Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

Autor: Veronica Codoni, Yuna Blum, Mete Civelek, Carole Proust, Oscar Franzén, Cardiogenics Consortium, IDEM Leducq Consortium CADGenomics, Johan L. M. Björkegren, Wilfried Le Goff, Francois Cambien, Aldons J. Lusis, David-Alexandre Trégouët

Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3361-3371 (2016)

Macrophages are key players involved in numerous pathophysiological pathways and an in-depth characterization of their gene regulatory networks can help in better understanding how their dysfunction may impact on human diseases. We here conducted a c

Externí odkaz: https://doaj.org/article/6400e4b80771417f88d84779bd8eaf01

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States.

Autor: Le Shu, Kei Hang K Chan, Guanglin Zhang, Tianxiao Huan, Zeyneb Kurt, Yuqi Zhao, Veronica Codoni, David-Alexandre Trégouët, Cardiogenics Consortium, Jun Yang, James G Wilson, Xi Luo, Daniel Levy, Aldons J Lusis, Simin Liu, Xia Yang

Publikováno v: PLoS Genetics, Vol 13, Iss 9, p e1007040 (2017)

Cardiovascular diseases (CVD) and type 2 diabetes (T2D) are closely interrelated complex diseases likely sharing overlapping pathogenesis driven by aberrant activities in gene networks. However, the molecular circuitries underlying the pathogenic com

Externí odkaz: https://doaj.org/article/9b65189309924c46a788c2d5b8b67fa5

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

Autor: François Cambien, Johan Björkegren, Yuna Blum, Veronica Codoni, Wilfried Le Goff, Oscar Franzén, Mete Civelek, David-Alexandre Trégouët, Carole Proust, Aldons J. Lusis

Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3361-3371 (2016)
G3
G3, 2016, 6 (10), pp.3361-3371. ⟨10.1534/g3.116.033894⟩
G3: Genes|Genomes|Genetics
G3, Genetics Society of America, 2016, 6 (10), pp.3361-3371. ⟨10.1534/g3.116.033894⟩

Cardiogenics Consortium, IDEM Leducq Consortium CADGenomics; International audience; Macrophages are key players involved in numerous pathophysiological pathways and an in-depth characterization of their gene regulatory networks can help in better un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65daad712dfeb126f227d76ab546ede8
http://g3journal.org/lookup/doi/10.1534/g3.116.033894

miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice

Autor: Jean-Sébastien Hulot, Nathalie Mougenot, Michel Clergue, Anne-Marie Lompré, Carole Proust, Veronica Codoni, David-Alexandre Trégouët, Fabrice Atassi, Jeremy Berthuin, Alexandre Marchand

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1862:611-621

We identified murine miR-322, orthologous to human miR-424, as a new regulator of insulin receptor, IGF-1 receptor and sirtuin 4 mRNA in vitro and in vivo in the heart and found that miR-322/424 is highly expressed in the heart of mice. C57Bl/6N mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482a8c754ae34daa435168ab4a25fa3b
https://doi.org/10.1016/j.bbadis.2016.01.010

Abstract 384: Integration of Aorta Network Models from Mouse Ath-HMDP with Human GWAS Reveals Novel Mechanisms of Coronary Artery Disease

Autor: Zeyneb Kurt, Aldons J. Lusis, Xia Yang, Veronica Codoni, Brian J. Bennett, Calvin Pan, Richard C. Davis, David-Alexandre Trégouët, Yuqi Zhao, Bin Zhang

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 36

Coronary artery disease (CAD) remains one of leading causes of death worldwide. Although the genetic heritability of CAD has been estimated to be 40 to 60%, only ~10% can be explained by the genetic loci uncovered from recent large-scale human GWAS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dce0915919a3b19ca28c6a902a2b07e7
https://doi.org/10.1161/atvb.36.suppl_1.384