Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Veronique Birault"'
Autor:
Joanna C Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I Temkin, Nathalia De Vasconcelos, Iker Valle Aramburu, Dennis Hoving, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Lena Lippert, Elisa Theresa Helbig, Florian Kurth, Bryan Williams, Aiden Flynn, Pauline T Lukey, Veronique Birault, Venizelos Papayannopoulos
Publikováno v:
eLife, Vol 12 (2024)
Background: Prinflammatory extracellular chromatin from neutrophil extracellular traps (NETs) and other cellular sources is found in COVID-19 patients and may promote pathology. We determined whether pulmonary administration of the endonuclease dorna
Externí odkaz:
https://doaj.org/article/aa0642bdfc68412890699c84f062b563
Autor:
Judith L Green, Yang Wu, Vesela Encheva, Edwin Lasonder, Adchara Prommaban, Simone Kunzelmann, Evangelos Christodoulou, Munira Grainger, Ngoc Truongvan, Sebastian Bothe, Vikram Sharma, Wei Song, Irene Pinzuti, Chairat Uthaipibull, Somdet Srichairatanakool, Veronique Birault, Gordon Langsley, Hermann Schindelin, Benjamin Stieglitz, Ambrosius P Snijders, Anthony A Holder
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008640 (2020)
Ubiquitylation is a common post translational modification of eukaryotic proteins and in the human malaria parasite, Plasmodium falciparum (Pf) overall ubiquitylation increases in the transition from intracellular schizont to extracellular merozoite
Externí odkaz:
https://doaj.org/article/02cebcacd3f549579a7e6b82f7f59588
Autor:
Susan H Smith, Carlos E Peredo, Yukimasa Takeda, Thi Bui, Jessica Neil, David Rickard, Elizabeth Millerman, Jean-Philippe Therrien, Edwige Nicodeme, Jean-Marie Brusq, Veronique Birault, Fabrice Viviani, Hans Hofland, Anton M Jetten, Javier Cote-Sierra
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147979 (2016)
Psoriasis is a chronic inflammatory skin disorder involving marked immunological changes. IL-17-targeting biologics have been successful in reducing the disease burden of psoriasis patients with moderate-to-severe disease. Unfortunately, the stratum
Externí odkaz:
https://doaj.org/article/eafec2826fc340719a00dd38c007ee18
Autor:
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I. Temkin, Nathalia De Vasconcelos, Iker Valle Aramburu, Dennis Hoving, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Bryan Williams, Aiden Flynn, Pauline T Lukey, Veronique Birault, Venizelos Papayannopoulos
BackgroundSARS-CoV2 infection causes severe, life-threatening pneumonia. Hyper-inflammation, coagulopathy and lymphopenia are associated with pathology and poor outcomes in these patients. Cell-free (cf) DNA is prominent in COVID-19 patients, amplifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86dfe7d4ab8b1c52fd3a97d5be18ddbe
https://doi.org/10.1101/2022.04.14.22272888
https://doi.org/10.1101/2022.04.14.22272888
Autor:
Jaideep Dhariwal, Aoife Cameron, Ernie Wong, Malte Paulsen, Maria-Belen Trujillo-Torralbo, Ajerico del Rosario, Eteri Bakhsoliani, Tatiana Kebadze, Mark Almond, Hugo Farne, Leila Gogsadze, Julia Aniscenko, Batika M. J. Rana, Trevor T. Hansel, David J. Jackson, Onn Min Kon, Michael R. Edwards, Roberto Solari, David J. Cousins, Ross P. Walton, Sebastian L. Johnston, Paul Lavender, Hannah Gould, David Cousins, Antoon J. van Oosterhout, Nathan W. Bartlett, Patrick Mallia, Jerico del Rosario, Janet L. Smith, Matthew J. Edwards, Karen Affleck, Nil Turan Jurdzinski, Veronique Birault, Peter McErlean, Yu-Chang Wu, Nadine Upton, Ismael Ranz Jimenez
Publikováno v:
Am J Respir Crit Care Med
RATIONALE: Type 2 innate lymphoid cells (ILC2s) are significant sources of type 2 cytokines, which are implicated in the pathogenesis of asthma and asthma exacerbations. The role of ILC2s in virus-induced asthma exacerbations is not well characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816761f5244c7709ec80777271040f45
https://europepmc.org/articles/PMC8786078/
https://europepmc.org/articles/PMC8786078/
Autor:
Irene Pinzuti, Chairat Uthaipibull, Somdet Srichairatanakool, Judith L. Green, Sebastian Bothe, Yang Wu, Ambrosius P. Snijders, Edwin Lasonder, Evangelos Christodoulou, Simone Kunzelmann, Hermann Schindelin, Vikram Sharma, Adchara Prommaban, Vesela Encheva, Veronique Birault, Munira Grainger, Ngoc Truongvan, Anthony A. Holder, Benjamin Stieglitz, Gordon Langsley, Wei Song
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008640 (2020)
PLoS Pathogens
PLoS Pathogens
Ubiquitylation is a common post translational modification of eukaryotic proteins and in the human malaria parasite, Plasmodium falciparum (Pf) overall ubiquitylation increases in the transition from intracellular schizont to extracellular merozoite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be30eb33ff47d47910ec80ee8b794971
https://nrl.northumbria.ac.uk/id/eprint/43579/9/journal.ppat.1008640.pdf
https://nrl.northumbria.ac.uk/id/eprint/43579/9/journal.ppat.1008640.pdf
Publikováno v:
Nucleic Acids Research
In this study, we demonstrate that the lack of retinoic acid-related orphan receptor (ROR) γ or α expression in mice significantly reduced the peak expression level of Cry1, Bmal1, E4bp4, Rev-Erbα and Per2 in an ROR isotype- and tissue-selective m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f20f70a969b5a505a06ce229781fdd4
https://doi.org/10.1093/nar/gks630
https://doi.org/10.1093/nar/gks630
Autor:
Graeme W. Carlile, Qi Yang, Elizabeth Matthes, Jie Liao, Véronique Birault, Helen F. Sneddon, Darren L. Poole, Callum J. Hall, John W. Hanrahan, David Y. Thomas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER). Partial rescue of the
Externí odkaz:
https://doaj.org/article/6c974b2051ad451a915f788a93fa1833
Publikováno v:
Helvetica Chimica Acta. 86:2210-2227
The spirodiaziridines 6 and 9, potential inhibitors of α- and β-glucosidases, were prepared from the validoxylamine A-derived cyclohexanone 5. The trimethylsilyl protecting groups of 5 are crucial for the formation of 6 in good yields. Oxidation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ed9ee065303ad01e0b3ebebb6f0285
https://doi.org/10.1002/hlca.200390178
https://doi.org/10.1002/hlca.200390178
Autor:
Kim Louise Hirst, Andrew Self, John Richard Harris, Giovanni Tricarico, J. Andrew Clase, Vivienne Allen, Graham Dixon, Martin James Inglis Andrews, Wolfgang Schmidt, Kevin M. Nash, Veronique Birault, Reginald Brys, Joelle Le, Paul John Edwards, Mark Stuart Chambers, Angus Murray Macleod, Gregory Bar
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(6)
MAPKAPK5 has been proposed to play a role in regulation of matrix metalloprotease expression and so to be a potential target for intervention in rheumatoid arthritis. We present here the identification of a series of compounds against this target whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e2b04350fa60c0e075bba3bf5194d2
https://pubmed.ncbi.nlm.nih.gov/22342143
https://pubmed.ncbi.nlm.nih.gov/22342143