Asc-1 transporter regulation of synaptic activity via the tonic release of D-serine in the forebrain

Autor: Hazem Safory, Eitan Kaplan, Jean-Marie Billard, Christoffer Bundgaard, Christian Thomsen, Avi Avital, Hagit Sason, Salman Zubedat, Samah Neame, Kenneth Vielsted Christensen, Dina Rosenberg, Claus Tornby Christoffersen, Garrick Paul Smith, Herman Wolosker, Veronika N. Foltyn

Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2017, 27 (2), pp.1573-1587. ⟨10.1093/cercor/bhv350⟩
Cerebral Cortex, Oxford University Press (OUP), 2017, 27, pp.1573-1587. ⟨10.1177/0271678X15626718⟩

d-Serine is a co-agonist of NMDA receptors (NMDARs) whose activity is potentially regulated by Asc-1 (SLC7A10), a transporter that displays high affinity for d-serine and glycine. Asc-1 operates as a facilitative transporter and as an antiporter, tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e811a43353d2e0dd0cbd67c9faf985c
https://hal-normandie-univ.archives-ouvertes.fr/hal-02325027

d-Amino acids in the brain: d-serine in neurotransmission and neurodegeneration

Autor: Elena Dumin, Veronika N. Foltyn, Livia Balan, Herman Wolosker

Publikováno v: FEBS Journal. 275:3514-3526

The mammalian brain contains unusually high levels of D-serine, a D-amino acid previously thought to be restricted to some bacteria and insects. In the last few years, studies from several groups have demonstrated that D-serine is a physiological co-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23b39f85d3347665a28ed49058ae8690
https://doi.org/10.1111/j.1742-4658.2008.06515.x

Serine Racemase Modulates Intracellular D-Serine Levels through an α,β-Elimination Activity

Autor: Joari De Miranda, Herman Wolosker, Veronika N. Foltyn, Michael D. Toney, Inna Bendikov, Elena Dumin, Elena Kartvelishvily, Pu Li, Rogerio Panizzutti, Maria Shleper

Publikováno v: Journal of Biological Chemistry. 280:1754-1763

Mammalian brain contains high levels of d-serine, an endogenous co-agonist of N-methyl D-aspartate type of glutamate receptors. D-Serine is synthesized by serine racemase, a brain enriched enzyme converting L- to D-serine. Degradation of D-serine is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220348e9c77016c66d72ade99a8901cc
https://doi.org/10.1074/jbc.m405726200

FBXO22 Protein Is Required for Optimal Synthesis of the N-Methyl-d-Aspartate (NMDA) Receptor Coagonist d-Serine*

Autor: Martin Zehl, Veronika N. Foltyn, Ole N. Jensen, Herman Wolosker, Hisashi Mori, Elena Dikopoltsev, Inna Radzishevsky

Publikováno v: Dikopoltsev, E, Foltyn, V N, Zehl, M, Jensen, O N, Mori, H, Radzishevsky, I & Wolosker, H 2014, ' FBXO22 Protein Is Required for Optimal Synthesis of the N-Methyl-d-Aspartate (NMDA) Receptor Coagonist d-Serine ', Journal of Biological Chemistry, vol. 289, no. 49, pp. 33904-15 . https://doi.org/10.1074/jbc.M114.618405

d-Serine is a physiological activator of NMDA receptors (NMDARs) in the nervous system that mediates several NMDAR-mediated processes ranging from normal neurotransmission to neurodegeneration. d-Serine is synthesized from l-serine by serine racemase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8add030e75c6c345f25a561ec59b8c
https://europepmc.org/articles/PMC4256329/

Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane

Autor: Herman Wolosker, Elena Dumin, Diana Knoh, Ole N. Jensen, Yusuke Ohno, Martin Zehl, Elena Dikopoltsev, Inna Radzishevsky, Akio Kihara, Livia Balan, Veronika N. Foltyn

Publikováno v: Balan, L, Foltyn, V N, Zehl, M, Dumin, E, Dikopoltsev, E, Knoh, D, Ohno, Y, Kihara, A, Jensen, O N, Radzishevsky, I S & Wolosker, H 2009, ' Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane ', Proceedings of the National Academy of Science of the United States of America, vol. 106, no. 18, pp. 7589-7594 . https://doi.org/10.1073/pnas.0809442106

D-serine is a physiological coagonist of N-methyl D-aspartate receptors (NMDARs) that plays a major role in several NMDAR-dependent events. In this study we investigate mechanisms regulating D-serine production by the enzyme serine racemase (SR). We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f92dfdfd65645a726dc48b467088c58
https://portal.findresearcher.sdu.dk/da/publications/6a8fb2d0-4ab2-11de-b5e8-000ea68e967b