Výsledky vyhledávání - "Veronica Reinhart"

Akademický článek

Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling

Autor: Wei Chou Tseng, Veronica Reinhart, Thomas A. Lanz, Mark L. Weber, Jincheng Pang, Kevin Xuong Vinh Le, Robert D. Bell, Patricio O’Donnell, Derek L. Buhl

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Schizophrenia is a complex and heterogenous disease that presents with abnormalities in glutamate signaling and altered immune and inflammatory signals. Genome-wide association studies have indicated specific genes and pathways that may cont

Externí odkaz: https://doaj.org/article/78b4111fc55c48a39108af05d438929d

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Akademický článek

Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder

Autor: Veronica Reinhart, Susan E. Bove, Dmitri Volfson, David A. Lewis, Robin J. Kleiman, Thomas A. Lanz

Publikováno v: Neurobiology of Disease, Vol 77, Iss , Pp 220-227 (2015)

Brain-derived neurotrophic factor (BDNF) signaling is integral to a range of neural functions, including synaptic plasticity and exhibits activity-dependent regulation of expression. As altered BDNF signaling has been implicated in multiple psychiatr

Externí odkaz: https://doaj.org/article/0d41d5db21884363b76e9422d51fbd34

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Akademický článek

STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder.

Autor: Thomas A Lanz, J Julie Joshi, Veronica Reinhart, Kjell Johnson, Lonnie E Grantham, Dmitri Volfson

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121744 (2015)

Increased protein levels of striatal-enriched tyrosine phosphatase (STEP) have recently been reported in postmortem schizophrenic cortex. The present study sought to replicate this finding in a separate cohort of postmortem samples and to extend obse

Externí odkaz: https://doaj.org/article/ae2a7f90b8fe4fcca7d6f1d2e16d1b37

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Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling

Autor: Derek L. Buhl, Wei Chou Tseng, Veronica Reinhart, Mark L. Weber, Kevin Xuong Vinh Le, Jincheng Pang, Robert D. Bell, Patricio O'Donnell, Thomas A. Lanz

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry

Schizophrenia is a complex and heterogenous disease that presents with abnormalities in glutamate signaling and altered immune and inflammatory signals. Genome-wide association studies have indicated specific genes and pathways that may contribute to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2619ad2223bbd4ca7735da010c02dc
https://doaj.org/article/78b4111fc55c48a39108af05d438929d

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Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder

Autor: Dmitri Volfson, Robin J. Kleiman, David A. Lewis, Larry C. James, Veronica Reinhart, Stacey J. Sukoff Rizzo, Thomas A. Lanz, Mark J. Sheehan, Susan E. Bove

Publikováno v: Translational Psychiatry, Vol 9, Iss 1, Pp 1-13 (2019)
Translational Psychiatry

Psychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) arise from complex interactions between genetic and environmental factors. Common genetic variants associated with multiple psychiatric diso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e747e135284c5544071733f2d834a9f
http://link.springer.com/article/10.1038/s41398-019-0492-8

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Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor Activation

Autor: Susan M. Lotarski, Sarah Grimwood, Michael Popiolek, Veronica Reinhart, Jeremy R. Edgerton, Jennifer E. Davoren, Stefanus J. Steyn, John F. Harms, David P. Nguyen

Publikováno v: Biochemistry. 55:7073-7085

The rationale for using M1 selective muscarinic acetylcholine receptor activators for the treatment of cognitive impairment associated with psychiatric and neurodegenerative disease is well-established in the literature. Here, we investigate measurem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7d948042e32f463780f579df4556d74
https://doi.org/10.1021/acs.biochem.6b00688

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Select 3′,5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain

Autor: Robin J. Kleiman, Alexander J. Hartman, Alison Romegialli, Abigail Mariga, Veronica Reinhart, Michy P. Kelly, Geetanjali Pathak, Susan E. Bove, Wendy O. Adamowicz

Publikováno v: Cellular Signalling. 26:383-397

3',5'-cyclic nucleotide phosphodiesterases (PDEs) are the only known enzymes to compartmentalize cAMP and cGMP, yet little is known about how PDEs are dynamically regulated across the lifespan. We mapped mRNA expression of all 21 PDE isoforms in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a965e2641b05e6676e6d0909585ea2
https://doi.org/10.1016/j.cellsig.2013.10.007

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