Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Veronica Craik"'
Autor:
Stefan Gahbauer, Chelsea DeLeon, Joao M. Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B. Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A. Fink, Ivan S. Kondratov, Yurii S. Moroz, John J. Irwin, Allan I. Basbaum, Bryan L. Roth, Brian K. Shoichet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting prostagl
Externí odkaz:
https://doaj.org/article/5afef5b1703241589164379113e645d4
Autor:
Julia A Kuhn, Ilia D Vainchtein, Joao Braz, Katherine Hamel, Mollie Bernstein, Veronica Craik, Madelene W Dahlgren, Jorge Ortiz-Carpena, Ari B Molofsky, Anna V Molofsky, Allan I Basbaum
Publikováno v:
eLife, Vol 10 (2021)
Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition characterized by mechanical hypersensitivity. We previously identified microglial activation via release of colony-stimulating factor 1 (CSF1) from injured senso
Externí odkaz:
https://doaj.org/article/62a134c3d95e44b3af89fbe8fc850844
Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.
Autor:
Christopher G Alvaro, João M Braz, Mollie Bernstein, Katherine A Hamel, Veronica Craik, Hiroki Yamanaka, Allan I Basbaum
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0226289 (2020)
Calcium binding proteins are expressed throughout the central and peripheral nervous system and disruption of their activity has major consequences in a wide array of cellular processes, including transmission of nociceptive signals that are processe
Externí odkaz:
https://doaj.org/article/cbbd54fce8cc44f990eeb3d7cb03f3bb
Autor:
Isha Singh, Anubha Seth, Christian B. Billesbølle, Joao Braz, Ramona M. Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Vladimir M. Pogorelov, Parnian Lak, Henry O’Donnell, Walter Sandtner, John J. Irwin, Bryan L. Roth, Allan I. Basbaum, William C. Wetsel, Aashish Manglik, Brian K. Shoichet, Gary Rudnick
Publikováno v:
Cell, vol 186, iss 10
The serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, occluded, and inward-open. All known inhibitors target the outward-open state except ibogaine, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d58613557bb5172a1708dafaffcd158
https://escholarship.org/uc/item/5cg0t59n
https://escholarship.org/uc/item/5cg0t59n
Autor:
Tia A. Tummino, Christos Iliopoulos-Tsoutsouvas, Joao M. Braz, Evan S. O’Brien, Reed M. Stein, Veronica Craik, Ngan K. Tran, Suthakar Ganapathy, Yuki Shiimura, Fei Tong, Thanh C. Ho, Dmytro S. Radchenko, Yurii S. Moroz, Fangyu Liu, Sian Rodriguez Rosado, Karnika Bhardwaj, Jorge Benitez, Yongfeng Liu, Herthana Kandasamy, Claire Normand, Meriem Semache, Laurent Sabbagh, Isabella Glenn, John J. Irwin, Kaavya Krishna Kumar, Alexandros Makriyannis, Allan I. Basbaum, Brian K. Shoichet
Docking tangible virtual libraries can reveal unexpected chemotypes that complement the structures of biological targets. Seeking new agonists for the cannabinoid-1 receptor (CB1R), we docked 74 million tangible molecules, prioritizing 46 high rankin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f866fdd249e0ce3cd2d9772403b5cafc
https://doi.org/10.1101/2023.02.27.530254
https://doi.org/10.1101/2023.02.27.530254
Autor:
Assaf Alon, Jiankun Lyu, Joao M. Braz, Tia A. Tummino, Veronica Craik, Matthew J. O’Meara, Chase M. Webb, Dmytro S. Radchenko, Yurii S. Moroz, Xi-Ping Huang, Yongfeng Liu, Bryan L. Roth, John J. Irwin, Allan I. Basbaum, Brian K. Shoichet, Andrew C. Kruse
Publikováno v:
Nature
Nature, vol 600, iss 7890
Nature, vol 600, iss 7890
The σ(2) receptor has attracted intense interest in cancer imaging(1), psychiatric disease(2), neuropathic pain(3–5), and other areas of biology(6,7). We determined the crystal structure of this receptor in complex with the clinical candidate rolu
Autor:
Elissa A. Fink, Jun Xu, Harald Hübner, Joao M. Braz, Philipp Seemann, Charlotte Avet, Veronica Craik, Dorothee Weikert, Maximilian F. Schmidt, Chase M. Webb, Nataliya A. Tolmachova, Yurii S. Moroz, Xi-Ping Huang, Chakrapani Kalyanaraman, Stefan Gahbauer, Geng Chen, Zheng Liu, Matthew P. Jacobson, John J. Irwin, Michel Bouvier, Yang Du, Brian K. Shoichet, Allan I. Basbaum, Peter Gmeiner
Publikováno v:
Science. 377
Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α 2A -adrenergic receptor (α 2A AR), seeking new α 2A AR agonists chemotypes that lack the s
Autor:
Isha Singh, Anubha Seth, Christian B. Billesbølle, Joao Braz, Ramona M. Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Parnian Lak, Henry O’Donnell, Walter Sandtner, Bryan L. Roth, Allan I. Basbaum, William C. Wetsel, Aashish Manglik, Brian K. Shoichet, Gary Rudnick
SUMMARYThe serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, occluded, and inward-open. All known inhibitors target the outward-open state except ibogain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5895a65a89afbdc8ac539061b017cdf2
https://doi.org/10.1101/2022.06.13.495991
https://doi.org/10.1101/2022.06.13.495991
Autor:
Anat Levit Kaplan, Ryan T. Strachan, Joao M. Braz, Veronica Craik, Samuel Slocum, Thomas Mangano, Vanessa Amabo, Henry O’Donnell, Parnian Lak, Allan I. Basbaum, Bryan L. Roth, Brian Shoichet
Publikováno v:
Journal of medicinal chemistry, vol 65, iss 5
J Med Chem
J Med Chem
The 5-HT5A receptor (5-HT5AR), for which no selective agonists and only a few antagonists exist, remains the least understood serotonin (5-HT) receptor. A single commercial antagonist (SB-699551) has been widely used to investigate central nervous sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192ee3a80586cb56d73c824b54aae90d
https://doi.org/10.1101/2021.12.06.471449
https://doi.org/10.1101/2021.12.06.471449
Autor:
Ilia D Vainchtein, Julia A Kuhn, Joao Braz, Katherine Hamel, Mollie Bernstein, Veronica Craik, Madelene W Dahlgren, Jorge Ortiz-Carpena, Ari B Molofsky, Anna V Molofsky, Allan I Basbaum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12a68c168093a02d8f44b98dcc1b6f3e
https://doi.org/10.7554/elife.69056.sa2
https://doi.org/10.7554/elife.69056.sa2