Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy

Autor: Tomas Smolek, Veronika Cubinkova, Veronika Brezovakova, Bernadeta Valachova, Peter Szalay, Norbert Zilka, Santosh Jadhav

Publikováno v: Frontiers in Aging Neuroscience, Vol 11 (2019)

Alzheimer’s disease (AD), the most common tauopathy, is an age-dependent, progressive neurodegenerative disease. Epidemiological studies implicate the role of genetic background in the onset and progression of AD. Despite mutations in familial AD,

Externí odkaz: https://doaj.org/article/b20010c9f4f44b43a9000c599811f726

Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models

Autor: Yanyan Zhao, Ole Tietz, Veronika Cubinkova, Norbert Žilka, Lindsay McMurray, Aviva M. Tolkovsky, Tomas Smolek, David W. Williamson, Jennifer A. Macdonald, Nisha K. Ramakrishnan, Michel Goedert, Xiaoyun Zhou, Steven G. Fagan, Franklin I. Aigbirhio, Steven Kealey, Maria Grazia Spillantini

Publikováno v: ACS Chem. Neurosci.
ACS Chemical Neuroscience

Aggregated tau protein is a core pathology present in several neurodegenerative diseases. Therefore, the development and application of positron emission tomography (PET) imaging radiotracers that selectively bind to aggregated tau in fibril form is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1d06b6ef04db1a6140b61714530ea0

Spinal Cord Injury: Animal Models, Imaging Tools and the Treatment Strategies

Autor: Zuzana Mojzisova, Isabelle Fournier, Filip Humenik, Adriana-Natalia Murgoci, Marcela Maloveska, Veronika Cubinkova, Milan Cizek, Michel Salzet, Dasa Cizkova

Publikováno v: Neurochemical Research
Neurochemical Research, Springer Verlag, 2020, 45 (1), pp.134-143. ⟨10.1007/s11064-019-02800-w⟩
Neurochemical Research, 2020, 45 (1), pp.134-143. ⟨10.1007/s11064-019-02800-w⟩

International audience; Spinal cord injury (SCI) often leads to irreversible neuro-degenerative changes with life-long consequences. While there is still no effective therapy available, the results of past research have led to improved quality of lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9dec6427313decff5b9959ea6ba425
https://www.hal.inserm.fr/inserm-02941635

Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy

Autor: Bernadeta Valachova, Tomas Hromadka, Santosh Jadhav, Peter Filipcik, Norbert Zilka, Petronela Weisová, Veronika Brezovakova, Michal Novak, Tomas Smolek, Veronika Cubinkova, Ivana Zimova

Publikováno v: Journal of Alzheimer's Disease. 54:831-843

Alzheimer's disease (AD) represents the most common neurodegenerative disorder. Several animal models have been developed in order to test pathophysiological mechanisms of the disease and to predict effects of pharmacological interventions. Here we e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2249af343f0d4a1b6da445560d2e8c
https://doi.org/10.3233/jad-160347

Dynamics of Evans blue clearance from cerebrospinal fluid into meningeal lymphatic vessels and deep cervical lymph nodes

Autor: Dasa Cizkova, Marcela Maloveska, Veronika Cubinkova, Lenka Kresakova, Andrej Kovac, Katarina Vdoviakova, Jan Danko, Eva Petrovova, Alena Michalicova

Publikováno v: Neurological research. 40(5)

Objectives Recently, it has been confirmed, that excess fluid and waste products from the brain are drained into the cerebrospinal fluid (CSF) and afterwards cleared via the olfactory route and/or lymphatic vessels in the brain dura and corresponding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40e232431957ca4ff736ab0d76a7a19
https://pubmed.ncbi.nlm.nih.gov/29619904