Výsledky vyhledávání - "Veronica H Ryan"

Akademický článek

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex.

Autor: Stanley I Rapoport, Christopher T Primiani, Chuck T Chen, Kwangmi Ahn, Veronica H Ryan

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132675 (2015)

Phosphoinositides, lipid-signaling molecules, participate in diverse brain processes within a wide metabolic cascade.Gene transcriptional networks coordinately regulate the phosphoinositide cascade during human brain Development and Aging.We used the

Externí odkaz: https://doaj.org/article/009a9046770a4d68aea5aeecd2f6c77a

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Akademický článek

Coordination of gene expression of arachidonic and docosahexaenoic acid cascade enzymes during human brain development and aging.

Autor: Veronica H Ryan, Christopher T Primiani, Jagadeesh S Rao, Kwangmi Ahn, Stanley I Rapoport, Helene Blanchard

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e100858 (2014)

The polyunsaturated arachidonic and docosahexaenoic acids (AA and DHA) participate in cell membrane synthesis during neurodevelopment, neuroplasticity, and neurotransmission throughout life. Each is metabolized via coupled enzymatic reactions within

Externí odkaz: https://doaj.org/article/13edbb7310bf47f584e52ba8189885e9

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Akademický článek

Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging.

Autor: Christopher T Primiani, Veronica H Ryan, Jagadeesh S Rao, Margaret C Cam, Kwangmi Ahn, Hiren R Modi, Stanley I Rapoport

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110972 (2014)

BACKGROUND:Age changes in expression of inflammatory, synaptic, and neurotrophic genes are not well characterized during human brain development and senescence. Knowing these changes may elucidate structural, metabolic, and functional brain processes

Externí odkaz: https://doaj.org/article/8765b6f04a7e47c7845c4b40f654f11c

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Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

Publikováno v: bioRxiv

Functional loss of TDP-43, an RNA-binding protein genetically and pathologically linked to ALS and FTD, leads to inclusion of cryptic exons in hundreds of transcripts during disease. Cryptic exons can promote degradation of affected transcripts, dele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52de4bfdb559430326ffc82718aa6b2a
https://europepmc.org/articles/PMC9900763/

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Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid–liquid phase separation and aggregation

Autor: Scott Watters, Balabhadra Khatiwada, Nicolas L. Fawzi, Vincenzo Venditti, Mandar T. Naik, Joshua Amaya, Veronica H Ryan

Publikováno v: Nucleic Acids Research

hnRNPA2 is a major component of mRNA transport granules in oligodendrocytes and neurons. However, the structural details of how hnRNPA2 binds the A2 recognition element (A2RE) and if this sequence stimulates granule formation by enhancing phase separ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9d6ec3cf3c335c6d2d4de82dd2dd59
http://europepmc.org/articles/PMC7544213

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Physiological, Pathological, and Targetable Membraneless Organelles in Neurons

Autor: Veronica H Ryan, Nicolas L. Fawzi

Publikováno v: Trends Neurosci

Neurons require unique subcellular compartmentalization to function efficiently. Formed from proteins and RNAs through liquid-liquid phase separation, membraneless organelles have emerged as one way in which cells form distinct, specialized compartme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba147fb1635f979ab60a7de4bf5cb46
https://doi.org/10.1016/j.tins.2019.08.005

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The SH3 domain of Fyn kinase interacts with and induces liquid–liquid phase separation of the low-complexity domain of hnRNPA2

Autor: Veronica H Ryan, Nicolas L. Fawzi, Joshua Amaya

Publikováno v: Journal of Biological Chemistry. 293:19522-19531

Liquid–liquid phase separation of proteins and nucleic acids into membraneless organelles (MLOs) spatially organizes cellular components and reactions. The RNA-binding protein heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2) carries mRNA target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c4ac1b3863982a96c089ee17a6a381
https://doi.org/10.1074/jbc.ra118.005120

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Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration

Autor: Camillo F Saueressig, Jeetain Mittal, Gregory L. Dignon, Nicolas L. Fawzi, Theodora Myrto Perdikari, Mandar T. Naik, Veronica H Ryan, Anne C. Hart, Jeremy Lins

Publikováno v: The EMBO Journal

mRNA transport in neurons requires formation of transport granules containing many protein components, and subsequent alterations in phosphorylation status can release transcripts for translation. Further, mutations in a structurally disordered domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743bf9455975e58a47592183f7790502
https://doi.org/10.15252/embj.2020105001

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SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs

Autor: Veronica H Ryan, Anastasia C Murthy, Scott Watters, Mandar T. Naik, Nicolas L. Fawzi, Theodora Myrto Perdikari

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1

Tightly packed complexes of nucleocapsid protein and genomic RNA form the core of viruses and may assemble within viral factories, dynamic compartments formed within the host cells. Here, we examine the possibility that the multivalent RNA-binding nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d3d7f31a367b0239e63a3d4b69611f
https://doi.org/10.15252/embj.2020106478

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