Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Veronika Obsilova"'
Publikováno v:
eLife, Vol 13 (2024)
Apoptosis signal-regulating kinase 1 (ASK1) is a crucial stress sensor, directing cells toward apoptosis, differentiation, and senescence via the p38 and JNK signaling pathways. ASK1 dysregulation has been associated with cancer and inflammatory, car
Externí odkaz:
https://doaj.org/article/fbfd17cff81c4de6912edeec406e7563
Autor:
Veronika Obsilova, Tomas Obsil
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Cell signaling regulates several physiological processes by receiving, processing, and transmitting signals between the extracellular and intracellular environments. In signal transduction, phosphorylation is a crucial effector as the most common pos
Externí odkaz:
https://doaj.org/article/4a16b6ac4b1b4d95b5f6c000f6440684
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Horvath et al. structurally and biochemically characterize the full-length human DAPK2-14-3-3 complex to investigate the effects of binding to DAPK2 on its dimerization, activation by dephosphorylation of Ser318, and Ca2+/calmodulin binding. Their re
Externí odkaz:
https://doaj.org/article/b760ecb751c143968c2d8af2223e83c8
Autor:
Veronika Obsilova, Tomas Obsil
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Signal transduction cascades efficiently transmit chemical and/or physical signals from the extracellular environment to intracellular compartments, thereby eliciting an appropriate cellular response. Most often, these signaling processes are mediate
Externí odkaz:
https://doaj.org/article/a5c0432fcfb24598a3bac6e9734c118d
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Pohl et al. investigated the structural basis of Nedd4-2 regulation by 14-3-3 and found that phosphorylated Ser342 and Ser448 are the main residues that facilitate 14-3-3 binding to Nedd4-2. The authors propose that the Nedd4-2:14-3-3 complex then st
Externí odkaz:
https://doaj.org/article/28f3af453a79406099b6b0c5ec6e9945
Autor:
Judith Hagenbuchner, Veronika Obsilova, Teresa Kaserer, Nora Kaiser, Bettina Rass, Katarina Psenakova, Vojtech Docekal, Miroslava Alblova, Klara Kohoutova, Daniela Schuster, Tatsiana Aneichyk, Jan Vesely, Petra Obexer, Tomas Obsil, Michael J Ausserlechner
Publikováno v:
eLife, Vol 8 (2019)
FOXO transcription factors are critical regulators of cell homeostasis and steer cell death, differentiation and longevity in mammalian cells. By combined pharmacophore-modeling-based in silico and fluorescence polarization-based screening we identif
Externí odkaz:
https://doaj.org/article/2a1679493eee41128e3edfeaf260a091
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13395 (2021)
Apoptosis signal-regulating kinase (ASK) 1, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, modulates diverse responses to oxidative and endoplasmic reticulum (ER) stress and calcium influx. As a crucial cellular stress
Externí odkaz:
https://doaj.org/article/e190d9d55c5647beafae3a31b7274661
Autor:
Veronika Obsilova, Tomas Obsil
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8824 (2020)
Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for norma
Externí odkaz:
https://doaj.org/article/0d75edde0b9e458288c605fc9d4ea25f
Autor:
Katarina Psenakova, Klara Kohoutova, Veronika Obsilova, Michael J. Ausserlechner, Vaclav Veverka, Tomas Obsil
Publikováno v:
Cells, Vol 8, Iss 9, p 966 (2019)
FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition may have beneficial effects on d
Externí odkaz:
https://doaj.org/article/5535b5d8c825421d95d204de33775efd
Autor:
Klara Kohoutova, Vojtěch Dočekal, Michael J. Ausserlechner, Nora Kaiser, Andrej Tekel, Raju Mandal, Matej Horvath, Veronika Obsilova, Jan Vesely, Judith Hagenbuchner, Tomas Obsil
Publikováno v:
ACS Omega. 7:34632-34646
Increased FOXO3 nuclear localization is involved in neuroblastoma chemoresistance and tumor angiogenesis. Accordingly, FOXO3 inhibition is a promising strategy for boosting antitumor immune responses and suppressing FOXO3-mediated therapy resistance