Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Veronique Leclerc"'
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Akademický článek
Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists
Autor: Aurélie Hurtevent, Morgan Le Naour, Veronique Leclerc, Pascal Carato, Patricia Melnyk, Nathalie Hennuyer, Bart Staels, Monique Beucher-Gaudin, Daniel-Henri Caignard, Catherine Dacquet, Nicolas Lebegue
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 524-538 (2020)
A series of nitrogen heterocycles containing α–ethoxyphenylpropionic acid derivatives were designed as dual PPARα/γ agonist ligands for the treatment of type 2 diabetes (T2D) and its complications. 6-Benzoyl-benzothiazol-2-one was the most toler
Externí odkaz: https://doaj.org/article/675e141641d84b13babe4e8932ee3515
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2
Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists
Autor: Nathalie Hennuyer, Nicolas Lebegue, Morgan Le Naour, Monique Beucher-Gaudin, Daniel-Henri Caignard, Pascal Carato, Catherine Dacquet, Bart Staels, Veronique Leclerc, Patricia Melnyk, Aurelie Hurtevent
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.524-538. ⟨10.1080/14756366.2020.1713771⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2020, Journal of Enzyme Inhibition and Medicinal Chemistry, 35 (1), pp.524-538. ⟨10.1080/14756366.2020.1713771⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2020, 35 (1), pp.524-538. ⟨10.1080/14756366.2020.1713771⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 524-538 (2020)
International audience; A series of nitrogen heterocycles containing α-ethoxyphenylpropionic acid derivatives were designed as dual PPARα/γ agonist ligands for the treatment of type 2 diabetes (T2D) and its complications. 6-Benzoyl-benzothiazol-2-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe2a5c92e218360919490d45f87c2dd
https://doi.org/10.1080/14756366.2020.1713771
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3
Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression
Autor: Nathalie Hennuyer, Ghislaine Zanirato, Anne Géant, Catherine Dacquet, Daniel-Henri Caignard, Nicolas Lebegue, Bart Staels, Veronique Leclerc, Celine Pirat, Monique Beucher-Gaudin, Pascal Berthelot, Amaury Farce, Alain Ktorza
Publikováno v: European journal of medicinal chemistry. 137
A series of benzothiazol-2-one containing α-ethoxyphenylpropionic acid derivatives incorporating resveratrol or butein scaffolds were designed as fused full PPARγ agonist ligands and SIRT1-activating compounds for the treatment of type 2 diabetes (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25b194faeb144ae1043352a41573633
https://pubmed.ncbi.nlm.nih.gov/28609708
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4
Effect of Oxime Ether Incorporation in Acyl Indole Derivatives on PPAR Subtype Selectivity
Autor: Daniel-Henri Caignard, Alain Ktorza, Amaury Farce, Valérie Audinot-Bouchez, Jean-Albert Boutin, Michel Lonchampt, Nathalie Hennuyer, Catherine Dacquet, Nicolas Lebegue, Morgan Le Naour, Pascal Berthelot, Bart Staels, Veronique Leclerc
Publikováno v: ChemMedChem. 7:2179-2193
Compounds that simultaneously activate peroxisome proliferator-activated receptor (PPAR) subtypes α and γ have the potential to effectively treat dyslipidemia and type 2 diabetes (T2D) in a single pharmaceutically active molecule. The frequently ob
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e50b70924072f6e33837068ee35982
https://doi.org/10.1002/cmdc.201200316
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5
Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3
Autor: Saïd Yous, Pierre Renard, Mohamed Ettaoussi, Pascal Berthelot, Marouan Rami, Jean A. Boutin, Daniel-Henri Caignard, Veronique Leclerc, Philippe Delagrange, Amaury Farce
Publikováno v: European Journal of Medicinal Chemistry. 46:1622-1629
Naphthalenic analogs of MCA-NAT (5-methoxycarbonylamino-N-acetyltryptamine) have been synthesized and evaluated as melatonin receptor ligands. Introduction of a methoxycarbonylamino substituent at the C-7 position of the naphthalenic nucleus yields M
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14416729b4e1cb36a35023581e75cfb0
https://doi.org/10.1016/j.ejmech.2011.02.010
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6
Synthesis of Nitroindole Derivatives with High Affinity and Selectivity for Melatoninergic Binding Sites MT3
Autor: Daniel Lesieur, Veronique Leclerc, Saïd Yous, Pierre Renard, Philippe Delagrange, Jean A. Boutin
Publikováno v: Journal of Medicinal Chemistry. 45:1853-1859
The aim of this study was to synthesize selective ligands for melatoninergic subtype receptors that could elucidate the physiological role of melatonin (N-acetyl-5-methoxytryptamine, 1). So, we first investigated the role of a nitro substituent in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::469c64d485971bbde70863ddbd8a41d1
https://doi.org/10.1021/jm011053+
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7
New melatonin (MT1/MT2) ligands: design and synthesis of (8,9-dihydro-7H-furo[3,2-f]chromen-1-yl) derivatives
Autor: Saïd Yous, Elodie Landagaray, Veronique Leclerc, Pascal Berthelot, Daniel-Henri Caignard, Philippe Delagrange, Balla Traoré, Jean A. Boutin, Mohamed Ettaoussi, Olivier Nosjean, Valérie Pérez
Publikováno v: Bioorganicmedicinal chemistry. 22(3)
Herein we describe the synthesis of novel tricyclic analogues issued from the rigidification of the methoxy group of the benzofuranic analogue of melatonin as MT 1 and MT 2 ligands. Most of the synthesized compounds displayed high binding affinities
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9fffd15a8b6013d7abe5795cf83d4d
https://pubmed.ncbi.nlm.nih.gov/24417958
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9
Old and new inhibitors of quinone reductase 2
Autor: Francis Cogé, Gilles Ferry, Jean A. Boutin, Philippe Delagrange, Sylvie Berger, Veronique Leclerc, Gérald Guillaumet, Natacha Moulharat, Sabrina Hecht, Saïd Yous
Publikováno v: Chemico-biological interactions. 186(2)
Quinone reductase 2 is a cytosolic enzyme which catalyses the reduction of quinones, such as menadione and coenzymes Q. Despite a relatively close sequence-based resemblance to NAD(P)H:quinone oxidoreductase 1 (QR1), it has many different features. Q
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd33cd56036ccc2b7c91db43232feada
https://pubmed.ncbi.nlm.nih.gov/20399199
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10
Efficient Synthesis of 5- and 6-Tributylstannylindoles and Their Reactivity with Acid Chlorides in the Stille Coupling Reaction
Autor: Pascal Berthelot, Saïd Yous, Pascal Carato, Veronique Leclerc, Khalil Cherry, Nicolas Lebegue
Publikováno v: ChemInform. 38
Several 5- and 6-acylindoles have been synthesized in good yield by means of palladium catalyzed cross-coupling reactions between acid chloride derivatives and 5- or 6-tributylstannylindoles to give useful intermediates for the synthesis of analogues
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581ceac380672d006f0d7606087bc4da
https://doi.org/10.1002/chin.200748105
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