Výsledky vyhledávání - "Veronica Segredo"

A Constitutively Internalizing and Recycling Mutant of the μ-Opioid Receptor

Autor: Veronica Segredo, Jelveh Lameh, Neil T. Burford, Wolfgang Sadee

Publikováno v: Journal of Neurochemistry. 68:2395-2404

Internalization and recycling of G protein-coupled receptors (GPCRs), such as the μ-opioid receptor, largely depend on agonist stimulation, whereas certain other receptor types recycle constitutively, e.g., the transferrin receptor. To investigate s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5999aa965785e00cf95cab9b5415f7c8
https://doi.org/10.1046/j.1471-4159.1997.68062395.x

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The Pharmacokinetics and Neuromuscular Effects of Rocuronium Bromide in Patients with Liver Disease

Autor: James E. Caldwell, Janos Szenohradszky, T. Magorian, Paul M. Wood, Manohar Sharma, Ronald D. Miller, Larry D. Gruenke, Veronica Segredo, Dennis M. Fisher

Publikováno v: Anesthesia & Analgesia. 80:754-759

To determine the effect of liver disease on the pharmacokinetics of rocuronium, the authors administered 0.6 mg/kg (twice the ED95) to 10 patients with liver disease and compared these results to values in 10 healthy surgical patients. Anesthesia was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38829c47cb93a7d56f4912ddc77497f6
https://doi.org/10.1213/00000539-199504000-00018

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Constitutive Activation of the μ-Opioid Receptor: A Novel Paradigm of Receptor Regulation in Narcotic Analgesia, Tolerance, and Dependence

Autor: Wolfgang Sadee, James R. Arden, Zaijie Wang, Veronica Segredo

Publikováno v: Analgesia. 1:11-14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c1173eefae6c88db5fa2d11bec05437
https://doi.org/10.3727/107156994819564474

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Persistent Paralysis in Critically Ill Patients after Long-Term Administration of Vecuronium

Autor: Michael A. Matthay, L. D. Gruenke, Ronald D. Miller, Manohar Sharma, James E. Caldwell, Veronica Segredo

Publikováno v: New England Journal of Medicine. 327:524-528

The muscle relaxant vecuronium is sometimes administered to facilitate mechanical ventilation. Neuromuscular paralysis lasting up to seven days may occur after the termination of long-term administration (i.e., more than two days) of vecuronium in cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b8c33e46d3e424d117d7d23bd2b5e7
https://doi.org/10.1056/nejm199208203270804

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Pharmacokinetics, Neuromuscular Effects, and Biodisposition of 3-Desacetylvecuronium (Org 7268) in Cats

Autor: Manohar Sharma, Veronica Segredo, K. S. Khuenl-Brady, Ronald D. Miller, Sandor Agoston, Yang Sik Shin, Larry D. Gruenke, James E. Caldwell

Publikováno v: Anesthesiology. 74:1052-1059

The pharmacokinetics, biodisposition, and neuromuscular blocking properties of 3-desacetylvecuronium were studied in 17 adult cats. Animals were divided into three groups: five cats with kidney failure induced by bilateral ligation of the renal pedic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c83139c303e2354efe4ff810486c42
https://doi.org/10.1097/00000542-199106000-00013

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Effect of remifentanil on pain and secondary hyperalgesia associated with the heat--capsaicin sensitization model in healthy volunteers

Autor: Michael C. Rowbotham, Veronica Segredo, Karin L. Petersen, Jørgen B. Dahl, Bruce Jones

Publikováno v: Anesthesiology. 94(1)

Background The heat--capsaicin sensitization model was developed as a noninvasive and noninjurious human experimental pain model. The sequential application of moderate intensity thermal and topical chemical stimuli produces stable and long-lasting a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438e894ca12f71f3ae4e90995a5950c
https://pubmed.ncbi.nlm.nih.gov/11135717

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Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells

Autor: Veronica Segredo, Jelveh Lameh, James R. Arden, Wolfgang Sadee, Zaijie Wang

Publikováno v: Journal of neurochemistry. 65(4)

We expressed the cloned mu-opioid receptor (muR) in high abundance (5.5 x 10(6) sites/cell) with an amino-terminal epitope tag (EYMPME) in human embryonic kidney 293 cells. The epitope-tagged receptor (EE-muR) was similar to the untagged mu R ligand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2395962486504280094ac10f2aa984
https://pubmed.ncbi.nlm.nih.gov/7561859

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Do the Pharmacokinetics of Vecuronium Change During Prolonged Administration in Critically Ill Patients?

Autor: James E. Caldwell, Veronica Segredo, Peter M. C. Wright, L. D. Gruenke, Ronald D. Miller, Manohar Sharma

Publikováno v: Survey of Anesthesiology. 43:261-262

Neuromuscular blocking drugs may be administered over several days to patients in the intensive care unit (ICU), but their pharmacokinetics have been studied at only one point in time, or assumed to be constant throughout the period of administration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c8f99f9e34a8c63795bec39e696ef3
https://doi.org/10.1097/00132586-199910000-00016

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