lymphoma (MCL) and multiple myeloma (MM). Serdemetan
Autor:
Veronique Vreys, Guido David
Publikováno v:
Journal of Cellular and Molecular Medicine
Heparan sulphate proteoglycans are ubiquitous macromolecules of cell surfaces and extracellular matrices. Numerous extracellular matrix proteins, growth factors, morphogens, cytokines, chemokines and coagulation factors are bound and regulated by hep
Autor:
Christien Coomans, Zhe Zhang, Anton J.M. Roebroek, Joachim Dürr, Guido David, Nathalie Delande, Veronique Vreys
Publikováno v:
The Journal of biological chemistry. 280(39)
Mammalian heparanase, strongly implicated in the regulation of cell growth, migration, and differentiation, plays a crucial role in inflammation, angiogenesis, and metastasis. There is thus a clear need for understanding how heparanase activity is re
Autor:
Tarig Bashir, Isere Kuiatse, Dongmin Gu, Veronique Vreys, Robert Z. Orlowski, Richard J. Jones, Chad C. Bjorklund, Alan T. Remaley
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 347:540-540
Autor:
Tinne Verhulst, Janine Arts, Ann Marien, Ian Hickson, Veronique Vreys, Martin Page, Peter King, Susan A. Watson, Rajendra Kumari, M. Janssen, Patrick Angibaud, Boudewijn Janssens
Publikováno v:
Cancer Research. 70:5443-5443
We have recently reported the identification and characterization of JNJ-26481585, as a “second generation” oral pan-HDAC inhibitor. The compound has shown potent in vitro activity against solid and hematological tumor cell lines and significant