Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Veronica Sacchi"'
Autor:
Veronica Sacchi, Bingyan J. Wang, Dieter Kubli, Alexander S. Martinez, Jung‐Kang Jin, Roberto Alvarez, Nirmala Hariharan, Christopher Glembotski, Takafumi Uchida, James S. Malter, Yijun Yang, Polina Gross, Chen Zhang, Steven Houser, Marcello Rota, Mark A. Sussman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 10 (2017)
BackgroundAberrant Ca2+ handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca2+ handling is essential for the development of strategies to blunt pathological changes in calcium dynamics.
Externí odkaz:
https://doaj.org/article/6a2db19b32c94847a8eac79c834c6bb5
Autor:
Maximilian G. Burger, Andrea Grosso, Priscilla S. Briquez, Gordian M.E. Born, Alexander Lunger, Flavio Schrenk, Atanas Todorov, Veronica Sacchi, Jeffrey A. Hubbell, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio
Publikováno v:
Acta biomaterialia. 149
Rapid vascularization of clinical-size bone grafts is an unsolved challenge in regenerative medicine. Vascular endothelial growth factor-A (VEGF) is the master regulator of angiogenesis. Its over-expression by genetically modified human osteoprogenit
Publikováno v:
Vascularization for Tissue Engineering and Regenerative Medicine ISBN: 9783319545844
Vascularization for Tissue Engineering and Regenerative Medicine ISBN: 9783319210568
Vascularization for Tissue Engineering and Regenerative Medicine
Vascularization for Tissue Engineering and Regenerative Medicine ISBN: 9783319210568
Vascularization for Tissue Engineering and Regenerative Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20232a6e0cc2d782c0a765f153d9e5bb
https://doi.org/10.1007/978-3-319-54586-8_6
https://doi.org/10.1007/978-3-319-54586-8_6
Autor:
Megan M. Monsanto, Veronica Sacchi, Christina R. Payne, Natalie Gude, Walter P. Dembitsky, Kristine Nguyen, Fareheh Firouzi, David E. Ebeid, Barbara A. Bailey, Jop H. van Berlo, Mark A. Sussman, Alexandria Casillas, Farid G. Khalafalla, Roberto Alvarez, Kathleen M. Broughton, Kelli Ilves, Bingyan J. Wang
Publikováno v:
Circulation Research. 123:57-72
Rationale: Biological significance of c-Kit as a cardiac stem cell marker and role(s) of c-Kit+ cells in myocardial development or response to pathological injury remain unresolved because of varied and discrepant findings. Alternative experimental m
Autor:
Farid G. Khalafalla, Mirko Völkers, Fareheh Firouzi, Kelli Korski, Megan M. Monsanto, Mathias H. Konstandin, Carolina Y Esquer, Julian M. Navarrete, Kathleen M. Broughton, Maryam Moshref, Mark A. Sussman, Roberto Alvarez, Natalie Gude, David E. Ebeid, Nirmala Hariharan, Jonathan Nguyen, Marie Jose Goumans, Bingyan J. Wang, Pearl Quijada, Jacqueline Emathinger, Veronica Sacchi, Christopher T. Cottage
Publikováno v:
Cardiovascular Research, 117(1), 201-211. OXFORD UNIV PRESS
Aims Telomere attrition in cardiomyocytes is associated with decreased contractility, cellular senescence, and up-regulation of proapoptotic transcription factors. Pim1 is a cardioprotective kinase that antagonizes the aging phenotype of cardiomyocyt
Autor:
Petra Korpisalo‐Pirinen, Marianna Trani, Elena Groppa, Andrea Uccelli, Sime Brkic, Silvia Reginato, Manuele G. Muraro, Veronica Sacchi, Galina Wirth, Roberto Gianni-Barrera, Seppo Ylä-Herttuala, Andrea Banfi, Maria Filippova, Boris Dasen
Publikováno v:
EMBO Reports
Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best‐understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative process of intussusceptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3a87281f91186648c4ce2d53a4a1c7
Autor:
Roberto Alvarez, James S. Malter, Marcello Rota, Yijun Yang, Chen Zhang, Bingyan J. Wang, Dieter A Kubli, Takafumi Uchida, Veronica Sacchi, Polina Gross, Nirmala Hariharan, Mark A. Sussman, Alexander Martinez, Jung-Kang Jin, Steven R. Houser, Christopher C. Glembotski
Publikováno v:
Journal of the American Heart Association. 6
Background Aberrant Ca 2+ handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca 2+ handling is essential for the development of strategies to blunt pathological changes in calcium dynami
Autor:
Natalie A Gude, Fareheh Firouzi, Kristine Nguyen, Christina Payne, Veronica Sacchi, Roberto Alvarez, Mark A Sussman
Publikováno v:
Circulation Research. 121
Background: The biological significance of c-Kit as a marker of cardiac stem cells, and role(s) of c-Kit+ cells in myocardial development or in response to pathologic injury remain unresolved due to varied findings among investigators and experimenta
Autor:
Anna Hofmann, Elena Groppa, Heinz Redl, Lorentz Kristen Marie, Martin Ehrbar, Jeffrey A. Hubbell, Mikaël M. Martino, Susanne Wolbank, Jeffrey S. Marschall, Joachim Hartinger, Veronica Sacchi, Roberto Gianni-Barrera, Remo A. Largo, Andrea Banfi, Rainer Mittermayr
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene delivery failed to show efficacy. Major challenges include the need to precisely control in vivo distribution of growth factor dose and duration of expressi
Autor:
Mirko Voelkers, Roberto Alvarez, Silvia Truffa, Anya Y. Joyo, Natalie Gude, Pearl Quijada, Haruhiro Toko, Mark A. Sussman, Veronica Sacchi, Marlo Villanueva, Nirmala Hariharan, Eri Joyo
Publikováno v:
Basic Research in Cardiology. 110
Phase I clinical trials applying autologous progenitor cells to treat heart failure have yielded promising results; however, improvement in function is modest, indicating a need to enhance cardiac stem cell reparative capacity. Notch signaling plays