Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Veronika Racakova"'
Autor:
David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE
Externí odkaz:
https://doaj.org/article/4eaa3b83e7db43c89b59bdfb119cb77b
Autor:
Daniel Jun, Eva Mezeiova, Rudolf Andrys, Jan Korabecny, Lukas Gorecki, Kamil Musilek, David Malinak, Miroslava Hozova, Veronika Racakova, Petr Bzonek, Kamil Kuca, Miroslav Psotka, Vendula Hepnarova, Rafael Dolezal
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE
Autor:
Jiri Krenek, Jan Trejbal, Veronika Racakova, Karel Kolar, Natálie Karásková, Michaela Melikova, Nadezhda V. Maltsevskaya, Rafael Dolezal, Kamil Kuca
Publikováno v:
Computational Collective Intelligence ISBN: 9783319670768
ICCCI (2)
ICCCI (2)
Successful development of novel drugs requires a close cooperation of experimental subjects, such as chemistry and biology, with theoretical disciplines in order to confidently design new chemical structures eliciting the desired therapeutic effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87817d6c64e17aff2a4c7a03cdf430ff
https://doi.org/10.1007/978-3-319-67077-5_17
https://doi.org/10.1007/978-3-319-67077-5_17
Publikováno v:
Computational Collective Intelligence ISBN: 9783319452456
ICCCI (2)
ICCCI (2)
Undoubtedly, computer aided drug design (CADD) has gained important position in medicinal chemistry thanks to balancing random approaches to discovery of new drugs by prioritizing rational insight into the development process. From many CADD methods,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8fadf90eaeeac913bb315574e8873cc
https://doi.org/10.1007/978-3-319-45246-3_26
https://doi.org/10.1007/978-3-319-45246-3_26
Structure-Activity Relationship of Acetylcholinesterase Reactivators -Antidotes Against Nerve Agents
Publikováno v:
Letters in Organic Chemistry. 4:212-217
Autor:
Martina Husáková, Veronika Racakova, Richard Cimler, Jan Korabecny, Agáta Bodnárová, Kamil Kuca, Lukas Najman, Ondrej Krejcar, Rafael Dolezal, Jiri Krenek
Publikováno v:
Progress in Artificial Intelligence ISBN: 9783319234847
EPIA
EPIA
In the last several decades, the drug research has moved to involve various IT technologies in order to rationalize the design of novel bioactive chemical compounds. An important role among these computer-aided drug design (CADD) methods is played by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7e0eb341961dd3b7e415c82d2116c37
https://doi.org/10.1007/978-3-319-23485-4_33
https://doi.org/10.1007/978-3-319-23485-4_33
Publikováno v:
Journal of Applied Biomedicine. 4:147-151
Organophosphorus pesticides such as parathion or chlorpyrifos are substances used worldwide for agricultural purposes. These compounds are able to inhibit an enzyme acetylcholinesterase (AChE; EC 3.1.1.7) by phosphorylation in its active site. AChE r
Publikováno v:
Arhiv za higijenu rada i toksikologiju. 57(4)
This paper describes an in vitro study of three potential acetylcholinesterase (AChE; EC 3.1.1.7) reactivators derived from a monoquaternary reactivator pralidoxime. Compounds used were pyridinium-2-aldoxime-4-carbamoyl-N-methyl iodide (TO231), pyrid
Publikováno v:
Chemical Papers. 61
Organophosphorus pesticides parathion, chlorpyrifos, and malathion inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7) via phosphorylation of its active site. AChE reactivators and anticholinergics are compounds used as antidotes in the case o
Autor:
Kamil Musilek, Martin Doležal, L. Lipka, Daniel Jun, Vlastimil Dohnal, Kamil Kuca, Veronika Racakova
Publikováno v:
Scopus-Elsevier
Nine potential AChE reactivators were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the previous results, 1,4-bis(2-hydroxy