Zobrazeno 1 - 10
of 2 962
pro vyhledávání: '"Vernon W"'
Autor:
Ola E. Salama, Nikho Hizon, Melissa Del Vecchio, Kurt Kolsun, Mario A. Fonseca, David T. S. Lin, Oscar Urtatiz, Julia L. MacIsaac, Michael S. Kobor, Elizabeth A. C. Sellers, Vernon W. Dolinsky, Allison B. Dart, Meaghan J. Jones, Brandy A. Wicklow
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Objective Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases differ at a molecular level. In utero exposure to maternal type 2 diabetes (T2D) is known to be a specific ris
Externí odkaz:
https://doaj.org/article/7bffa8c1e7684ef8bb5927a17a02682a
Autor:
Sophie Grapentine, Rathnesh K. Singh, Poulami Basu, Sugashan Sivanesan, Gabriela Mattos, Oreoluwa Oresajo, Jasmine Cheema, Wendwesen Demeke, Vernon W. Dolinsky, Marica Bakovic
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Externí odkaz:
https://doaj.org/article/3e36295d6036457faab3a411a4f9da2e
Autor:
Sophie Grapentine, Rathnesh K. Singh, Poulami Basu, Sugashan Sivanesan, Gabriela Mattos, Oreoluwa Oresajo, Jasmine Cheema, Wendwesen Demeke, Vernon W. Dolinsky, Marica Bakovic
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The mechanisms of NASH development in the context of age and genetics are not fully elucidated. This study investigates the age-dependent liver defects during NASH development in mice with heterozygous deletion of Pcyt2 (Pcyt2 +/− ), the r
Externí odkaz:
https://doaj.org/article/7fbdcffd68bb48f68c63e46d0d6a0593
Autor:
Matthew D. Martens, Nivedita Seshadri, Lucas Nguyen, Donald Chapman, Elizabeth S. Henson, Bo Xiang, Landon Falk, Arielys Mendoza, Sunil Rattan, Jared T. Field, Philip Kawalec, Spencer B. Gibson, Richard Keijzer, Ayesha Saleem, Grant M. Hatch, Christine A. Doucette, Jason M. Karch, Vernon W. Dolinsky, Ian M. Dixon, Adrian R. West, Christof Rampitsch, Joseph W. Gordon
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-16 (2021)
Abstract Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent role in the evolution of necrotic cell death, disrupting ER calcium homeostasis and i
Externí odkaz:
https://doaj.org/article/e1343dcb2c5b484c91d04a2bde3e5a8e
Autor:
Prasoon Agarwal, Brandy A. Wicklow, Allison B. Dart, Nikho A. Hizon, Elizabeth A.C. Sellers, Jonathan M. McGavock, Charlotte P. J. Talbot, Mario A. Fonseca, Wayne Xu, James R. Davie, Meaghan J. Jones, Animesh Acharjee, Vernon W. Dolinsky
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
ObjectiveRates of type 2 diabetes (T2D) among adolescents are on the rise. Epigenetic changes could be associated with the metabolic alterations in adolescents with T2D.MethodsWe performed a cross sectional integrated analysis of DNA methylation data
Externí odkaz:
https://doaj.org/article/ed82741761704a319291c6943fd6eae0
Autor:
Laura K. Cole, Genevieve C. Sparagna, Marilyne Vandel, Bo Xiang, Vernon W. Dolinsky, Grant M. Hatch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Berberine (BBR) is an isoquinoline alkaloid from plants known to improve cardiac mitochondrial function in gestational diabetes mellitus (GDM) offspring but the mechanism is poorly understood. We examined the role of the mitochondrial phosph
Externí odkaz:
https://doaj.org/article/b4c4b65b3b994db5bc6e62dfd3f8fc69
Publikováno v:
Human Resources for Health, Vol 18, Iss 1, Pp 1-9 (2020)
Abstract Background Physicians play a critical role in healthcare delivery. With an aging US population, population growth, and a greater insured population following the Affordable Care Act (ACA), healthcare demand is growing at an unprecedented pac
Externí odkaz:
https://doaj.org/article/61193a1000ea49c2a3ffa47646811e7c
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263520 (2022)
Pulmonary vascular remodeling (PVR) in utero results in the development of heart failure. The alterations that occur in cardiac lipid and mitochondrial bioenergetics during the development of in utero PVR was unknown. In this study, PVR was induced i
Externí odkaz:
https://doaj.org/article/86edeae99fac4b96a0acbf1a2988c998
Publikováno v:
Life, Vol 13, Iss 2, p 301 (2023)
Pregnancy involves a range of metabolic adaptations to supply adequate energy for fetal growth and development. Gestational diabetes (GDM) is defined as hyperglycemia with first onset during pregnancy. GDM is a recognized risk factor for both pregnan
Externí odkaz:
https://doaj.org/article/356be4e4882646d1a602afc0fde91b9d
Autor:
Christopher J. Oldfield, Teri L. Moffatt, Kimberley A. O'Hara, Bo Xiang, Vernon W. Dolinsky, Todd A. Duhamel
Publikováno v:
Physiological Reports, Vol 9, Iss 16, Pp n/a-n/a (2021)
Abstract Obesity, type 2 diabetes, and heart disease are linked to an unhealthy diet. Sarco(endo)plasmic reticulum calcium (Ca2+) ATPase 2a (SERCA2a) controls cardiac function by transporting Ca2+ in cardiomyocytes. SERCA2a is altered by diet and ace
Externí odkaz:
https://doaj.org/article/880616f7b546467d8cd271f29449ae6b