Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Veronika Sačková"'
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 12, Pp 8388-8405 (2011)
Several photodynamically-active substances and farnesyltransferase inhibitors are currently being investigated as promising anticancer drugs. In this study, the combined effect of hypericin (the photodynamically-active pigment from Hypericum perforat
Externí odkaz:
https://doaj.org/article/2c2c644362a648b1a1d991b7aaedd10e
Publikováno v:
Anti-Cancer Drugs. 29:983-994
Cancer cells disseminate to other parts of the body during metastasis through the process of intravasation. The hypericin and hyperforin effect has been described to understand the signal mechanisms that stimulate or stunt cancer cell sprouting to me
Autor:
Mária Macejová, Vlasta Demeckova, Rastislav Jendželovský, Veronika Sačková, Peter Fedoročko, Petra Hradicka
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 66
The use of natural products as chemotherapeutic agents and tools for manipulation of apoptosis represent an attractive therapeutic concept. In this study, we investigated the anticancer activities of a combination of two natural compounds with differ
Autor:
Mangesh Bhide, Patrícia Kimáková, Martina Šemeláková, Veronika Sačková, Lenka Ilkovičová, Peter Solár, Barbora Fecková, Erika Szentpéteriová, Nataša Debeljak, Zuzana Solárová
Publikováno v:
Oncology Letters. 12:1575-1580
The erythropoietin receptor (EpoR) is a member of the cytokine receptor family. The interaction between erythropoietin (Epo) and EpoR is important for the production and maturation of erythroid cells, resulting in the stimulation of hematopoiesis. Th
Autor:
Peter Solár, Barbora Fecková, Veronika Sačková, Lenka Ilkovičová, Zuzana Solárová, Martin Kello, Patrícia Kimáková
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 85
Photoactivated hypericin increased production of reactive oxygen species in human breast adenocarcinoma MCF-7 as well as in MDA-MB-231 cells 1h after photodynamic therapy. On the other hand, reactive oxygen species dropped 3h after photodynamic thera
Autor:
Veronika Sačková, Rastislav Jendželovský, Soňa Gancarčíková, Vlasta Demeckova, Bojková B, Peter Fedoročko, Gabriela Hrčková, Monika Kassayová, Dagmar Mudroňová, Peter Solár
Publikováno v:
Oncology reports. 37(1)
Manumycin A is a natural antibiotic isolated from Streptomyces parvulus with broad range of biological activities including antineoplastic activity in several in vitro and in vivo cancer models. Immodin [dialyzable leukocyte extract (DLE)] is a dialy
Autor:
Jaromír Mikeš, Rastislav Jendželovský, Peter Fedoročko, Jiřina Procházková, Ján Koval, Karel Souček, Jiřina Hofmanová, Veronika Sačková, Alois Kozubík, Martin Kello
Publikováno v:
Photochemical & Photobiological Sciences. 8:1716-1723
Photodynamic therapy (PDT) is a flexible multi-target therapeutic approach. One of the main requirements of successful PDT is sufficient intracellular concentration of an applicable photosensitizer. Mechanisms of anticancer drug elimination by tumour
Autor:
Peter Fedoročko, Viktor Horváth, Jiřina Hofmanová, Ján Kleban, Jaromír Mikeš, Alois Kozubík, Veronika Sačková
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 93:108-118
In our previous study we have proved that colon cancer cells HT-29 pre-treated with specific 5-lipoxygenase inhibitor MK-886 became more susceptible to photodynamic therapy (PDT) with hypericin and we also found that this mutual combination induced c
Autor:
Jaromír Mikeš, Jiřina Hofmanová, Brezáni P, Veronika Sačková, Ján Kleban, Peter Fedoročko, Viktor Horváth, Alois Kozubík, Beáta Szilárdiová
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 84:79-88
It may be hypothesized that the lipoxygenase (LOX) metabolic pathway plays an important role in photodynamic therapy (PDT) of malignant tumours, and modification of this pathway may result in administration of lower doses of photodynamic active agent
Autor:
Martin Kello, Ivana Uhrinová, Lucia Kuliková, Jaromír Mikeš, Veronika Sačková, Ján Koval, Rastislav Jendželovský, Peter Fedoročko
Publikováno v:
Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 8(11)
Photodynamic therapy with hypericin (HY-PDT) is known as an efficient modality for treatment of various cancerous and non-cancerous diseases. Although the role of p53 protein in cell death signaling is well established, relatively little is known of