Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Veronique Damagnez"'
Autor:
Jianglin Liang, Robert J. Davies, James P. Griffith, Hardwin O'dowd, Cameron Stuver Moody, Elaine Krueger, Philip N. Collier, Yusheng Liao, Upul K. Bandarage, Alex Aronov, Jian Wang, Jingrong Cao, Derek B. Lowe, Veronique Damagnez, Elaine Y. Chin, John D. Doran, Emmanuelle Sizensky, Wojciech Dworakowski, Sudipta Mahajan, David D. Deininger, Marc Jacobs, Jinwang Xu, Arnaud Le Tiran, Suvarna Khare-Pandit, Albert C. Pierce, Suganthi Nanthakumar, Ron Grey, David Messersmith, James A. Henderson, Jon H. Come
Publikováno v:
Journal of Medicinal Chemistry. 61:5245-5256
The lipid kinase phosphoinositide 3-kinase γ (PI3Kγ) has attracted attention as a potential target to treat a variety of autoimmune disorders, including multiple sclerosis, due to its role in immune modulation and microglial activation. By minimizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd9109c79e1ecbf0788c161384fe50c
https://doi.org/10.1021/acs.jmedchem.8b00085
https://doi.org/10.1021/acs.jmedchem.8b00085
Autor:
David Messersmith, Cameron Stuver Moody, Sudipta Mahajan, Yusheng Liao, Upul K. Bandarage, Jinwang Xu, Tiansheng Wang, James P. Griffith, Arnaud Le Tiran, Veronique Damagnez, Elaine Krueger, Setu Roday, Jon H. Come, Kevin M. Cottrell, Brian Ledford, Philip N. Collier, Alex Aronov, Mark W. Ledeboer, Suvarna Khare-Pandit, John D. Doran, Christina Boucher
Publikováno v:
Journal of Medicinal Chemistry. 58:5684-5688
A series of high affinity second-generation thiazolopiperidine inhibitors of PI3Kγ were designed based on some general observations around lipid kinase structure. Optimization of the alkylimidazole group led to inhibitors with higher levels of PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a182fa6e1c15f5980023fc31188413a5
https://doi.org/10.1021/acs.jmedchem.5b00498
https://doi.org/10.1021/acs.jmedchem.5b00498
Autor:
Jennifer Qian Pan, Steven I. Dworetzky, Christopher G. Boissard, Arin Bhattacharjee, Veronique Damagnez, Yangyang Yan, Leonard K. Kaczmarek, Bo Yang, Valentin K. Gribkoff, Fred J. Sigworth
Publikováno v:
Neuropharmacology. 51:896-906
The Slack (Sequence like a calcium-activated K channel) (Slo2.2) gene is abundantly expressed in the mammalian brain and encodes a sodium-activated K+ (KNa) channel. Although the specific roles of Slack channel subunits in neurons remain to be identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2f3fb86984b4a4db5ae6a0f13322e7
https://doi.org/10.1016/j.neuropharm.2006.06.003
https://doi.org/10.1016/j.neuropharm.2006.06.003
Autor:
Kevin M. Cottrell, William Markland, Hillier Shawn M, Yuxin Wang, Pamella J. Ford, Brinley Furey, Yong Gu, Cameron Stuver Moody, Paul S. Charifson, Brenda K. Eustace, Russell R. Hoover, John Maxwell, David Newsome, Mark Wood, Reiko Arimoto, Diane M. Boucher, Veronique Damagnez, Kirk Tanner, Marina Penney
Publikováno v:
Cancer Research. 76:3716-3716
Ionizing radiation (IR), which is widely used for the treatment of cancer, causes double-strand breaks (DSBs) in DNA. If left unrepaired, these DSBs are lethal to the cell. DNA-dependent protein kinase (DNA-PK) is a key enzyme in the non-homologous e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::750ad1ce9fbbdbb30cacb5958c069005
https://doi.org/10.1158/1538-7445.am2016-3716
https://doi.org/10.1158/1538-7445.am2016-3716
