Effects of γ- and Hydroxypropyl-γ-cyclodextrins on the Transport of Doxorubicin across an in Vitro Model of Blood-Brain Barrier

Autor: Roméo Cecchelli, Eric Monflier, Veronique Monnaert, Laurence Fenart, Didier Betbeder, Christophe Landry, Sébastien Tilloy, Anne-Marie Lenfant, Hervé Bricout

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 311:1115-1120

Association between doxorubicin (DOX) and gamma-cyclodextrin (gamma-CD) or hydroxypropyl-gamma-CD (HP-gamma-CD) has been examined to increase the delivery of this antitumoral agent to the brain. The stoichiometry and the stability constant of gamma-C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95610760602323ff8909dd5eed0cf90e
https://doi.org/10.1124/jpet.104.071845

Behavior of α-, β-, and γ-cyclodextrins and their derivatives on an in vitro model of blood-brain barrier

Autor: Hervé Bricout, Sébastien Tilloy, Veronique Monnaert, Eric Monflier, Laurence Fenart, Roméo Cecchelli

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2004, 310 (2), p. 745-751
Journal of Pharmacology and Experimental Therapeutics, 2004, 310 (2), p. 745-751

Cyclodextrins (CDs) can be envisaged to cure some diseases related to the brain, but the behavior of these compounds toward the blood-brain barrier (BBB) remains largely unexplored to envisage such clinical applications. To fulfill this gap, the toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e581e8ef447940c1449ff196cfe10b6
https://hal-univ-artois.archives-ouvertes.fr/hal-00537883