Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Veronica J, Alexander"'
Autor:
Bastian Ramms, Sohan Patel, Chelsea Nora, Ariane R. Pessentheiner, Max W. Chang, Courtney R. Green, Gregory J. Golden, Patrick Secrest, Ronald M. Krauss, Christian M. Metallo, Christopher Benner, Veronica J. Alexander, Joseph L. Witztum, Sotirios Tsimikas, Jeffrey D. Esko, Philip L.S.M. Gordts
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 8, Pp 1379-1395 (2019)
Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We r
Externí odkaz:
https://doaj.org/article/79b2fc472cb54420abab601c33268491
Autor:
Elif A. Oral, Abhimanyu Garg, Joseph Tami, Eric A. Huang, Louis St.L. O'Dea, Hartmut Schmidt, Anatoly Tiulpakov, Ann Mertens, Veronica J. Alexander, Lynnetta Watts, Eunju Hurh, Joseph L. Witztum, Richard S. Geary, Sotirios Tsimikas
Publikováno v:
Journal of Clinical Lipidology. 16:833-849
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a511815ca92594eaecdb3be627b967ea
https://doi.org/10.1016/j.jacl.2022.08.008
https://doi.org/10.1016/j.jacl.2022.08.008
Autor:
Ewa Karwatowska-Prokopczuk, Jean-Claude Tardif, Daniel Gaudet, Christie M. Ballantyne, Michael D. Shapiro, Patrick M. Moriarty, Seth J. Baum, Eric St Amour, Veronica J. Alexander, Shuting Xia, James D. Otvos, Joseph L. Witztum, Sotirios Tsimikas
Publikováno v:
Journal of Clinical Lipidology. 16:617-625
Olezarsen is a hepatocyte-targeted, GalNAc-modified antisense oligonucleotide that decreases plasma levels of apolipoprotein C-III (apoC-III) and triglyceride-rich lipoproteins (TRLs).To define the effect of olezarsen on NMR-derived lipoprotein parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a1a318ab7ac2a72462312d99c8a5ad
https://doi.org/10.1016/j.jacl.2022.06.005
https://doi.org/10.1016/j.jacl.2022.06.005
Autor:
Thomas A. Prohaska, Veronica J. Alexander, Ewa Karwatowska-Prokopczuk, Joseph Tami, Shuting Xia, Joseph L. Witztum, Sotirios Tsimikas
Publikováno v:
Journal of Clinical Lipidology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4057abe644298dc6a620d6d97fc0cf2b
https://doi.org/10.1016/j.jacl.2023.04.007
https://doi.org/10.1016/j.jacl.2023.04.007
Autor:
Xiaohong Yang, Sang-Rok Lee, Yun-Seok Choi, Veronica J. Alexander, Andres Digenio, Qingqing Yang, Yury I. Miller, Joseph L. Witztum, Sotirios Tsimikas
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 4, Pp 706-713 (2016)
Elevated apoC-III levels predict increased cardiovascular risk when present on LDL and HDL particles. We developed novel high-throughput chemiluminescent ELISAs that capture apoB, lipoprotein (a) [Lp(a)], and apoA-I in plasma and then detect apoC-III
Externí odkaz:
https://doaj.org/article/40bbe240a7034b35bb4e01f1c165f503
Autor:
Joseph L. Witztum, Daniel Gaudet, Marcello Arca, Alan Jones, Handrean Soran, Ioanna Gouni-Berthold, Erik S.G. Stroes, Veronica J. Alexander, Richard Jones, Lynnetta Watts, Shuting Xia, Sotirios Tsimikas
Publikováno v:
Journal of clinical lipidology. Elsevier BV
Background: Familial chylomicronemia syndrome (FCS) is a rare, autosomal recessive genetic disorder characterized by a marked increase in plasma triglyceride (TG) levels and recurrent episodes of pancreatitis. The response to conventional TG-lowering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1052cc26ee75bd7c1928cdbf0b5957dc
https://pure.amc.nl/en/publications/volanesorsen-and-triglyceride-levels-in-familial-chylomicronemia-syndrome(a3f9f939-3b5b-42ec-bad2-09efad6f3b67).html
https://pure.amc.nl/en/publications/volanesorsen-and-triglyceride-levels-in-familial-chylomicronemia-syndrome(a3f9f939-3b5b-42ec-bad2-09efad6f3b67).html
Autor:
Jean-Claude Tardif, Ewa Karwatowska-Prokopczuk, Eric St Amour, Christie M Ballantyne, Michael D Shapiro, Patrick M Moriarty, Seth J Baum, Eunju Hurh, Victoria J Bartlett, Joyce Kingsbury, Amparo L Figueroa, Veronica J Alexander, Joseph Tami, Joseph L Witztum, Richard S Geary, Louis St L O’Dea, Sotirios Tsimikas, Daniel Gaudet
Publikováno v:
European heart journal, vol 43, iss 14
Aims Hypertriglyceridaemia is associated with increased risk of cardiovascular events. This clinical trial evaluated olezarsen, an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab435f70ddb9874ac3d5d38b0c089f7
https://escholarship.org/uc/item/52k3p81s
https://escholarship.org/uc/item/52k3p81s
Autor:
Lauré M. Fijen, Marc A. Riedl, Laura Bordone, Jonathan A. Bernstein, Jason Raasch, Raffi Tachdjian, Timothy Craig, William R. Lumry, Michael E. Manning, Veronica J. Alexander, Kenneth B. Newman, Alexey Revenko, Brenda F. Baker, Charvi Nanavati, A. Robert MacLeod, Eugene Schneider, Danny M. Cohn
Publikováno v:
The New England journal of medicine, 386(11), 1026-1033. Massachussetts Medical Society
BACKGROUND: Hereditary angioedema is characterized by recurrent and unpredictable swellings that are disabling and potentially fatal. Selective inhibition of plasma prekallikrein production by antisense oligonucleotide treatment (donidalorsen) may re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a16b30232910dd9e1208365ce91cad3
https://pubmed.ncbi.nlm.nih.gov/35294818
https://pubmed.ncbi.nlm.nih.gov/35294818
Autor:
Gwendolyn E. Kaeser, Richard S Geary, Danny M. Cohn, Brenda F. Baker, Shuting Xia, Marcel Levi, Nicholas J. Viney, Lauré M. Fijen, Erik S.G. Stroes, Charvi Nanavati, Joost C. M. Meijers, Eugene Schneider, Veronica J Alexander
Publikováno v:
New England journal of medicine, 383(13), 1242-1247. Massachussetts Medical Society
Hereditary angioedema is characterized by recurrent and unpredictable episodes of subcutaneous and mucosal swelling that can be life threatening. IONIS-PKK-LRx is a ligand-conjugated antisense oligonucleotide designed for receptor-mediated delivery t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbaabd31b958b313a998dbacd6b6902a
https://doi.org/10.1056/nejmoa1915035
https://doi.org/10.1056/nejmoa1915035
Autor:
Louis O'Dea, Richard S. Geary, Eunju Hurh, Veronica J. Alexander, Kristin Balogh, Lynnetta Watts, Ewa Karwatowska-Prokopczuk, Sotirios Tsimikas
Publikováno v:
Nucleic Acid Therapeutics. 30:198-206
The aim of this study was to assess the effect of volanesorsen on the corrected QT (QTc) interval. This thorough QT study enrolled 52 healthy male and female subjects who were randomized at a singl...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d58d2ba6edce51833df1ea253692149
https://doi.org/10.1089/nat.2019.0837
https://doi.org/10.1089/nat.2019.0837