Výsledky vyhledávání - "Veronika Škedelj"

Akademický článek

Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases

Autor: Martina Hrast, Kaja Rožman, Iza Ogris, Veronika Škedelj, Delphine Patin, Matej Sova, Hélène Barreteau, Stanislav Gobec, Simona Golič Grdadolnik, Anamarija Zega

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1010-1017 (2019)

The Mur ligases form a series of consecutive enzymes that participate in the intracellular steps of bacterial peptidoglycan biosynthesis. They therefore represent interesting targets for antibacterial drug discovery. MurC, D, E and F are all ATP-depe

Externí odkaz: https://doaj.org/article/611a82a2fe88425aaa24c3fa2a9502bd

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Akademický článek

6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase.

Autor: Veronika Škedelj, Emilija Arsovska, Tihomir Tomašić, Ana Kroflič, Vesna Hodnik, Martina Hrast, Marija Bešter-Rogač, Gregor Anderluh, Stanislav Gobec, Julieanne Bostock, Ian Chopra, Alex J O'Neill, Christopher Randall, Anamarija Zega

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e39922 (2012)

BACKGROUND: ATP-dependent D-alanine:D-alanine ligase (Ddl) is a part of biochemical machinery involved in peptidoglycan biosynthesis, as it catalyzes the formation of the terminal D-ala-D-ala dipeptide of the peptidoglycan precursor UDPMurNAc-pentape

Externí odkaz: https://doaj.org/article/c1d486e583d44c8eac076f7ed3fbdb08

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H Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases

Autor: Kaja Rožman, Delphine Patin, Stanislav Gobec, Matej Sova, Hélène Barreteau, Veronika Škedelj, Simona Golic Grdadolnik, Iza Ogris, Anamarija Zega, Martina Hrast

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2019, 34 (1), pp.1010--1017. ⟨10.1080/14756366.2019.1608981⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1010-1017 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.1010--1017. ⟨10.1080/14756366.2019.1608981⟩

International audience; The Mur ligases form a series of consecutive enzymes that participate in the intracellular steps of bacterial peptidoglycan biosynthesis. They therefore represent interesting targets for antibacterial drug discovery. MurC, D,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1932abd8087edcfa8a7927f6fa884665
https://hal.archives-ouvertes.fr/hal-02171151

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Kinetic mechanism of Enterococcus faeciumd-aspartate ligase

Autor: Peter Molek, Veronika Škedelj, Jure Stojan, Anamarija Zega, Didier Blanot, Jean-Luc Mainardi, Urša Pečar Fonović, Stanislav Gobec, Sophie Magnet

Publikováno v: Biochimie
Biochimie, Elsevier, 2019, 158, pp.217--223. ⟨10.1016/j.biochi.2019.01.012⟩
Biochimie, 2019, 158, pp.217--223. ⟨10.1016/j.biochi.2019.01.012⟩

International audience; Enterococcus faecium D-aspartate ligase (Aslfm) is a peptide bond-forming enzyme that is involved in the peptidoglycan assembly pathway. It catalyzes the ATP-dependent ligation of the β-carboxylate of D-Asp to the ε-amino gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2198eb15e512c726fba6474f1980d0ea
https://pubmed.ncbi.nlm.nih.gov/30682389

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ATP-Binding Site of Bacterial Enzymes as a Target for Antibacterial Drug Design

Autor: Lucija Peterlin Mašič, Tihomir Tomašič, Veronika Škedelj, Anamarija Zega

Publikováno v: Journal of Medicinal Chemistry. 54:915-929

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bb9bc3fe0d6ddb3125e638a33387e0
https://doi.org/10.1021/jm101121s

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Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm)

Autor: Jure Stojan, Matjaž Brvar, Ana Kroflič, Victoria J. Savage, Jean-Luc Mainardi, Anamarija Zega, Vincent Dubbée, Alex J. O'Neill, Tom Solmajer, Didier Blanot, Andrej Perdih, Michel Arthur, Jean-Emmanuel Hugonnet, Marija Bešter-Rogač, Sophie Magnet, Veronika Škedelj

Publikováno v: European journal of medicinal chemistry. 67

The d -aspartate ligase of Enterococcus faecium (Asl fm ) is an attractive target for the development of narrow-spectrum antibacterial agents that are active against multidrug-resistant E. faecium. Although there is currently little available informa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e260d0eb905a3d3f007cf64ed28f4448
https://pubmed.ncbi.nlm.nih.gov/23867605

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6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase

Autor: Christopher P. Randall, Julieanne M. Bostock, Tihomir Tomašič, Marija Bešter-Rogač, Ian Chopra, Ana Kroflič, Veronika Škedelj, Stanislav Gobec, Martina Hrast, Anamarija Zega, Gregor Anderluh, Vesna Hodnik, Alex J. O'Neill, Emilija Arsovska

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e39922 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacb7bc0b5c9a9d609504483f46817d5
http://europepmc.org/articles/PMC3410885?pdf=render

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