Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates

Autor: Alexander, Kukalev, Yiu-Ming, Ng, Limei, Ju, Amal, Saidi, Sophie, Lane, Angeles, Mondragon, Dirk, Dormann, Sophie E, Walker, William, Grey, Philip Wing-Lok, Ho, David N, Stephens, Antony M, Carr, Karri, Lamsa, Eric, Tse, Veronica P C C, Yu

Publikováno v: Cerebral Cortex (New York, NY)

In mitotic cells, the cyclin-dependent kinase (CDK) subunit protein CKS1 regulates S phase entry by mediating degradation of the CDK inhibitor p27. Although mature neurons lack mitotic CDKs, we found that CKS1 was actively expressed in post-mitotic n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f8b1340dc8201504f8395829f1124fa
https://pubmed.ncbi.nlm.nih.gov/28365778

Cks1 Activates Transcription by Binding to the Ubiquitylated Proteasome

Autor: Edward J. Andress, Veronica P. C. C. Yu, Mariola J. Edelmann, Conny W. H. Yu, Ivy Lau, Alexander Kukalev, Roman Holic, Benedikt M. Kessler, Sophie Lane

Publikováno v: Molecular and Cellular Biology. 30:3894-3901

Transcription is a complex process, which involves multiple levels of regulation. Cks proteins are evolutionarily conserved and bind cyclin-dependent kinases with high affinity (7). In the budding yeast Saccharomyces cerevisiae, Cks1 binds the cell c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03654de969cb5a94932d4336f4aa41d
https://doi.org/10.1128/mcb.00655-09

Deficiency of the cyclin-dependent kinase inhibitor, CDKN1B, results in overgrowth and neurodevelopmental delay

Autor: Louise Izatt, Veronica P. C. C. Yu, Yiu-Ming Ng, Caroline Mackie Ogilvie, Roman Holic, Wafa Sahraoui, Eric Tse, Anthony J Hulse, William Grey

Publikováno v: Human Mutation

Germline mutations in the cyclin-dependent kinase inhibitor, CDKN1B, have been described in patients with multiple endocrine neoplasia (MEN), a cancer predisposition syndrome with adult onset neoplasia and no additional phenotypes. Here, we describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daca7d4f82a46e20b310f99e027e5b44
http://hdl.handle.net/10722/186031

Cks1, Cdk1, and the 19S Proteasome Collaborate To Regulate Gene Induction-Dependent Nucleosome Eviction in Yeast▿

Autor: Susana R. Chaves, Christopher Baskerville, Steven I. Reed, Veronica P. C. C. Yu

Cks1, Cdk1 (Cdc28), and the proteasome are required for efficient transcriptional induction of GAL1 and other genes in Saccharomyces cerevisiae. We show here that one function of these proteins is to reduce nucleosome density on chromatin in a gene i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3f87408ac61a05585876fc0576f32c
https://europepmc.org/articles/PMC2976369/

Unusual presentation of Lynch Syndrome

Autor: Veronica P. C. C. Yu, Audrey Ardern-Jones, S. J. Payne, David Goudie, Ros Eeles, Susan Shanley, Marco Novelli, Ann Barrett, Sam Fisher, Ian M. Frayling, Rebecca A. Barnetson

Publikováno v: Hereditary Cancer in Clinical Practice
Yu, V P C C, Novelli, M, Payne, S J, Fisher, S, Barnetson, R A, Frayling, I M, Barrett, A, Goudie, D, Ardern-Jones, A, Eeles, R & Shanley, S 2009, ' Unusual presentation of Lynch Syndrome ', Hereditary cancer in clinical practice, vol. 7, no. 1, 12 . https://doi.org/10.1186/1897-4287-7-12
Hereditary Cancer in Clinical Practice, Vol 7, Iss 1, p 12 (2009)

Lynch Syndrome/HNPCC is a syndrome of cancer predisposition linked to inherited mutations of genes participating in post-replicative DNA mismatch repair (MMR). The spectrum of cancer associated with Lynch Syndrome includes tumours of the colorectum,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837d3181d7458c993bccb4589c90d464
https://pubmed.ncbi.nlm.nih.gov/19493351