Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Veronica Novotny‐Diermayr"'
Autor:
Vincenzo Teneggi, Veronica Novotny‐Diermayr, Lay Hoon Lee, Maryam Yasin, Pauline Yeo, Kantharaj Ethirajulu, Sylvia Bong Hwa Gan, Stephanie E. Blanchard, Ranjani Nellore, Dhananjay N. Umrani, Roberto Gomeni, Darren Lim Wan Teck, Greg Li, Qing Shu Lu, Yang Cao, Alex Matter
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 57-66 (2020)
In the last decade, drug development has tackled substantial challenges to improve efficiency and facilitate access to innovative medicines. Integrated clinical protocols and the investigation of targeted oncology drugs in healthy volunteers (HVs) ha
Externí odkaz:
https://doaj.org/article/17e8ef4d9a8f43f8922705a7b52f3953
Autor:
Nicholas C. DeVito, Michael Sturdivant, Balamayooran Thievanthiran, Christine Xiao, Michael P. Plebanek, April K.S. Salama, Georgia M. Beasley, Alisha Holtzhausen, Veronica Novotny-Diermayr, John H. Strickler, Brent A. Hanks
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109071- (2021)
Summary: While immune checkpoint blockade is associated with prolonged responses in multiple cancers, most patients still do not benefit from this therapeutic strategy. The Wnt-β-catenin pathway is associated with diminished T cell infiltration; how
Externí odkaz:
https://doaj.org/article/7d2f5f4e3fbf4817a9bfc19438eefb1b
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
XLS file - 167K, Table 1: Cell line drug sensitivity data for SB2343 and mutations in cancer genes. Table 2: Results from MANOVA analysis of cancer genes as modifiers of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794bb76ff68be2e6a52cec2e5c03efb5
https://doi.org/10.1158/1535-7163.22497418
https://doi.org/10.1158/1535-7163.22497418
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 2.9MB, In-vitro kinase assay, Histology, Cell proliferation, MANOVA analysis for genomic correlates of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ecb3048e6ff5affcb194a51978b5d1
https://doi.org/10.1158/1535-7163.22497421
https://doi.org/10.1158/1535-7163.22497421
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 663K, Ambit kinome tree, Cell proliferation data, Pharmacokinetics, Body weight changes in PC3 efficacy study, Active vessel stain in COLO-205 efficacy study, MV4-11 efficacy model, Drug sensitivity profiling and correlation to mutation st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407e7e397fec9712aed4f01696117bc4
https://doi.org/10.1158/1535-7163.22497424
https://doi.org/10.1158/1535-7163.22497424
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
Dysregulation of the PI3K/mTOR pathway, either through amplifications, deletions, or as a direct result of mutations, has been closely linked to the development and progression of a wide range of cancers. Moreover, this pathway activation is a poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389efae3908c20bd53e37aa050195e71
https://doi.org/10.1158/1535-7163.c.6535609
https://doi.org/10.1158/1535-7163.c.6535609
Autor:
Jeanette Marjorie Wood, Joy Zhu, Kantharaj Ethirajulu, Han-Chong Toh, Boon-Cher Goh, Wei-Peng Yong, Hannes Hentze, Ramesh Jayaraman, Mohammed Khalid Pasha, Yung Kiang Loh, Nina Sausgruber, Veronica Novotny-Diermayr
SB939 is an oral histone deacetylase (HDAC) inhibitor currently in phase II clinical trials potently inhibiting class I, II, and IV HDACs with favorable pharmacokinetic properties, resulting in tumor tissue accumulation. To show target efficacy, a We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a33fd5835618140d404352e513debfa
https://doi.org/10.1158/1535-7163.c.6535455
https://doi.org/10.1158/1535-7163.c.6535455
Autor:
Jeanette Marjorie Wood, Joy Zhu, Kantharaj Ethirajulu, Han-Chong Toh, Boon-Cher Goh, Wei-Peng Yong, Hannes Hentze, Ramesh Jayaraman, Mohammed Khalid Pasha, Yung Kiang Loh, Nina Sausgruber, Veronica Novotny-Diermayr
Supplementary Methods, Figures 1-2, Tables 1-2 from Pharmacodynamic Evaluation of the Target Efficacy of SB939, an Oral HDAC Inhibitor with Selectivity for Tumor Tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67afc5b454d6b303b05ea9c843a6757
https://doi.org/10.1158/1535-7163.22496979
https://doi.org/10.1158/1535-7163.22496979
Autor:
Heinz-Josef Lenz, Dominik Wolf, Emil Lou, Martin D. Berger, Zlatko Trajanoski, Arno Amann, W. Michael Korn, Chadi Nabhan, Gek San Tan, Kiat Hon Lim, Paul E. Sackstein, Benjamin A. Weinberg, John L. Marshall, Anthony F. Shields, Axel Grothey, Richard M. Goldberg, Michelle Ellis, Jeff Swensen, Alberto Puccini, Dietmar Rieder, Veronica Novotny-Diermayr, Gilbert Spizzo, Joanne Xiu, Yasmine Baca, Florian Kocher, Kai Zimmer, Francesca Battaglin, Andreas Seeber
Supplementary Table from Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0146bbdd153b0ea4c010876127b8d934
https://doi.org/10.1158/1078-0432.22488182
https://doi.org/10.1158/1078-0432.22488182
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Figures and Materials and Metholds from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b51e86e9b7513857bdd252443925fa
https://doi.org/10.1158/1535-7163.22485351.v1
https://doi.org/10.1158/1535-7163.22485351.v1