Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Veronick Benoy"'
Autor:
Wenting Guo, Maximilian Naujock, Laura Fumagalli, Tijs Vandoorne, Pieter Baatsen, Ruben Boon, Laura Ordovás, Abdulsamie Patel, Marc Welters, Thomas Vanwelden, Natasja Geens, Tine Tricot, Veronick Benoy, Jolien Steyaert, Cynthia Lefebvre-Omar, Werend Boesmans, Matthew Jarpe, Jared Sterneckert, Florian Wegner, Susanne Petri, Delphine Bohl, Pieter Vanden Berghe, Wim Robberecht, Philip Van Damme, Catherine Verfaillie, Ludo Van Den Bosch
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Amyotrophic lateral sclerosis (ALS) leads to selective loss of motor neurons. Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are ob
Externí odkaz:
https://doaj.org/article/f59dc3e6db71437985afab751df3c753
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 300-320 (2017)
Peripheral neuropathies are characterized by a progressive and length-dependent loss of peripheral nerve function. This can be caused either by genetic defects, classified as ‘inherited peripheral neuropathies’, or they can be acquired throughout
Externí odkaz:
https://doaj.org/article/e682f9c0866c4c3d84e021581525b5aa
Autor:
Zsofia Kutil, Brett Langley, Veronick Benoy, Sida Shen, Cristina Picci, Cyril Bařinka, Matthew B. Robers, Ludo Van Den Bosch, Alan P. Kozikowski, Jiří Pavlíček, Chad Zimprich, Guiping Zhang, Kseniya Ustinova, Maurício Temotheo Tavares
Publikováno v:
Journal of medicinal chemistry. 64(8)
Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent an
Autor:
Chris Van den Haute, Sarah van Veen, Johannes V. Swinnen, Roeland Vanhoutte, Jean-Paul Decuypere, Jeffrey Zielich, Joseph A. Lyons, Bart Ghesquière, Géraldine Gelders, Veronick Benoy, Eric J. Lambie, Wim Annaert, Shaun Martin, Veerle Baekelandt, Peter Vangheluwe, Patrizia Agostinis, Jan Eggermont, Jan Pascal Kahler, Steven H. L. Verhelst
ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated in a spectrum of neurodegenerative disorders, including Kufor-Rakeb syndrome—a parkinsonism with dementia1—and early-onset Parkinson’s disease2. ATP13A2 offers p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b02281bb2e77f9e2f4beaaa1f265428
https://lirias.kuleuven.be/handle/123456789/649573
https://lirias.kuleuven.be/handle/123456789/649573
Autor:
Delphine Bohl, Natasja Geens, Wenting Guo, Tijs Vandoorne, Cynthia Lefebvre-Omar, Catherine M. Verfaillie, Ludo Van Den Bosch, Thomas Vanwelden, Wim Robberecht, Laura Fumagalli, Werend Boesmans, Laura Ordovás, Jared Sterneckert, Jolien Steyaert, Tine Tricot, Maximilian Naujock, Ruben Boon, Susanne Petri, Marc Welters, Pieter Vanden Berghe, Philip Van Damme, Florian Wegner, Abdulsamie Patel, Veronick Benoy, Matthew Jarpe, Pieter Baatsen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications, 2017, 8 (1), pp.394-405. ⟨10.1038/s41467-017-00911-y⟩
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.394-405. ⟨10.1038/s41467-017-00911-y⟩
Cell Stress
Nature Communications
Nature Communications, 2017, 8 (1), pp.394-405. ⟨10.1038/s41467-017-00911-y⟩
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.394-405. ⟨10.1038/s41467-017-00911-y⟩
Cell Stress
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characteri
Publikováno v:
Cold Spring Harb Perspect Biol
Calcium ions (Ca(2+)) are prominent cell signaling effectors that regulate a wide variety of cellular processes. Among the different players in Ca(2+) homeostasis, primary active Ca(2+) transporters are responsible for keeping low basal Ca(2+) levels
Autor:
Cyril Bařinka, Matthew B. Robers, Richard S. Jope, Veronick Benoy, Sida Shen, Ludo Van Den Bosch, Maurício Temotheo Tavares, Dora Szarics, Alan P. Kozikowski, Marta Pardo, James H. Eubanks, Chad Zimprich, Zsofia Kutil, Guiping Zhang
Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there are no effective treatments or cures. Herein, we report on a tetrahydroquinoline-based selective histone deacetylase 6 (HDAC6) inhibitor SW-100, its pharmacologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62914a7bbc2c9a6aa75a1ffbfb32bff9
https://europepmc.org/articles/PMC6512341/
https://europepmc.org/articles/PMC6512341/
Autor:
Constantin d’Ydewalle, Philip Van Damme, Wendy Scheveneels, Pieter Vanden Berghe, Lawrence Van Helleputte, Veronick Benoy, Wanda Haeck, Wim Robberecht, Begga Schevenels, Natasja Geens, Ludo Van Den Bosch, Alan P. Kozikowski, Kevin Talbot, M. Zameel Cader, Robert Prior
Publikováno v:
Brain
Patients with Charcot-Marie-Tooth disease with predominant axonal loss (CMT2) show extensive genetic heterogeneity. Benoy et al. demonstrate a link between CMT2 and histone deacetylase 6 (HDAC6), which controls the acetylation of α-tubulin, and prop
Publikováno v:
Neurobiology of Disease, Vol 105, Iss, Pp 300-320 (2017)
Peripheral neuropathies are characterized by a progressive and length-dependent loss of peripheral nerve function. This can be caused either by genetic defects, classified as 'inherited peripheral neuropathies', or they can be acquired throughout lif
Autor:
Tom Desmet, Matthias D'hooghe, Jorick Franceus, Kristof Van Hecke, Yves Depetter, Lisa Galle, Veronick Benoy, Rob De Vreese, Ludo Van Den Bosch
Publikováno v:
CHEMISTRY-A EUROPEAN JOURNAL
Selective inhibitors of histone deacetylase 6 (HDAC6) are an emerging class of pharmaceuticals due to the involvement of HDAC6 in different pathways related to neurodegenerative diseases, cancer, and immunology. Herein, the synthesis of ten new benzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1134616b91dacbd790df6c368ef895df
https://biblio.ugent.be/publication/8500783
https://biblio.ugent.be/publication/8500783