Výsledky vyhledávání - "Veronika Rozehnal"

Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models

Autor: Veronika Rozehnal, Tomoko Ishizuka, Daisuke Sugiyama, Makiko Yamada, Thomas Fischer, Shin-ichi Inoue

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 48(9)

Esaxerenone (CS-3150) is a novel, oral, nonsteroidal, selective mineralocorticoid receptor blocker approved for the treatment of hypertension in Japan. Here, the drug-drug interaction (DDI) potential of esaxerenone was evaluated in vitro, and its imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7ee17672922b3ae3b1079c2aac82bb
https://pubmed.ncbi.nlm.nih.gov/32616542

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In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

Autor: Veronika Rozehnal, Ilona Schreck, Osamu Ando, Tsuneo Deguchi, Chie Makino, Hiroshi Yamazaki, Nobuaki Watanabe, Hideyuki Shiozawa, Akiko Watanabe, Tomoko Ishizuka, Norie Murayama

A 1,2,4-oxadiazole ring-containing compound DS-8500a was developed as a novel G protein-coupled receptor 119 agonist. In vivo metabolic fates of [14C]DS-8500a differently radiolabeled in the benzene ring or benzamide side carbon in rats were investig

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Interindividual Variability of Carboxymethylenebutenolidase Homolog, a Novel Olmesartan Medoxomil Hydrolase, in the Human Liver and Intestine

Autor: Takashi Izumi, Tomoko Ishizuka, Seiko Endo, Ayako Kato, Veronika Rozehnal, Atsushi Kurihara, Yasushi Yoshigae, Thomas Fischer

Publikováno v: Drug Metabolism and Disposition. 41:1156-1162

Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor antagonist. OM is rapidly converted into its active metabolite olmesartan by multiple hydrolases in humans, and we recently identified carboxymethylenebutenolidase homolog (CM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1239d703c5971c4a7c1d8f1a06c0d93
https://doi.org/10.1124/dmd.113.051482

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Human small intestinal and colonic tissue mounted in the Ussing chamber as a tool for characterizing the intestinal absorption of drugs

Autor: Veronika Rozehnal, Ursula Hoepner, Juergen Mueller, Daisuke Nakai, Emi Kamiyama, Satoru Yasuda, Thomas Fischer, Masayuki Takahashi

Publikováno v: European Journal of Pharmaceutical Sciences. 46:367-373

The purpose of this study was to validate human small intestinal and colonic tissue mounted in the Ussing chamber as a tool for predicting the oral drug absorption in humans with the main focus on moderately and poorly permeable compounds. The obtain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bb39ba7e8fe140670dd1bc99328763
https://doi.org/10.1016/j.ejps.2012.02.025

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Commonly used nonionic surfactants interact differently with the human efflux transporters ABCB1 (p-glycoprotein) and ABCC2 (MRP2)

Autor: Veronika Rozehnal, Werner Siegmund, K. May, Ulrike Hanke, Werner Weitschies, Stefan Nagel

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 76:260-268

The efflux transporters ABCB1 (p-glycoprotein) and ABCC2 (MRP2) play an essential role in the limitation of oral bioavailability of drugs. In the last years, pharmaceutical surfactants like cremophor® EL or polysorbate 80 have been shown to interact

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https://doi.org/10.1016/j.ejpb.2010.06.008

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Edoxaban transport via P-glycoprotein is a key factor for the drug's disposition

Autor: Takashi Izumi, Thomas Fischer, Yasushi Yoshigae, Tsuyoshi Mikkaichi, Hiroshi Masumoto, Tomoki Imaoka, Veronika Rozehnal, Noriko Okudaira

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 42(4)

Edoxaban (the free base of DU-176b), an oral direct factor Xa inhibitor, is mainly excreted unchanged into urine and feces. Because active membrane transport processes such as active renal secretion, biliary excretion, and/or intestinal secretion, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6be3b9ee2ad76caeb7e7cb441befb3
https://pubmed.ncbi.nlm.nih.gov/24459178

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Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines

Autor: Petr Pavek, Veronika Rozehnal, Katerina Pospechova, Gabriela Jamborova, Zdenek Dvorak, Nada Pospisilova, Petr Nachtigal, Vladimir Semecky, Werner Siegmund, K. May, Lucie Stejskalova, Radim Vrzal

Publikováno v: Molecular and cellular endocrinology. 299(2)

Vitamin D receptor (VDR) regulates the expression of many genes involved in mineral metabolism, cellular proliferation, differentiation and drug biotransformation. We studied the expression and activity of VDR and its heterodimerization partner retin

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https://pubmed.ncbi.nlm.nih.gov/19133314

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