Sweet taste of heavy water

Autor: Natalie Ben Abu, Philip E. Mason, Hadar Klein, Nitzan Dubovski, Yaron Ben Shoshan-Galeczki, Einav Malach, Veronika Pražienková, Lenka Maletínská, Carmelo Tempra, Victor Cruces Chamorro, Josef Cvačka, Maik Behrens, Masha Y. Niv, Pavel Jungwirth

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)

Ben Abu, Mason and colleagues use molecular dynamics, cell-based experiments, mouse models, and human subjects to determine that, unlike ordinary water, heavy water tastes sweet to humans, but not mice. Mechanistically, this effect is mediated by the

Externí odkaz: https://doaj.org/article/59c790f203ca458d882dcdb0ab0241f8

Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons

Autor: Jaroslav Kuneš, Marie-Christine Galas, Claire Schirmer, Blanka Železná, Veronika Pražienková, Lenka Maletínská, Martina Holubová

Publikováno v: Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, 2019, 67 (4), pp.1187-1200. ⟨10.3233/JAD-180837⟩
Journal of Alzheimer's Disease, IOS Press, 2019, 67 (4), pp.1187-1200. ⟨10.3233/JAD-180837⟩

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by the accumulation of extracellular amyloid plaques and intraneuronal neurofibrillary tangles. These tangles mainly consist of hyperphosphorylated tau pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c9b809bcba14bace2cf6eb09494087
https://doi.org/10.3233/jad-180837

Mass spectrometry imaging of free-floating brain sections detects pathological lipid distribution in a mouse model of Alzheimer's-like pathology

Autor: Josef Cvačka, Veronika Pražienková, Vladimír Vrkoslav, David Sýkora, Lenka Maletínská, Jaroslav Kuneš, Martina Holubová, Blanka Železná, Štěpán Strnad

Publikováno v: The Analyst. 145(13)

Mass spectrometry imaging (MSI) is a modern analytical technique capable of monitoring the spatial distribution of compounds within target tissues. Collection and storage are important steps in sample preparation. The recommended and most widely used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a427b52a07e0ad4d6f89590efddb8b8
https://pubmed.ncbi.nlm.nih.gov/32436545

Synergistic effect of leptin and lipidized PrRP on metabolic pathways in ob/ob mice

Autor: Veronika Pražienková, Lucie Hrubá, Martina Holubová, Martin Haluzik, Barbora Neprašová, Blanka Železná, Michal Bencze, Jaroslav Kuneš, Lenka Maletínská, Lucia Kořínková

Publikováno v: Journal of molecular endocrinology. 64(2)

Lack of leptin production in ob/ob mice results in obesity and prediabetes that could be partly reversed by leptin supplementation. In the hypothalamus, leptin supports the production of prolactin-releasing peptide (PrRP), an anorexigenic neuropeptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9cf3ad088ef3a0ae2513d15ed8573b
https://pubmed.ncbi.nlm.nih.gov/31855558

Prolactin-Releasing Peptide: Physiological and Pharmacological Properties

Autor: Veronika Pražienková, Lenka Maletínská, Jaroslav Kuneš, Andrea Popelová

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 21, p 5297 (2019)
International Journal of Molecular Sciences

Prolactin-releasing peptide (PrRP) belongs to the large RF-amide neuropeptide family with a conserved Arg-Phe-amide motif at the C-terminus. PrRP plays a main role in the regulation of food intake and energy expenditure. This review focuses not only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31582e51a17c42c54b0c74850287622
https://www.mdpi.com/1422-0067/20/21/5297