Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Autor: Josepmaria Argemi, Maria U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquin Cabezas, Juan J. Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan P. Arab, Meritxell Ventura-Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Odena, Juan L. Gomez, Tomas Aragon, Jose Altamirano, Juan Caballeria, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho-Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark R. Thursz, Jelena Mann, Matias A. Avila, Ramon Bataller

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)

Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or

Externí odkaz: https://doaj.org/article/0fb71062dc154a909e1831b9bf41223d

Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension

Autor: Pau Sancho-Bru, Rajanikanth Vadigepalli, Bin Gao, Ramon Bataller, Yan Cai, Shizuo Akira, Juan Caballería, Pere Ginès, Natasha T. Snider, Joaquín Cabezas, Jiegen Chen, Veronica Massey, Ivan Rusyn, Josepmaria Argemi, José Altamirano, Mingjiang Xu, Austin Parrish, Gemma Odena

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports

Advanced fibrosis and portal hypertension influence short-term mortality. Lipocalin 2 (LCN2) regulates infection response and increases in liver injury. We explored the role of intrahepatic LCN2 in human alcoholic hepatitis (AH) with advanced fibrosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b94184036a6dd8494e372fbe3031ec6
http://link.springer.com/article/10.1038/s41598-020-72172-7

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH

Autor: Sara Omenetti, Lauren Ashley Cowart, L. Frenguelli, Ramon Bataller, Massimo Pinzani, Josepmaria Argemi, Ana Levi, Francesco De Chiara, Mark Kester, Sriram S. Shanmugavelandy, Fausto Andreola, Todd E. Fox, Lisa Longato, F. Zanieri, Juan Caballería, David J. Montefusco, Krista Rombouts, Giuseppe Mazza, Veronica Massey, Tu Vinh Luong, Constantino Fondevila

Publikováno v: Cells, Vol 9, Iss 1237, p 1237 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Cells
Volume 9
Issue 5

In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic lipid accumulation. Recently, the role of dysfunctional sphingolipid metabolism has also been proposed. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d79a7061966fac8e1f1608b66f25cbd
https://www.mdpi.com/2073-4409/9/5/1237

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Autor: Gemma Odena, Jelena Mann, Lia R. Edmunds, Juan Pablo Arab, Aaron Bell, Stephen R. Atkinson, Pau Sancho-Bru, Satdarshan P.S. Monga, Peter Stärkel, Joel P. Gue, Maria U. Latasa, Juan Caballería, Matías A. Avila, Alexandre Louvet, Sheng Cao, Juan Luis Gomez, Claes Wahlestedt, Marsha Y. Morgan, Juan José Lozano, Philippe Mathurin, José Altamirano, Derek J. Van Booven, Laurent Dubuquoy, Ramon Bataller, Ilya O. Blokhin, Shinji Furuya, Constantino Fondevilla, D. Lansing Taylor, Veronica Massey, Ivan Rusyn, Mark Thursz, Michael J. Jurczak, Tomás J. Aragón, Carolin Lackner, Lawrence Vernetti, Vijay H. Shah, Josepmaria Argemi, Meritxell Ventura-Cots, Joaquín Cabezas, Carmen Berasain

Publikováno v: Nature Communications
Nature Communications, 2019, Nature Communications, 10 (1), pp.3126. ⟨10.1038/s41467-019-11004-3⟩
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Scientia
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Nature Communications, Nature Publishing Group, 2019, Nature Communications, 10 (1), pp.3126. ⟨10.1038/s41467-019-11004-3⟩
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature communications, Vol. 10, no. 1, p. 3126 [1-19] (2019)

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900dfe4b907dbab0ee9b21afc4bd0024
https://ddd.uab.cat/record/223727

Epigenetics in Liver Fibrosis

Autor: Veronica Massey, Joaquín Cabezas, Ramon Bataller

Publikováno v: Seminars in liver disease. 37(3)

Liver fibrosis is a common consequence of chronic liver injury and is a key determinant of liver-associated morbidity and mortality. Identification of new mechanisms of fibrosis, including disease-specific molecular drivers, remains relevant to revea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0a9eeff294b2498674f53107ed995f
https://pubmed.ncbi.nlm.nih.gov/28847033