Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Veronique Parnet"'
Autor:
Craig S. Harris, Romain Pierre, Rodolphe Vatinel, Jean-Marie Arlabosse, Veronique Parnet, Catherine Raffin, Claire Bouix-Peter, Thibaud Gerfaud, Sebastien Daver, Jean-Guy Boiteau, Branislav Musicki, Guillaume Lafitte, Loïc Tomas, Gilles Ouvry
Publikováno v:
Tetrahedron. 74:5974-5986
During our research looking for novel inverse agonists of RORγt, we identified a potent sulfoximine-based modulator as one of our pre-clinical candidates for the topical treatment for psoriasis. Herein, we describe the various routes we evaluated du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15c9d3c4ef6fb9803ceb24f387ac4293
https://doi.org/10.1016/j.tet.2018.08.043
https://doi.org/10.1016/j.tet.2018.08.043
Autor:
Romain Pierre, Etienne Thoreau, Catherine Raffin, Claire Bouix-Peter, Laurent Chantalat, Gaëlle Polge, Jonathan Pascau, Gilles Ouvry, Nathalie Taquet, Catherine Comino, Denis Duvert, Danielle Orfila, Agnès Perrin, Yves Rival, Laurent Francois Andre Hennequin, Laurent Lamy, Christophe Feret, Branislav Musicki, Veronique Parnet, Anne-Pascale Luzy, Olivier Christin, Fabrice Ciesielski, Craig S. Harris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5802-5808
Targeting the IL17 pathway and more specifically the nuclear receptor RORγ is thought to be beneficial in multiple skin disorders. The Letter describes the discovery of phenoxyindazoles and thiophenoxy indazoles as potent RORγ inverse agonists. Opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af63284f22f668869fc68a5936ba38ec
https://doi.org/10.1016/j.bmcl.2016.10.023
https://doi.org/10.1016/j.bmcl.2016.10.023
Autor:
Loïc Tomas, Rodolphe Vatinel, Craig S. Harris, Veronique Parnet, Gilles Ouvry, Catherine Raffin, Bénédicte Drean, Claire Bouix-Peter, Kana Kunihiro, Guillaume Lafitte, Branislav Musicki, Jean-François Fournier, Frédéric Gaigne, Romain Pierre, Céline Bonneaud
Publikováno v:
Tetrahedron Letters. 58:3757-3759
The preparation of the boroxole motif traditionally relies on a 3-step process and the use of n -butyl lithium that can limit substrate scope. Herein during our exploration toward novel RORγ inhibitors, we identified a convenient one-pot preparation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::391ca91636278c61a11cf3907054cbb2
https://doi.org/10.1016/j.tetlet.2017.08.011
https://doi.org/10.1016/j.tetlet.2017.08.011
Autor:
Etienne Thoreau, Craig S. Harris, David Froude, Franck Bihl, Gilles Ouvry, Delphine Spiesse, Patricia Rossio, Christophe Feret, Emmanuel Vial, Laurent F. Hennequin, Jonathan Pascau, Coralie Pascau, Romain Pierre, Claire Defoin-Platel, Nathalie Taquet, Catherine Hervouet, Veronique Parnet, Olivier Christin, Guillaume Lafitte, Sophie Deret, Catherine Raffin, Claire Bouix-Peter, Anne-Pascale Luzy, Feriel Hacini-Rachinel, Branislav Musicki, Danielle Orfila, Rodolphe Vatinel
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2018, 28 (8), pp.1269-1273. ⟨10.1016/j.bmcl.2018.03.041⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2018, 28 (8), pp.1269-1273. ⟨10.1016/j.bmcl.2018.03.041⟩
Bioorganic and Medicinal Chemistry Letters, 2018, 28 (8), pp.1269-1273. ⟨10.1016/j.bmcl.2018.03.041⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2018, 28 (8), pp.1269-1273. ⟨10.1016/j.bmcl.2018.03.041⟩
Progress in the identification of suitable RORγ inverse agonists as clinical candidates has been hampered by the high lipophilicity that seems required for high potency on this nuclear receptor. In this context, we decided to focus on the replacemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fa57781e16cd4033a4b4d8d851561b
https://hal.science/hal-02526180
https://hal.science/hal-02526180
Autor:
Coralie Pascau, Nicolas Atrux-Tallau, Laurent F. Hennequin, Christophe Feret, Gilles Ouvry, Feriel Hacini-Rachinel, Craig S. Harris, Claire Defoin-Platel, Nathalie Taquet, Sophie Deret, Mathieu Forissier, Hélène Huguet, Etienne Thoreau, Benjamin Ozello, Olivier Christin, Emmanuel Vial, Guillaume Lafitte, Danielle Orfila, Isabelle Carlavan, Franck Bihl, David Froude, Jean-François Fournier, Denis Duvert, Anne-Pascale Luzy, Delphine Spiesse, Patricia Rossio, Marie-Josée Cuadrado, Jonathan Pascau, Catherine Raffin, Aline Bondu, Claire Bouix-Peter, Catherine Hervouet, Guillaume Peluchon, Veronique Parnet, David Piwnica, Branislav Musicki, Rodolphe Vatinel, Romain Pierre
Publikováno v:
ChemMedChem
ChemMedChem, 2018, 13 (4), pp.321-337. ⟨10.1002/cmdc.201700758⟩
ChemMedChem, Wiley-VCH Verlag, 2018, 13 (4), pp.321-337. ⟨10.1002/cmdc.201700758⟩
ChemMedChem, 2018, 13 (4), pp.321-337. ⟨10.1002/cmdc.201700758⟩
ChemMedChem, Wiley-VCH Verlag, 2018, 13 (4), pp.321-337. ⟨10.1002/cmdc.201700758⟩
With possible implications in multiple autoimmune diseases, the retinoic acid receptor-related orphan receptor RORγ has become a sought-after target in the pharmaceutical industry. Herein are described the efforts to identify a potent RORγ inverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad689ccdeaf5f01fb20f8a6ff41d3b4a
https://hal.science/hal-02526191
https://hal.science/hal-02526191
Autor:
Dominique Potin, Veronique Parnet, Francoise Camborde, Alix Cloarec, Joelle Meignen, Francois Caussade, Daniel Provost, Jean-Marie Teulon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:805-809
A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone(PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcade688672fc4695b0e866f5a9ef49f
https://doi.org/10.1016/s0960-894x(00)00102-5
https://doi.org/10.1016/s0960-894x(00)00102-5
Autor:
Francoise Camborde, Veronique Parnet, Alix Cloarec, Joelle Meignen, Daniel Provost, Dominique Potin, Francois Caussade, Jean-Marie Teulon
Publikováno v:
ChemInform. 31
A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone(PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc02a49dcdcb63ef25d1205556b63031
https://doi.org/10.1002/chin.200030100
https://doi.org/10.1002/chin.200030100