Výsledky vyhledávání - "Veronika Sherwood"

Tyrosine Kinase Inhibitors. 18. 6-Substituted 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Soluble, Irreversible Inhibitors of the Epidermal Growth Factor Receptor

Autor: David W. Fry, William L. Elliott, Patrick W. Vincent, Dennis J. McNamara, Jeff B. Smaill, William A. Denny, Zhou Hairong, James M. Nelson, H. D. Hollis Showalter, Veronika Sherwood, Bill J. Roberts, Alexander James Bridges

Publikováno v: Journal of Medicinal Chemistry. 44:429-440

4-Anilinoquinazoline- and 4-anilinopyrido[3,4-d]pyrimidine-6-acrylamides are potent pan-erbB tyrosine kinase inactivators, and one example (CI-1033) is in clinical trial. A series of analogues with a variety of Michael acceptor units at the 6-positio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d10c67de11114be6a17fc2c444dea44
https://doi.org/10.1021/jm000372i

Zobrazit plný text záznamu

Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts

Autor: William L. Elliott, Steven E. Rose, Patrick W. Vincent, Sandra J. Patmore, Veronika Sherwood, David W. Fry, Hairong Zhou, Wilber R. Leopold, Billy J. Roberts, Alex J. Bridges, Donald J. Dykes

Publikováno v: Cancer Chemotherapy and Pharmacology. 45:231-238

Purpose: The involvement of the EGF receptor (EGFr) family of receptors in cancers suggests that a selective inhibitor of the tyrosine kinase activity of the EGFr family could have a therapeutic effect. PD 0169414, an anilinoquinazoline, is a potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4c1a143aba1d579ec730162381469f
https://doi.org/10.1007/s002800050034

Zobrazit plný text záznamu

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

Autor: Ellen Myra Dobrusin, James M. Nelson, Kenneth E. Hook, Alexander James Bridges, Dennis Joseph Mcnamara, David W. Fry, Susanne Trumpp-Kallmeyer, Joseph A. Loo, Veronika Sherwood, Wilbur R. Leopold, James L. Hicks, Paul R. Keller, Kenneth D. Greis, William A. Denny, Annette Marian Doherty, Jeff B. Smaill

Publikováno v: Proceedings of the National Academy of Sciences. 95:12022-12027

A class of high-affinity inhibitors is disclosed that selectively target and irreversibly inactivate the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a cysteine residue present in the ATP binding pocket.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea16a2a86b4700b22a20c567f23b248
https://doi.org/10.1073/pnas.95.20.12022

Zobrazit plný text záznamu

Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions

Autor: Jeff B. Smaill, Gordon W. Rewcastle, Alexander J. Bridges, Hairong Zhou, H. D. Hollis Showalter, David W. Fry, James M. Nelson, Veronika Sherwood, William L. Elliott, Patrick W. Vincent, Dana E. DeJohn, Joseph A. Loo, Kenneth D. Greis, O. Helen Chan, Eric L. Reyner, Elke Lipka, William A. Denny

Publikováno v: Journal of Medicinal Chemistry. 43:3199-3199

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f21b6eb46c45d0e1b6ff1a310d4f69cc
https://doi.org/10.1021/jm000250q

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání