Modeling riboflavin transporter deficiency type 2: from iPSC-derived motoneurons to iPSC-derived astrocytes

Autor: Valentina Magliocca, Angela Lanciotti, Elena Ambrosini, Lorena Travaglini, Veronica D’Ezio, Valentina D’Oria, Stefania Petrini, Michela Catteruccia, Keith Massey, Marco Tartaglia, Enrico Bertini, Tiziana Persichini, Claudia Compagnucci

Publikováno v: Frontiers in Cellular Neuroscience, Vol 18 (2024)

IntroductionRiboflavin transporter deficiency type 2 (RTD2) is a rare neurodegenerative autosomal recessive disease caused by mutations in the SLC52A2 gene encoding the riboflavin transporters, RFVT2. Riboflavin (Rf) is the precursor of FAD (flavin a

Externí odkaz: https://doaj.org/article/92b000ce458745bdb05cc0b0d313f8ab

Amyloid-β 25-35 Induces Neurotoxicity through the Up-Regulation of Astrocytic System Xc−

Autor: Veronica D’Ezio, Marco Colasanti, Tiziana Persichini

Publikováno v: Antioxidants, Vol 10, Iss 11, p 1685 (2021)

Amyloid-β (Aβ) deposition, a hallmark of Alzheimer’s disease, is known to induce free radical production and oxidative stress, leading to neuronal damage. During oxidative stress, several cell types (including astrocytes) can activate the nuclear

Externí odkaz: https://doaj.org/article/1dc1c18c82e54289a339152b5689121f

Iron saturation drives lactoferrin effects on oxidative stress and neurotoxicity induced by HIV-1 tat

Autor: Giusi Ianiro, Veronica D’Ezio, Ludovica Carpinelli, Cecilia Casella, Maria Carmela Bonaccorsi di Patti, Luigi Rosa, Piera Valenti, Marco Colasanti, Giovanni Musci, Antimo Cutone, Tiziana Persichini

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 7947

The Trans-Activator of Transcription (Tat) of Human Immunodeficiency Virus (HIV-1) is involved in virus replication and infection and can promote oxidative stress in human astroglial cells. In response, host cells activate transcription of antioxidan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f79fff8c29c742d65457b5c333ebd1
https://hdl.handle.net/11573/1679588

Unraveling the role of male reproductive tract and haemolymph in cantharidin-exuding Lydus trimaculatus and Mylabris variabilis (Coleoptera: Meloidae): a comparative transcriptomics approach

Autor: Veronica D’Ezio, Manuela Cervelli, Marco Molfini, Silvia Gisondi, Maurizio Muzzi, Fabrizio Lombardo, Elia Roma, Marco Alberto Bologna, Andrea Di Giulio, Emiliano Fratini, Tecla Gasperi, Marco Salvemini, Tiziana Persichini, Emiliano Mancini, Paolo Mariottini

Publikováno v: BMC Genomics
Fratini, E, Salvemini, M, Lombardo, F, Muzzi, M, Molfini, M, Gisondi, S, Roma, E, D’Ezio, V, Persichini, T, Gasperi, T, Mariottini, P, Di Giulio, A, Bologna, M A, Cervelli, M & Mancini, E 2021, ' Unraveling the role of male reproductive tract and haemolymph in cantharidin-exuding Lydus trimaculatus and Mylabris variabilis (Coleoptera: Meloidae) : a comparative transcriptomics approach ', BMC Genomics, vol. 22, 808 . https://doi.org/10.1186/s12864-021-08118-8
BMC Genomics, Vol 22, Iss 1, Pp 1-24 (2021)

Background Meloidae (blister beetles) are known to synthetize cantharidin (CA), a toxic and defensive terpene mainly stored in male accessory glands (MAG) and emitted outward through reflex-bleeding. Recent progresses in understanding CA biosynthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0931ac5281e718870178c91fbb684d
https://pubmed.ncbi.nlm.nih.gov/34749651

An integrated approach for chemical water quality assessment of an urban river stretch through Effect-Based Methods and emerging pollutants analysis with a focus on genotoxicity

Autor: Valentina Marra, Walter Cristiano, Gessica Gorbi, Antonella Sgura, Serena Montalbano, Mara Palumbo, Veronica D’Ezio, Vittoria Scarcelli, Giada Frenzilli, Valentina Prota, Anna Maria Ingelido, Annamaria Buschini, Ines Lacchetti, Ion Udroiu, Laura Mancini, Mario Carere, Margherita Bernardeschi, Antonio Suppa, Francesca De Battistis, Kevin Di Domenico, Martina Valenzuela, Patrizia Guidi, Massimiliano Scalici, Elena De Felip, Nicola Iacovella, Francesca Marcon, Antonio Antoccia, Tiziana Persichini, Riccardo Massei, Marco Colasanti, Federica Spani, Cristina Andreoli

Publikováno v: Journal of Environmental Management. 300:113549

The impact of emerging chemical pollutants, on both status and functionality of aquatic ecosystems is worldwide recognized as a relevant issue of concern that should be assessed and managed by researchers, policymakers, and all relevant stakeholders.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e72ee6d4fa8d04bfa04d30a1df43a6
https://doi.org/10.1016/j.jenvman.2021.113549