Výsledky vyhledávání - "Veronica Codoni"

Akademický článek

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

Autor: Veronica Codoni, Yuna Blum, Mete Civelek, Carole Proust, Oscar Franzén, Cardiogenics Consortium, IDEM Leducq Consortium CADGenomics, Johan L. M. Björkegren, Wilfried Le Goff, Francois Cambien, Aldons J. Lusis, David-Alexandre Trégouët

Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3361-3371 (2016)

Macrophages are key players involved in numerous pathophysiological pathways and an in-depth characterization of their gene regulatory networks can help in better understanding how their dysfunction may impact on human diseases. We here conducted a c

Externí odkaz: https://doaj.org/article/6400e4b80771417f88d84779bd8eaf01

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Akademický článek

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States.

Autor: Le Shu, Kei Hang K Chan, Guanglin Zhang, Tianxiao Huan, Zeyneb Kurt, Yuqi Zhao, Veronica Codoni, David-Alexandre Trégouët, Cardiogenics Consortium, Jun Yang, James G Wilson, Xi Luo, Daniel Levy, Aldons J Lusis, Simin Liu, Xia Yang

Publikováno v: PLoS Genetics, Vol 13, Iss 9, p e1007040 (2017)

Cardiovascular diseases (CVD) and type 2 diabetes (T2D) are closely interrelated complex diseases likely sharing overlapping pathogenesis driven by aberrant activities in gene networks. However, the molecular circuitries underlying the pathogenic com

Externí odkaz: https://doaj.org/article/9b65189309924c46a788c2d5b8b67fa5

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Computational analysis of 10,860 phenotypic annotations in individuals with SCN2A-related disorders

Autor: Margaret O'Brien, Shridhar Parthasarathy, Eryn Fitch, Ingo Helbig, Roland Krause, Shiva Ganesan, Veronica Codoni, Katherine Crawford, Deanne Taylor, Colin A Ellis, Julie Xian, Peter D. Galer, David Lewis-Smith, Katherine L. Helbig, Michael C. Kaufman, Laura Conway

Publikováno v: Genetics in Medicine

Purpose Pathogenic variants in SCN2A cause a wide range of neurodevelopmental phenotypes. Reports of genotype–phenotype correlations are often anecdotal, and the available phenotypic data have not been systematically analyzed. Methods We extracted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5e4ae9a9e2de3de283b91378c05449
https://doi.org/10.1038/s41436-021-01120-1

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High-Risk Clonal Hematopoiesis as the Origin of AITL and NPM1-Mutated AML

Autor: Veronica Codoni, Valeria Cardinali, Gianluca Schiavoni, Maria Paola Martelli, Andrea Marra, Stefano Ascani, Enrico Tiacci, Brunangelo Falini, Alessandra Venanzi, Giovanni Martino

Publikováno v: New England Journal of Medicine

Two Cancers in CHIP A patient with clonal hematopoiesis of indeterminate potential (CHIP) received the diagnosis of lymphoma with activation of RHOA. Approximately 1 year later, NPM1-mutated acute ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822ea26b7bac8a0e3639888d5bf1567f
https://doi.org/10.1056/nejmc1806413

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Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

Autor: François Cambien, Johan Björkegren, Yuna Blum, Veronica Codoni, Wilfried Le Goff, Oscar Franzén, Mete Civelek, David-Alexandre Trégouët, Carole Proust, Aldons J. Lusis

Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3361-3371 (2016)
G3
G3, 2016, 6 (10), pp.3361-3371. ⟨10.1534/g3.116.033894⟩
G3: Genes|Genomes|Genetics
G3, Genetics Society of America, 2016, 6 (10), pp.3361-3371. ⟨10.1534/g3.116.033894⟩

Cardiogenics Consortium, IDEM Leducq Consortium CADGenomics; International audience; Macrophages are key players involved in numerous pathophysiological pathways and an in-depth characterization of their gene regulatory networks can help in better un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65daad712dfeb126f227d76ab546ede8
http://g3journal.org/lookup/doi/10.1534/g3.116.033894

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Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function

Autor: Yuna Blum, Henri Weidmann, Mete Civelek, Aldons J. Lusis, Zahia Touat-Hamici, Veronica Codoni, Ewa Ninio, Pauline Gaignard, Carole Proust, Francesca Iannacci, Sonia Karabina, Patrice Therond, François Cambien, Hervé Durand

Publikováno v: Cardiovascular Research
Cardiovascular Research, 2016, 112 (3), pp.702-713. ⟨10.1093/cvr/cvw217⟩
Cardiovascular Research, Oxford University Press (OUP), 2016, 112 (3), pp.702-713. ⟨10.1093/cvr/cvw217⟩

Aims Lipid phosphate phosphatase 3; type 2 phosphatidic acid phosphatase β (LPP3; PPAP2B ) is a transmembrane protein dephosphorylating and thereby terminating signalling of lipid substrates including lysophosphatidic acid (LPA) and sphingosine-1-ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71aaa6911e79688a15259fb729c3308
https://doi.org/10.1093/cvr/cvw217

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miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice

Autor: Jean-Sébastien Hulot, Nathalie Mougenot, Michel Clergue, Anne-Marie Lompré, Carole Proust, Veronica Codoni, David-Alexandre Trégouët, Fabrice Atassi, Jeremy Berthuin, Alexandre Marchand

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1862:611-621

We identified murine miR-322, orthologous to human miR-424, as a new regulator of insulin receptor, IGF-1 receptor and sirtuin 4 mRNA in vitro and in vivo in the heart and found that miR-322/424 is highly expressed in the heart of mice. C57Bl/6N mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482a8c754ae34daa435168ab4a25fa3b
https://doi.org/10.1016/j.bbadis.2016.01.010

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Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States

Autor: Zeyneb Kurt, Daniel Levy, David-Alexandre Trégouët, Veronica Codoni, Kei Hang K. Chan, Le Shu, Yuqi Zhao, Simin Liu, Jun Yang, Xia Yang, James G. Wilson, Guanglin Zhang, Xi Luo, Tianxiao Huan, Aldons J. Lusis

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, In press, ⟨10.1371/journal.pgen.1007040⟩
PLoS Genetics, In press, ⟨10.1371/journal.pgen.1007040⟩
PLoS Genetics, Vol 13, Iss 9, p e1007040 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ae7454989286031e439e4b0a55577b
http://europepmc.org/articles/PMC5634657

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Abstract 384: Integration of Aorta Network Models from Mouse Ath-HMDP with Human GWAS Reveals Novel Mechanisms of Coronary Artery Disease

Autor: Zeyneb Kurt, Aldons J. Lusis, Xia Yang, Veronica Codoni, Brian J. Bennett, Calvin Pan, Richard C. Davis, David-Alexandre Trégouët, Yuqi Zhao, Bin Zhang

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 36

Coronary artery disease (CAD) remains one of leading causes of death worldwide. Although the genetic heritability of CAD has been estimated to be 40 to 60%, only ~10% can be explained by the genetic loci uncovered from recent large-scale human GWAS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dce0915919a3b19ca28c6a902a2b07e7
https://doi.org/10.1161/atvb.36.suppl_1.384

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Prediction of Causal Candidate Genes in Coronary Artery Disease Loci

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 35(10)

Objective— Genome-wide association studies have to date identified 159 significant and suggestive loci for coronary artery disease (CAD). We now report comprehensive bioinformatics analyses of sequence variation in these loci to predict candidate c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb168522920bcc6de34d8ae202466ba4
https://pubmed.ncbi.nlm.nih.gov/26399919

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