Zobrazeno 1 - 10 of 62 pro vyhledávání: '"Veronica, Salmaso"'
1
Akademický článek
Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta
Autor: Sara Calenda, Daniela Catarzi, Flavia Varano, Erica Vigiani, Rosaria Volpini, Catia Lambertucci, Andrea Spinaci, Letizia Trevisan, Ilenia Grieco, Stephanie Federico, Giampiero Spalluto, Gianluca Novello, Veronica Salmaso, Stefano Moro, Vittoria Colotta
Publikováno v: Pharmaceuticals, Vol 17, Iss 4, p 468 (2024)
Protein kinase CK1δ (CK1δ) is a serine-threonine/kinase that modulates different physiological processes, including the cell cycle, DNA repair, and apoptosis. CK1δ overexpression, and the consequent hyperphosphorylation of specific proteins, can l
Externí odkaz: https://doaj.org/article/b944e2eddc9841ab94df3e8bb3daf1fb
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2
Akademický článek
Thermal titration molecular dynamics (TTMD): shedding light on the stability of RNA-small molecule complexes
Autor: Andrea Dodaro, Matteo Pavan, Silvia Menin, Veronica Salmaso, Mattia Sturlese, Stefano Moro
Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)
Ribonucleic acids are gradually becoming relevant players among putative drug targets, thanks to the increasing amount of structural data exploitable for the rational design of selective and potent binders that can modulate their activity. Mainly, th
Externí odkaz: https://doaj.org/article/f0921784c54d4e8c9ef991254c99200c
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3
Akademický článek
Pyrazolo-triazolo-pyrimidine Scaffold as a Molecular Passepartout for the Pan-Recognition of Human Adenosine Receptors
Autor: Veronica Salmaso, Margherita Persico, Tatiana Da Ros, Giampiero Spalluto, Sonja Kachler, Karl-Norbert Klotz, Stefano Moro, Stephanie Federico
Publikováno v: Biomolecules, Vol 13, Iss 11, p 1610 (2023)
Adenosine receptors are largely distributed in our organism and are promising therapeutic targets for the treatment of many pathologies. In this perspective, investigating the structural features of the ligands leading to affinity and/or selectivity
Externí odkaz: https://doaj.org/article/9c28abbb4ef54421a2ec2174dd725cf8
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4
Akademický článek
Thermal Titration Molecular Dynamics (TTMD): Not Your Usual Post-Docking Refinement
Autor: Silvia Menin, Matteo Pavan, Veronica Salmaso, Mattia Sturlese, Stefano Moro
Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 4, p 3596 (2023)
Molecular docking is one of the most widely used computational approaches in the field of rational drug design, thanks to its favorable balance between the rapidity of execution and the accuracy of provided results. Although very efficient in explori
Externí odkaz: https://doaj.org/article/f9e732b6397e4b7892df33be91d95995
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5
Akademický článek
Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin
Autor: Kiran S. Toti, John R. Jimah, Veronica Salmaso, Jenny E. Hinshaw, Kenneth A. Jacobson
Publikováno v: Biomolecules, Vol 12, Iss 4, p 584 (2022)
Guanine nucleotides can flip between a North and South conformation in the ribose moiety. To test the enzymatic activity of GTPases bound to nucleotides in the two conformations, we generated methanocarba guanine nucleotides in the North or South env
Externí odkaz: https://doaj.org/article/632a0ec8355d41b1802a038d1a5883b8
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6
Akademický článek
The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles
Autor: Lucia Squarcialupi, Marco Betti, Daniela Catarzi, Flavia Varano, Matteo Falsini, Annalisa Ravani, Silvia Pasquini, Fabrizio Vincenzi, Veronica Salmaso, Mattia Sturlese, Katia Varani, Stefano Moro, Vittoria Colotta
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 248-263 (2017)
New 7-amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives, substituted at the 5-position with aryl(alkyl)amino- and 4-substituted-piperazin-1-yl- moieties, were synthesized with the aim of targeting human (h) adenosine A1 and/or A2A receptor subtypes
Externí odkaz: https://doaj.org/article/3becb9391fc64475b2620dd24841af0a
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9
Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y
Autor: Zhiwei, Wen, Veronica, Salmaso, Young-Hwan, Jung, Ngan B, Phung, Varun, Gopinatth, Qasim, Shah, Alexandra T, Patterson, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, David I, Lieberman, Gregory S, Whitehead, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson
Publikováno v: J Med Chem
High affinity phenyl-piperidine P2Y(14)R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopenty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da62c41535c927994c70d1b42266cae7
https://pubmed.ncbi.nlm.nih.gov/35113556
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10
Thermal Titration Molecular Dynamics (TTMD): Not Your Usual Post-Docking Refinement
Autor: Stefano Moro, Mattia Sturlese, Matteo Pavan, VERONICA SALMASO, Silvia Menin
Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3596
Molecular docking is one of the most widely used computational approaches in the field of rational drug design, thanks to its favorable balance between the rapidity of execution and the accuracy of provided results. Although very efficient in explori
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75df111d40b1347a26aa9237e93b469
https://hdl.handle.net/11577/3469386
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