An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Autor: Elmar Christ, Martin Suchan, Kathrin Kuna, Yasmina Ouchan, Lena M. Kranz, Klaus Kühlcke, Oliver Klein, Arne Billmeier, Özlem Türeci, Kristina Michel, David Weber, Petra Oehm, Matthias Birtel, Katharina Reinhard, Thomas Bukur, Ugur Sahin, Benjamin Rengstl, Kathleen Hobohm, Karolina Anna Mroz, Mustafa Diken, Veronika Jahndel, Stefan Wöll, Nina Hayduk

Publikováno v: Science (New York, N.Y.). 367(6476)

A one-two, CAR-T cell punch Chimeric antigen receptor (CAR)–T cells have been clinically effective in killing certain hematological malignancies, but achieving long-term patient responses for solid tumors remains a challenge. Reinhard et al. descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595fec9e13a20870ea02c75610274796
https://pubmed.ncbi.nlm.nih.gov/32020073

Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species

Autor: Peter M. Brophy, James E. LaCourse, Steve Paterson, Toby Wilkinson, Khalid M. Saifullah, Paul McVeigh, Gopalakrishnan Ravikumar, Russell M. Morphew, S.M.A. Abidi, Aaron G. Maule, Veronika Jahndel, Muthusamy Raman, Neil Douglas MacKintosh

Publikováno v: Morphew, R M, Wilkinson, T J, Mackintosh, N, Jahndel, V, Paterson, S, McVeigh, P, Abbas Abidi, S M, Saifullah, K, Raman, M & Ravikumar, G 2016, ' Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species ', Journal Of Proteome Research, vol. 15, no. 9, pp. 3308-3321 . https://doi.org/10.1021/acs.jproteome.6b00331

The liver flukes Fasciola hepatica and F. gigantica infect livestock worldwide and threaten food security with climate change and problematic control measures spreading disease. Fascioliasis is also a foodborne disease with up to 17 million humans in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c8fd3437d996498db88ebfc89b3e37
https://doi.org/10.1021/acs.jproteome.6b00331

The Tolerogenic Function of Annexins on Apoptotic Cells Is Mediated by the Annexin Core Domain

Autor: Heiko Weyd, Lucie Abeler-Dörner, Peter H. Krammer, Linda Linke, Andrea Mahr, Alexandra Kurz, Björn Linke, Veronika Jahndel, Sandra Pfrang

Publikováno v: The Journal of Immunology. 194:5233-5242

Immunological tolerance is constantly being maintained in the periphery by dendritic cells processing material from apoptotic cells (ACs) in the steady-state. Although research has focused on the uptake of ACs by phagocytes, tolerogenic signals expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bdc0cdecbba14de69cf2e11cde4d6d
https://doi.org/10.4049/jimmunol.1401299

Abstract CT032: A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles for potent cancer immunotherapy in patients with malignant melanoma

Autor: Daniel Fritz, Doreen Schwarck-Kokarakis, Nicole Bidmon, Ulrich Luxemburger, Klaus Kuehlcke, Richard Rae, Sebastian Attig, Fatih Sari, Oezlem Tuereci, Kristina Spieß, Sebastian Kreiter, Andreas Kuhn, Christine Seck, Jochen Utikal, Peter Langguth, Janina Buck, Meike Witt, Alexandra Kemmer-Brueck, Heinrich Haas, Martin Meng, Felicitas Mueller, Ugur Sahin, Mustafa Diken, Evelyna Derhovanessian, Lena M. Kranz, Veronika Jahndel, Jan Diekmann, Christoph Huber, Jessica C. Hassel, Carmen Loquai, Roland Kaufmann, Robert A. Jabulowsky

Publikováno v: Cancer Research. 76:CT032-CT032

Immunotherapeutic approaches have evolved as promising and valid alternatives to available conventional cancer treatments. Amongst others, vaccination with tumor antigen-encoding RNAs by local administration is currently successfully employed in vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa596e6d4d73862eeff06f69fb9acef3
https://doi.org/10.1158/1538-7445.am2016-ct032