Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury

Autor: Veronique Beneton, Veena Supramaniam, Bobbi Fleiss, Juliette Van Steenwinckel, Ana A. Baburamani, Carina Mallard, Leslie Schwendimann, Jingjun Li, Nathalie Journiac, Pierrette Young-Ten, Boris Matrot, Pierre Gressens, Johanna Maze, A. David Edwards, Claire-Marie Rangon, Sophie Lebon, Henrik Hagberg, Libo Chen, Tingting Fu, Thomas Bourgeois, Tsu Tshen Chuang, Lionel Trottet, Anne-Laure Schang

Publikováno v: Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, 2018, 74, pp.265-276. ⟨10.1016/j.bbi.2018.09.017⟩
Brain, Behavior, and Immunity, Elsevier, 2018, 74, pp.265-276. ⟨10.1016/j.bbi.2018.09.017⟩
Rangon, C-M, Schang, A-L, Van Steenwinckel, J, Schwendimann, L, Lebon, S, Fu, T, Chen, L, Beneton, V, Journiac, N, Young-Ten, P, Bourgeois, T, Maze, J, Matrot, B, Baburamani, A A, Supramaniam, V, Mallard, C, Trottet, L, Edwards, A D, Hagberg, H, Fleiss, B, Li, J, Tshen Chuang, T & Gressens, P 2018, ' Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury ', Brain, Behavior, and Immunity . https://doi.org/10.1016/j.bbi.2018.09.017

Fifteen million babies are born preterm every year and a significant number suffer from permanent neurological injuries linked to white matter injury (WMI). A chief cause of preterm birth itself and predictor of the severity of WMI is exposure to mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa546a18578e42184049bd5d01ae655
https://doi.org/10.1016/j.bbi.2018.09.017

Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists

Autor: Julien Sançon, Veronique Beneton, Paul Martres, Edwige Nicodeme, Nicolas Ancellin, Nicolas Faucher, Jean-Jacques Tousaint, Yannick Saintillan, Yann Lamotte, Stéphane Sautet, Didier Grillot, Marie-Hélène Fouchet, Olivier Pineau

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:1098-1103

Identification of indazole derivatives acting as dual angiotensin II type 1 (AT1) receptor antagonists and partial peroxisome proliferator-activated receptor-γ (PPARγ) agonists is described. Starting from Telmisartan, we previously described that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7734bd05776715f9fce40d12fc7a62
https://doi.org/10.1016/j.bmcl.2014.01.004

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

Autor: Matthew G.F. Sharp, Paul Rowland, Benjamin Beaufils, Kris Wilson, Martin Wilkinson, John P. Iredale, Christopher G. Mowat, Margaret Binnie, Ann Louise Walker, O. James Garden, Veronique Beneton, Jonathan P. Hutchinson, Andrew McBride, Natalie Z.M. Homer, James Baily, Jeremy Hughes, Lionel Trottet, John Liddle, Nicolas Ancellin, Olivier Mirguet, Xiaozhong Zheng, Damian J. Mole, Scott P. Webster, Iain Uings, Sarah E. M. Howie, Duncan S. Holmes, Carl Haslam

Publikováno v: Mole, D J, Webster, S P, Uings, I, Zheng, X, Binnie, M, Wilson, K, Hutchinson, J P, Mirguet, O, Walker, A, Beaufils, B, Ancellin, N, Trottet, L, Bénéton, V, Mowat, C G, Wilkinson, M, Rowland, P, Haslam, C, McBride, A, Homer, N Z M, Baily, J E, Sharp, M G F, Garden, O J, Hughes, J, Howie, S E M, Holmes, D S, Liddle, J & Iredale, J P 2016, ' Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis ', Nature Medicine, vol. 22, no. 2, pp. 202-209 . https://doi.org/10.1038/nm.4020
Mole, D J, Webster, S P, Uings, I, Zheng, X, Binnie, M, Wilson, K, Hutchinson, J P, Mirguet, O, Walker, A, Beaufils, B, Ancellin, N, Trottet, L, Bénéton, V, Mowat, C G, Wilkinson, M, Rowland, P, Haslam, C, McBride, A, Homer, N Z M, Baily, J E, Sharp, M G F, Garden, O J, Hughes, J, Howie, S E M, Holmes, D S, Liddle, J & Iredale, J P 2016, ' Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis ', Nature Medicine, vol. 22, no. 2, pp. 202-209 . https://doi.org/10.1038/nm.4020
Nature medicine

Acute pancreatitis (AP) is a common and devastating inflammatory condition of the pancreas that is considered to be a paradigm of sterile inflammation leading to systemic multiple organ dysfunction syndrome (MODS) and death1,2. Acute mortality from A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff8f32000cb509021d48ffa9419a9b1
https://pubmed.ncbi.nlm.nih.gov/26790366

The discovery of equipotent PPARalpha/gamma dual activators

Autor: Paul, Martres, Nicolas, Faucher, Alain, Laroze, Olivier, Pineau, Marie Helene, Fouchet, Florent, Potvain, Didier, Grillot, Veronique, Beneton

Publikováno v: Bioorganicmedicinal chemistry letters. 18(23)

We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f50c2b7c9dac00c370b4e32cb722496d
https://pubmed.ncbi.nlm.nih.gov/18947994