Autor:
Cameron Stuver Moody, Wojciech Dworakowski, Suvarna Khare-Pandit, Sudipta Mahajan, Jon H. Come, Alex Aronov, Saurabh Saha, Arnaud LeTiran, Thomas Hoock, Linping Zhang, Michael J. Boyd, Veronique Damagnez, Joseph Prezioso, Harwin O'Dowd, Xiaoyan M. Zhang, Setu Roday
Publikováno v:
Molecular Cancer Therapeutics. 14:LB-B15
Immune checkpoint inhibitors have generated impressive clinical responses, however, a number of patients and cancer types remain resistant to checkpoint blockade. Immunosuppressive cells such as Tregs and MDSCs in the tumor microenvironment are hypot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7451030ef0c77d05119d647b5b58bfef
https://doi.org/10.1158/1535-7163.targ-15-lb-b15
https://doi.org/10.1158/1535-7163.targ-15-lb-b15
Autor:
Guillaume Cottarel, Veronique Damagnez
Publikováno v:
Gene. 172:137-141
Major transitions in the eukaryotic cell cycle are regulated by the cyclin-dependent protein kinases (CDK). In particular, the G2/M transition is initiated by the activity of a complex formed by a CDK of the Cdc2/Cdc28 family and B-type cyclins of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dca66615933d88e2f1d9b4653872f748
https://doi.org/10.1016/0378-1119(95)00893-4
https://doi.org/10.1016/0378-1119(95)00893-4
Autor:
Jeanne J. Matteo, Veronique Damagnez, Valerie E. Coleburn, Kristina Allen, Wei Chen, Ramesh A. Bhat, Frederick J. Bex, Richard J. Murrills, Peter V.N. Bodine, Bheem M. Bhat
Publikováno v:
Journal of cellular biochemistry. 108(5)
Dkk1 is a secreted antagonist of the LRP5-mediated Wnt signaling pathway that plays a pivotal role in bone biology. Because there are no well-documented LRP5-based assays of Dkk1 binding, we developed a cell-based assay of Dkk1/LRP5 binding using rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a720418a9e3ea6b57387ef005d1d6e32
https://pubmed.ncbi.nlm.nih.gov/19746449
https://pubmed.ncbi.nlm.nih.gov/19746449
Publikováno v:
Gene. 155(1)
cDNA homologues of the Saccharomyces cerevisiae UBC4 and UBC5 genes, encoding putative ubiquitin conjugating enzymes, were isolated and characterized from the fission yeast Schizosaccharomyces pombe and from the pathogenic dimorphic yeast Candida alb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec3042f8377204a07f8c28237e3637b
https://pubmed.ncbi.nlm.nih.gov/7698660
https://pubmed.ncbi.nlm.nih.gov/7698660
Autor:
Giuseppe Baldacci, Dominique Bouvier, Veronique Damagnez, Georges Pignede, Anne-Marie de Recondo, Jeanne Tillit
Publikováno v:
Experimental cell research. 198(2)
A recombinant protein was obtained in Escherichia coli by subcloning part of the Schizosaccharomyces pombe POL 1 gene at the 3′-end of lacZ . Antibodies raised against this protein were used to identify the POL 1 gene product in extracts of exponen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5852741344cd75134852bfbc1ad85ed0
https://pubmed.ncbi.nlm.nih.gov/1729129
https://pubmed.ncbi.nlm.nih.gov/1729129
Autor:
Philip N. Collier, David Messersmith, Arnaud Le Tiran, Upul K. Bandarage, Christina Boucher, Jon Come, Kevin M. Cottrell, Veronique Damagnez, John D. Doran, James P. Griffith, Suvarna Khare-Pandit, Elaine B. Krueger, Mark W. Ledeboer, Brian Ledford, Yusheng Liao, Sudipta Mahajan, Cameron S. Moody, Setu Roday, Tiansheng Wang, Jinwang Xu
Publikováno v:
Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 14, p5684-5688, 5p