The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes

Autor: Veronica Lang, Peter E Light

Publikováno v: Pharmacogenomics and Personalized Medicine, Vol 2010, Iss default, Pp 145-161 (2010)

Veronica Lang, Peter E LightDepartment of Pharmacology and Alberta Diabetes Institute, Faculty of Medicine and Dentistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, CanadaAbstract: Neonatal diabetes mellitus (

Externí odkaz: https://doaj.org/article/6ec9233723304710b48f5aabde181b41

Apparent Lack of BRAFV600E Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8+ T Cells in Langerhans Cell Histiocytosis

Autor: Paul G. Kemps, Timo C. Zondag, Eline C. Steenwijk, Quirine Andriessen, Jelske Borst, Sandra Vloemans, Dave L. Roelen, Lenard M. Voortman, Robert M. Verdijk, Carel J. M. van Noesel, Arjen H. G. Cleven, Cynthia Hawkins, Veronica Lang, Arnoud H. de Ru, George M. C. Janssen, Geert W. Haasnoot, Kees L. M. C. Franken, Ronald van Eijk, Nienke Solleveld-Westerink, Tom van Wezel, R. Maarten Egeler, Auke Beishuizen, Jan A. M. van Laar, Oussama Abla, Cor van den Bos, Peter A. van Veelen, Astrid G. S. van Halteren

Publikováno v: Frontiers in Immunology, 10:3045. Frontiers Media S.A.
Frontiers in immunology, 10. Frontiers Media S.A.
Frontiers in Immunology, 10. FRONTIERS MEDIA SA
Frontiers in Immunology, Vol 10 (2020)

Langerhans Cell Histiocytosis (LCH) is a neoplastic disorder of hematopoietic origin characterized by inflammatory lesions containing clonal histiocytes (LCH-cells) intermixed with various immune cells, including T cells. In 50-60% of LCH-patients, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16ee33415361be0bcb63b76235642c4
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078689874&origin=inward

The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes

Autor: Veronica Lang, Nermeen Youssef, Peter E. Light

Publikováno v: Current diabetes reports. 11(6)

Sulfonylurea receptors (SURs) form an integral part of the ATP-sensitive potassium (K(ATP)) channel complex that is present in most excitable cell types. K(ATP) channels couple cellular metabolism to electrical activity and provide a wide range of ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fd6da66f781990b2c6b78f6f0f5b5a
https://pubmed.ncbi.nlm.nih.gov/21968738